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Bio-Design and Manufacturing  2023 Vol.6 No.6 P.661-675

http://doi.org/10.1007/s42242-023-00247-1


The prospects for bioprinting tumor models: recent advances in their applications


Author(s):  Changru Zhang, Xiaoqin Qiu, Yu Dai, Weiqing Kong, Yihao Liu, Haoyi Niu, Chengwei Wang, Xuelian Mi, Hui Wang, Ya Ren, Han Yang, Kerong Dai & Jinwu Wang

Affiliation(s):  School of Rehabilitation Medicine, Weifang Medical University, Weifang 261041, China; more

Corresponding email(s):   yanghan0609@sjtu.edu.cn, krdai@163.com, wangjw-team@shsmu.edu.cn

Key Words:  Bioprinting, Tissue engineering, Tumor organoid


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Changru Zhang, Xiaoqin Qiu, Yu Dai, Weiqing Kong, Yihao Liu, Haoyi Niu, Chengwei Wang, Xuelian Mi, Hui Wang, Ya Ren, Han Yang, Kerong Dai & Jinwu Wang. The prospects for bioprinting tumor models: recent advances in their applications[J]. Journal of Zhejiang University Science D, 2023, 6(6): 661-675.

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author="Changru Zhang, Xiaoqin Qiu, Yu Dai, Weiqing Kong, Yihao Liu, Haoyi Niu, Chengwei Wang, Xuelian Mi, Hui Wang, Ya Ren, Han Yang, Kerong Dai & Jinwu Wang",
journal="Journal of Zhejiang University Science D",
volume="6",
number="6",
pages="661-675",
year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-023-00247-1"
}

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Abstract: 
Three-dimensional (3D) tumor models prepared from patient-derived cells have been reported to imitate some of the biological development processes of in situ tumors in vitro. These 3D tumor models share several important characteristics with their in vivo tumor counterparts. Accordingly, their applications in tumor modeling, drug screening, and precision-targeted treatment are promising. However, the establishment of tumor models is subject to several challenges, including advancements in scale size, repeatability, structural precision in time and space, vascularization, and the tumor microenvironment. Recently, bioprinting technologies enabling the editorial arrangement of cells, factors, and materials have improved the simulation of tumor models in vitro. Among the 3D bioprinted tumor models, the organoid model has been widely appreciated for its advantages of maintaining high heterogeneity and capacity for simulating the developmental process of tumor tissues. In this review, we outline approaches and potential prospects for tumor model bioprinting and discuss the existing bioprinting technologies and bioinks in tumor model construction. The multidisciplinary combination of tumor pathology, molecular biology, material science, and additive manufacturing will help overcome the barriers to tumor model construction by allowing consideration of the structural and functional characteristics of in vitro models and promoting the development of heterogeneous tumor precision therapies.

上海交通大学医学院附属九院王金武教授等 | 生物打印肿瘤模型的最新应用进展与前景

本综述论文聚焦生物打印肿瘤模型的最新应用进展与前景。从患者来源的肿瘤细胞制备的三维(3D)肿瘤模型已被报道能够在体外模拟原位肿瘤的一些生物发展过程。这些3D肿瘤模型与体内肿瘤具有几个重要的共同特征。因此,它们在肿瘤建模、肿瘤药物筛选和精准靶向肿瘤治疗方面具有很大的应用前景。然而,肿瘤模型的建立面临着一些挑战,包括尺度大小的提升、可重复性、时间和空间上的精确结构、血管化和肿瘤微环境。最近,生物打印技术使得细胞、因子和材料的编辑性排列得以改善,进而提升肿瘤模型在体外的模拟效果。在3D生物打印的肿瘤模型中,类器官模型因其保持高度异质性和模拟肿瘤组织发展过程的优势而受到广泛关注。在本综述中,我们概述了肿瘤模型生物打印的方法和潜在前景,并讨论了肿瘤模型构建中现有的生物打印技术和生物墨水。肿瘤病理学、分子生物学、材料科学和增材制造的多学科结合将有助于克服肿瘤模型构建的障碍,通过考虑体外模型的结构和功能特点,推动异质性肿瘤精准治疗的发展。

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