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Bio-Design and Manufacturing  2024 Vol.7 No.4 P.548-565

http://doi.org/10.1007/s42242-024-00301-6


Electrochemical biosensors for point-of-care testing


Author(s):  Jinsol Kim, Juho Jeong & Seung Hwan Ko

Affiliation(s):  Department of Mechanical Engineering, Seoul National University, Seoul 08826, Republic of Korea; more

Corresponding email(s):   maxko@snu.ac.kr

Key Words:  Point-of-care testing (POCT) · Electrochemical sensor · Enzyme · Antibody · Health care


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Jinsol Kim, Juho Jeong & Seung Hwan Ko. Electrochemical biosensors for point-of-care testing[J]. Journal of Zhejiang University Science D, 2024, 7(4): 548-565.

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Abstract: 
Point-of-care testing (POCT) is the practice of diagnosing and monitoring diseases where the patient is located, as opposed to traditional treatment conducted solely in a medical laboratory or other clinical setting. POCT has been less common in the recent past due to a lack of portable medical devices capable of facilitating effective medical testing. However, recent growth has occurred in this field due to advances in diagnostic technologies, device miniaturization, and progress in wearable electronics. Among these developments, electrochemical sensors have attracted interest in the POCT field due to their high sensitivity, compact size, and affordability. They are used in various applications, from disease diagnosis to health status monitoring. In this paper we explore recent advancements in electrochemical sensors, the methods of fabricating them, and the various types of sensing mechanisms that can be used. Furthermore, we delve into methods for immobilizing specific biorecognition elements, including enzymes, antibodies, and aptamers, onto electrode surfaces and how these sensors are used in real-world POCT settings.

首尔大学Seung Hwan Ko等 | 用于即时检验的电化学生物传感器

本综述论文聚焦用于即时检验的电化学生物传感器。即时检验(POCT)是一种在患者身边进行疾病诊断和监测的做法,与仅在医学实验室或其他临床环境中进行的传统治疗不同。由于缺乏能够促进有效医疗测试的便携式医疗设备,POCT在最近过去较少见。然而这一领域近期呈现出增长态势,得益于诊断技术的进步、设备的小型化,以及可穿戴电子设备的快速发展。在这些发展中,电化学传感器因其高灵敏度、紧凑的尺寸并且经济实惠而在POCT领域引起了兴趣。它们被用于从疾病诊断到健康状况监测的各种应用。在本文中,我们探讨了电化学传感器的最新进展、制造它们的方法以及可以使用的各种传感机制。此外,我们还探究了如何将酶、抗体和核酸适配体等特定生物识别元素固定于电极表面,以及这些传感器在现实世界即时检验中的应用方式。

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