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On-line Access: 2022-07-01

Received: 2021-09-22

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Crosschecked: 2022-02-04

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Bio-Design and Manufacturing  2022 Vol.5 No.3 P.617-626

http://doi.org/10.1007/s42242-022-00183-6


Cell sedimentation during 3D bioprinting: a mini review


Author(s):  Heqi Xu, Jiachen Liu, Zhengyi Zhang & Changxue Xu

Affiliation(s):  Department of Industrial, Manufacturing, and Systems Engineering, Texas Tech University, Lubbock, TX 79409, USA; more

Corresponding email(s):   zhengyizhang@hust.edu.cn, changxue.xu@ttu.edu

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Heqi Xu, Jiachen Liu, Zhengyi Zhang & Changxue Xu. Cell sedimentation during 3D bioprinting: a mini review[J]. Journal of Zhejiang University Science D, 2022, 5(3): 617-626.

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Abstract: 

德克萨斯理工大学徐长学等 | 关于3D生物打印中细胞沉降问题的观点

本观点论文聚焦3D生物打印中的细胞沉降问题。3D生物打印通过对于生物墨水的逐层精确定位来制造3D人造组织/器官。尽管近些年3D生物打印已经被越来越多地用于组织工程和再生医学,3D生物打印仍然面临许多挑战,例如打印过程中的细胞沉降问题。生物墨水,作为3D生物打印中的重要元素,通常由生物材料和活性细胞组成。当细胞所受到的重力大于细胞所受到的浮力时,细胞将在重力的驱使下沉降并堆积在生物墨水容器的底部,这将会加剧细胞的凝聚并影响打印精度和可靠性。本文总结了前人提出的细胞沉降的问题,讨论了细胞沉降的机理,表征了细胞沉降的行为,并总结了潜在的有效缓解细胞沉降的方法。

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