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On-line Access: 2024-08-27

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Bio-Design and Manufacturing  2024 Vol.7 No.4 P.591-595

http://doi.org/10.1007/s42242-024-00283-5


Implantable probe with integrated reference electrode for in situ neural signal and calcium ion monitoring


Author(s):  Junyu Xiao, Mengfei Xu, Longchun Wang, Bin Yang & Jingquan Liu

Affiliation(s):  National Key Laboratory of Advanced Micro and Nano Manufacture Technology, Shanghai Jiao Tong University, Shanghai 200240, China; more

Corresponding email(s):   jqliu@sjtu.edu.cn

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Junyu Xiao, Mengfei Xu, Longchun Wang, Bin Yang & Jingquan Liu. Implantable probe with integrated reference electrode for in situ neural signal and calcium ion monitoring[J]. Journal of Zhejiang University Science D, 2024, 7(4): 591-595.

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Abstract: 

上海交通大学刘景全团队 | 集成电生理记录和离子浓度监测功能的植入式神经探针

本文聚焦集成电生理记录和离子浓度监测功能的植入式神经探针。监测神经元的电生理活动和血液中的钙离子可以帮助人们更好地了解与疾病相关的神经系统回路。然而,当前原位钙离子监测工具很少,且大多集成度低、灵敏度有限。本文提出一种集成原位Ag/AgCl 参比电极(ISA/ARE)的植入式探针,该探针可以监测动作电位(AP)和Ca2+浓度。实验结果表明,Ca2+传感器的灵敏度可达100.7 mV/decade,其在干扰物实验中呈现良好的选择性。本研究通过铂黑修饰的12个电生理电极记录到了神经元的AP,而当将CaCl2溶液重复微注射到大脑的CA1区域时,Ca2+传感器则观察到神经元的可逆电位变化。上述结果表明,该探针能够满足电生理信号和离子浓度同步监测的需求,加深人们对神经回路的理解,促进脑科学的发展。

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