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Bio-Design and Manufacturing  2024 Vol.7 No.1 P.88-103

http://doi.org/10.1007/s42242-023-00262-2


Semi-implantable device based on multiplexed microfilament electrode cluster for continuous monitoring of physiological ions


Author(s):  Shuang Huang, Shantao Zheng, Mengyi He, Chuanjie Yao, Xinshuo Huang, Zhengjie Liu, Qiangqiang Ouyang, Jing Liu, Feifei Wu, Hang Gao, Xi Xie & Hui-jiuan Chen

Affiliation(s):  State Key Laboratory of Optoelectronic Materials and Technologies, Guangdong Province Key Laboratory of Display Material and Technology, School of Electronics and Information Technology, Sun Yat-Sen University, Guangzhou 510006, China; more

Corresponding email(s):   xiexi27@mail.sysu.edu.cn, chenhuix5@mail.sysu.edu.cn

Key Words:  Multiplexed microfilament electrode cluster, Physiological ion sensing, · Subcutaneous and brain experiment, Wearable platform for multi-ion detection, Continuous real-time monitoring system


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Shuang Huang, Shantao Zheng, Mengyi He, Chuanjie Yao, Xinshuo Huang, Zhengjie Liu, Qiangqiang Ouyang, Jing Liu, Feifei Wu, Hang Gao, Xi Xie & Hui-jiuan Chen. Semi-implantable device based on multiplexed microfilament electrode cluster for continuous monitoring of physiological ions[J]. Journal of Zhejiang University Science D, 2024, 7(1): 88-103.

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author="Shuang Huang, Shantao Zheng, Mengyi He, Chuanjie Yao, Xinshuo Huang, Zhengjie Liu, Qiangqiang Ouyang, Jing Liu, Feifei Wu, Hang Gao, Xi Xie & Hui-jiuan Chen",
journal="Journal of Zhejiang University Science D",
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%A Shuang Huang
%A Shantao Zheng
%A Mengyi He
%A Chuanjie Yao
%A Xinshuo Huang
%A Zhengjie Liu
%A Qiangqiang Ouyang
%A Jing Liu
%A Feifei Wu
%A Hang Gao
%A Xi Xie & Hui-jiuan Chen
%J Journal of Zhejiang University SCIENCE D
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%I Zhejiang University Press & Springer
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A1 - Shuang Huang
A1 - Shantao Zheng
A1 - Mengyi He
A1 - Chuanjie Yao
A1 - Xinshuo Huang
A1 - Zhengjie Liu
A1 - Qiangqiang Ouyang
A1 - Jing Liu
A1 - Feifei Wu
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Abstract: 
Modern medicine is increasingly interested in advanced sensors to detect and analyze biochemical indicators. Ion sensors based on potentiometric methods are a promising platform for monitoring physiological ions in biological subjects. Current semi-implantable devices are mainly based on single-parameter detection. Miniaturized semi-implantable electrodes for multiparameter sensing have more restrictions on the electrode size due to biocompatibility considerations, but reducing the electrode surface area could potentially limit electrode sensitivity. This study developed a semi-implantable device system comprising a multiplexed microfilament electrode cluster (MMEC) and a printed circuit board for real-time monitoring of intra-tissue K+, Ca2+, and Na+ concentrations. The electrode surface area was less important for the potentiometric sensing mechanism, suggesting the feasibility of using a tiny fiber-like electrode for potentiometric sensing. The MMEC device exhibited a broad linear response (K+: 2–32 mmol/L; Ca2+: 0.5–4 mmol/L; Na+: 10–160 mmol/L), high sensitivity (about 20–45 mV/decade), temporal stability (>2 weeks), and good selectivity (>80%) for the above ions. In vitro detection and in vivo subcutaneous and brain experiment results showed that the MMEC system exhibits good multi-ion monitoring performance in several complex environments. This work provides a platform for the continuous real-time monitoring of ion fluctuations in different situations and has implications for developing smart sensors to monitor human health.

中山大学电子与信息工程学院陈惠琄谢曦等 | 半植入式多功能微丝电极簇连续监测生理离子

本论文聚焦于具有多种生理离子检测功能的传感器制备和应用研究。现代医学越来越依赖具有检测和分析生化物指标功能的先进传感器。基于电位计检测法的半植入式离子传感器是监测生物体内生理离子的一个有效平台。考虑到器件的生物相容性,用于多参数传感的微型半植入式电极对电极尺寸有更多限制。本研究报道了一种半植入式传感系统,由多功能微丝电极簇(MMEC)和印刷电路板组成,用于实时监测组织内的 K+、Ca2+ 和 Na+ 浓度。其中,体外研究证明了电极表面积对电位传感机制的影响较小,这表明使用微小的纤维状电极进行电位传感是可行的。此外,本研究验证了MMEC 装置具有广泛的线性响应(K+:2-32 mmol/L;Ca2+:0.5-4 mmol/L;Na+:10-160 mmol/L)、较高的灵敏度(约 20-45 mV/decade)、较好的长期稳定性(>2 周)以及良好的特异性选择性(>80%)等特性。最终,大鼠皮下实验及脑部实验结果表明,MMEC 系统在体内不同应用场景中仍能表现出良好的多离子监测性能。这项工作为持续实时监测体内不同环境中的离子波动提供了一个平台,对开发监测人体健康的智能传感器具有重要意义。

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