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On-line Access: 2022-12-03
Received: 2022-03-16
Revision Accepted: 2022-10-07
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Three-dimensional kagome structures in a PCL/HA-based hydrogel scaffold to lead slow BMP-2 release for effective bone regeneration
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Se-Hwan Lee, Kang-Gon Lee, Jaeyeon Lee, Yong Sang Cho, Min-Soo Ghim, Soojin Kim, Su-Jin Heo, Yongdoo Park, Young-Sam Cho & Bu-Kyu Lee . Three-dimensional kagome structures in a PCL/HA-based hydrogel scaffold to lead slow BMP-2 release for effective bone regeneration[J]. Journal of Zhejiang University Science D, 2023, 6(1): 12-25.
@article{title="Three-dimensional kagome structures in a PCL/HA-based hydrogel scaffold to lead slow BMP-2 release for effective bone regeneration",
author="Se-Hwan Lee, Kang-Gon Lee, Jaeyeon Lee, Yong Sang Cho, Min-Soo Ghim, Soojin Kim, Su-Jin Heo, Yongdoo Park, Young-Sam Cho & Bu-Kyu Lee ",
journal="Journal of Zhejiang University Science D",
volume="6",
number="1",
pages="12-25",
year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-022-00219-x"
}
%0 Journal Article
%T Three-dimensional kagome structures in a PCL/HA-based hydrogel scaffold to lead slow BMP-2 release for effective bone regeneration
%A Se-Hwan Lee
%A Kang-Gon Lee
%A Jaeyeon Lee
%A Yong Sang Cho
%A Min-Soo Ghim
%A Soojin Kim
%A Su-Jin Heo
%A Yongdoo Park
%A Young-Sam Cho & Bu-Kyu Lee
%J Journal of Zhejiang University SCIENCE D
%V 6
%N 1
%P 12-25
%@ 1869-1951
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-022-00219-x
TY - JOUR
T1 - Three-dimensional kagome structures in a PCL/HA-based hydrogel scaffold to lead slow BMP-2 release for effective bone regeneration
A1 - Se-Hwan Lee
A1 - Kang-Gon Lee
A1 - Jaeyeon Lee
A1 - Yong Sang Cho
A1 - Min-Soo Ghim
A1 - Soojin Kim
A1 - Su-Jin Heo
A1 - Yongdoo Park
A1 - Young-Sam Cho & Bu-Kyu Lee
J0 - Journal of Zhejiang University Science D
VL - 6
IS - 1
SP - 12
EP - 25
%@ 1869-1951
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-022-00219-x
Abstract: Osteoconductive function is remarkably low in bone disease in the absence of bone tissue surrounding the grafting site, or if
the bone tissue is in poor condition. Thus, an effective bone graft in terms of both osteoconductivity and osteoinductivity is
required for clinical therapy. Recently, the three-dimensional (3D) kagome structure has been shown to be advantageous for
bone tissue regeneration due to its mechanical properties. In this study, a polycaprolactone (PCL) kagome-structure scaffold
containing a hyaluronic acid (HA)-based hydrogel was fabricated using a 3D printing technique. The retention capacity of
the hydrogel in the scaffold was assessed in vivo with a rat calvaria subcutaneous model for 3 weeks, and the results were
compared with those obtained with conventional 3D-printed PCL grid-structure scaffolds containing HA-based hydrogel
and bulk-type HA-based hydrogel. The retained hydrogel in the kagome-structure scaffold was further evaluated by in vivo
imaging system analysis. To further reinforce the osteoinductivity of the kagome-structure scaffold, a PCL kagome-structure
scaffold with bone morphogenetic protein-2 (BMP-2) containing HA hydrogel was fabricated and implanted in a calvarial
defect model of rabbits for 16 weeks. The bone regeneration characteristics were evaluated with hematoxylin and eosin
(H&E), Masson’s trichrome staining, and micro-CT image analysis.
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