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On-line Access: 2024-01-26
Received: 2023-02-20
Revision Accepted: 2023-11-07
Crosschecked: 2023-12-19
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Semi-implantable device based on multiplexed microfilament electrode cluster for continuous monitoring of physiological ions
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Shuang Huang, Shantao Zheng, Mengyi He, Chuanjie Yao, Xinshuo Huang, Zhengjie Liu, Qiangqiang Ouyang, Jing Liu, Feifei Wu, Hang Gao, Xi Xie & Hui-jiuan Chen. Semi-implantable device based on multiplexed microfilament electrode cluster for continuous monitoring of physiological ions[J]. Journal of Zhejiang University Science D, 2024, 7(1): 88-103.
@article{title="Semi-implantable device based on multiplexed microfilament
electrode cluster for continuous monitoring of physiological ions",
author="Shuang Huang, Shantao Zheng, Mengyi He, Chuanjie Yao, Xinshuo Huang, Zhengjie Liu, Qiangqiang Ouyang, Jing Liu, Feifei Wu, Hang Gao, Xi Xie & Hui-jiuan Chen",
journal="Journal of Zhejiang University Science D",
volume="7",
number="1",
pages="88-103",
year="2024",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-023-00262-2"
}
%0 Journal Article
%T Semi-implantable device based on multiplexed microfilament
electrode cluster for continuous monitoring of physiological ions
%A Shuang Huang
%A Shantao Zheng
%A Mengyi He
%A Chuanjie Yao
%A Xinshuo Huang
%A Zhengjie Liu
%A Qiangqiang Ouyang
%A Jing Liu
%A Feifei Wu
%A Hang Gao
%A Xi Xie & Hui-jiuan Chen
%J Journal of Zhejiang University SCIENCE D
%V 7
%N 1
%P 88-103
%@ 1869-1951
%D 2024
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-023-00262-2
TY - JOUR
T1 - Semi-implantable device based on multiplexed microfilament
electrode cluster for continuous monitoring of physiological ions
A1 - Shuang Huang
A1 - Shantao Zheng
A1 - Mengyi He
A1 - Chuanjie Yao
A1 - Xinshuo Huang
A1 - Zhengjie Liu
A1 - Qiangqiang Ouyang
A1 - Jing Liu
A1 - Feifei Wu
A1 - Hang Gao
A1 - Xi Xie & Hui-jiuan Chen
J0 - Journal of Zhejiang University Science D
VL - 7
IS - 1
SP - 88
EP - 103
%@ 1869-1951
Y1 - 2024
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-023-00262-2
Abstract: Modern medicine is increasingly interested in advanced sensors to detect and analyze biochemical indicators. Ion sensors
based on potentiometric methods are a promising platform for monitoring physiological ions in biological subjects. Current
semi-implantable devices are mainly based on single-parameter detection. Miniaturized semi-implantable electrodes for
multiparameter sensing have more restrictions on the electrode size due to biocompatibility considerations, but reducing the
electrode surface area could potentially limit electrode sensitivity. This study developed a semi-implantable device system
comprising a multiplexed microfilament electrode cluster (MMEC) and a printed circuit board for real-time monitoring of
intra-tissue K+, Ca2+, and Na+ concentrations. The electrode surface area was less important for the potentiometric sensing
mechanism, suggesting the feasibility of using a tiny fiber-like electrode for potentiometric sensing. The MMEC device
exhibited a broad linear response (K+: 232 mmol/L; Ca2+: 0.54 mmol/L; Na+: 10160 mmol/L), high sensitivity (about
2045 mV/decade), temporal stability (>2 weeks), and good selectivity (>80%) for the above ions. In vitro detection and in vivo
subcutaneous and brain experiment results showed that the MMEC system exhibits good multi-ion monitoring performance
in several complex environments. This work provides a platform for the continuous real-time monitoring of ion fluctuations
in different situations and has implications for developing smart sensors to monitor human health.
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