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Journal of Zhejiang University SCIENCE B 2021 Vol.22 No.3 P.171-189


Applications of smartphone-based near-infrared (NIR) imaging, measurement, and spectroscopy technologies to point-of-care (POC) diagnostics

Author(s):  Wenjing HUANG, Shenglin LUO, Dong YANG, Sheng ZHANG

Affiliation(s):  Ningbo Research Institute, Zhejiang University, Ningbo 315100, China; more

Corresponding email(s):   szhang1984@nit.zju.edu.cn

Key Words:  Point-of-care (POC) diagnostics, Near-infrared (NIR) fluorescent imaging, Aggregation-induced emission (AIE), Smartphone-based imaging, Fluorescent probe

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Wenjing HUANG, Shenglin LUO, Dong YANG, Sheng ZHANG. Applications of smartphone-based near-infrared (NIR) imaging, measurement, and spectroscopy technologies to point-of-care (POC) diagnostics[J]. Journal of Zhejiang University Science B, 2021, 22(3): 171-189.

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author="Wenjing HUANG, Shenglin LUO, Dong YANG, Sheng ZHANG",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Applications of smartphone-based near-infrared (NIR) imaging, measurement, and spectroscopy technologies to point-of-care (POC) diagnostics
%A Wenjing HUANG
%A Shenglin LUO
%A Dong YANG
%A Sheng ZHANG
%J Journal of Zhejiang University SCIENCE B
%V 22
%N 3
%P 171-189
%@ 1673-1581
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2000388

T1 - Applications of smartphone-based near-infrared (NIR) imaging, measurement, and spectroscopy technologies to point-of-care (POC) diagnostics
A1 - Wenjing HUANG
A1 - Shenglin LUO
A1 - Dong YANG
A1 - Sheng ZHANG
J0 - Journal of Zhejiang University Science B
VL - 22
IS - 3
SP - 171
EP - 189
%@ 1673-1581
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2000388

The role of point-of-care (POC) diagnostics is important in public health. With the support of smartphones, POC diagnostic technologies can be greatly improved. This opportunity has arisen from not only the large number and fast spread of cell-phones across the world but also their improved imaging/diagnostic functions. As a tool, the smartphone is regarded as part of a compact, portable, and low-cost system for real-time POC, even in areas with few resources. By combining near-infrared (NIR) imaging, measurement, and spectroscopy techniques, pathogens can be detected with high sensitivity. The whole process is rapid, accurate, and low-cost, and will set the future trend for POC diagnostics. In this review, the development of smartphone-based NIR fluorescent imaging technology was described, and the quality and potential of POC applications were discussed.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


[1]AchiguiHF, SawanM, FayomiCJB, 2008. A monolithic based NIRS front-end wireless sensor. Microelectronics J, 39(10):1209-1217.

[2]AntarisAL, ChenH, ChengK, et al., 2016. A small-molecule dye for NIR-II imaging. Nat Mater, 15(2):235-242.

[3]Arafat HossainM, CanningJ, AstS, et al., 2015. Combined “dual” absorption and fluorescence smartphone spectrometers. Opt Lett, 40(8):1737-1740.

[4]BaldurssonS, KaranisP, 2011. Waterborne transmission of protozoan parasites: review of worldwide outbreaks—an update 2004‒2010. Water Res, 45(20):6603-6614.

[5]BerlecA, ŠtrukeljB, 2014. A high-throughput biliverdin assay using infrared fluorescence. J Vet Diagn Invest, 26(4):521-526.

[6]BerlecA, ZavršnikJ, ButinarM, et al., 2015. In vivo imaging of Lactococcus lactis, Lactobacillus plantarum and Escherichia coli expressing infrared fluorescent protein in mice. Microb Cell Fact, 14:181.

[7]BreslauerDN, MaamariRN, SwitzNA, et al., 2009. Mobile phone based clinical microscopy for global health applications. PLoS ONE, 4(7):e6320.

[8]BuiN, NguyenA, NguyenP, et al., 2017. PhO2: smartphone based blood oxygen level measurement systems using near-IR and RED wave-guided light. Proceedings of the 15th ACM Conference on Embedded Network Sensor Systems CD-ROM. ACM, New York, USA, p.230-244.

[9]Ceylan KoydemirH, OzcanA, 2018. Smartphones democratize advanced biomedical instruments and foster innovation. Clin Pharmacol Ther, 104(1):38-41.

[10]ChanceB, NiokaS, KentJ, et al., 1988. Time-resolved spectroscopy of hemoglobin and myoglobin in resting and ischemic muscle. Anal Biochem, 174(2):698-707.

[11]ChenCY, HofherrSE, SchwegelJS, et al., 2008. Real-time near infrared fluorescence imaging of viruses and ligands. Mol Ther, 16(S1):S21.

[12]ChenZY, ZhuN, PachecoS, et al., 2014. Single camera imaging system for color and near-infrared fluorescence image guided surgery. Biomed Opt Express, 5(8):2791-2797.

[13]ChouCC, LeeTT, ChenCH, et al., 2006. Design of microarray probes for virus identification and detection of emerging viruses at the genus level. BMC Bioinformatics, 7:232.

[14]ChungS, BreshearsLE, YoonJY, 2018. Smartphone near infrared monitoring of plant stress. Comput Electron Agric, 154:93-98.

[15]CunninghamBP, BolleyB, 2016. Telemedicine and smartphones: is there a role for technology in the austere environment? In: de Dios Robinson J (Ed.), Orthopaedic Trauma in the Austere Environment: A Practical Guide to Care in the Humanitarian Setting. Springer, Cham, p.677-683.

[16]DiasDDS, 2015. Design of a Low-Cost Wireless NIRS System with Embedded Linux and a Smartphone Interface. MS Thesis, Wright State University, Ohio, USA.

[17]DingD, LiK, LiuB, et al., 2013. Bioprobes based on AIE fluorogens. Acc Chem Res, 46(11):2441-2453.

[18]DinjaskiN, SuriS, ValleJ, et al., 2014. Near-infrared fluorescence imaging as an alternative to bioluminescent bacteria to monitor biomaterial-associated infections. Acta Biomater, 10(7):2935-2944.

[19]FosterAE, KwonS, KeS, et al., 2008. In vivo fluorescent optical imaging of cytotoxic T lymphocyte migration using IRDye800CW near-infrared dye. Appl Opt, 47(31):5944-5952.

[20]FrangioniJV, 2003. In vivo near-infrared fluorescence imaging. Curr Opin Chem Biol, 7(5):626-634.

[21]FuMY, XiaoY, QianXH, et al., 2008. A design concept of long-wavelength fluorescent analogs of rhodamine dyes: replacement of oxygen with silicon atom. Chem Commun, (15):1780-1782.

[22]GhassemiP, WangBH, WangJT, et al., 2017. Evaluation of mobile phone performance for near-infrared fluorescence imaging. IEEE Trans Biomed Eng, 64(7):1650-1653.

[23]GopinathSCB, TangTH, ChenY, et al., 2014. Bacterial detection: from microscope to smartphone. Biosens Bioelectron, 60:332-342.

[24]HandaT, KatareRG, SasaguriS, et al., 2009. Preliminary experience for the evaluation of the intraoperative graft patency with real color charge-coupled device camera system: an advanced device for simultaneous capturing of color and near-infrared images during coronary artery bypass graft. Interact Cardiovasc Thorac Surg, 9(2):150-154.

[25]HaspotF, LavaultA, SinzgerC, et al., 2012. Human cytomegalovirus entry into dendritic cells occurs via a macropinocytosis-like pathway in a pH-independent and cholesterol-dependent manner. PLoS ONE, 7(4):e34795.

[26]HeukerM, GomesA, van DijlJM, et al., 2016. Preclinical studies and prospective clinical applications for bacteria-targeted imaging: the future is bright. Clin Transl Imaging, 4(4):253-264.

[27]HolFJH, DekkerC, 2014. Zooming in to see the bigger picture: microfluidic and nanofabrication tools to study bacteria. Science, 346(6208):1251821.

[28]HolzC, OfekE, 2018. Doubling the signal quality of smartphone camera pulse oximetry using the display screen as a controllable selective light source. Proceedings of the 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, p.1-4.

[29]HongGS, AntarisAL, DaiHJ, 2017. Near-infrared fluorophores for biomedical imaging. Nat Biomed Eng, 1:0010.

[30]HuangES, JohnsonRA, 2000. Human cytomegalovirus—no longer just a DNA virus. Nat Med, 6(8):863.

[31]HussainI, BoraAJ, SarmaD, et al., 2018. Design of a smartphone platform compact optical system operational both in visible and near infrared spectral regime. IEEE Sens J, 18(12):4933-4939.

[32]HyunH, WadaH, BaoK, et al., 2014. Phosphonated near-infrared fluorophores for biomedical imaging of bone. Angew Chem Int Ed, 53(40):10668-10672.

[33]HyunH, OwensEA, WadaH, et al., 2015. Cartilage-specific near-infrared fluorophores for biomedical imaging. Angew Chem Int Ed, 54(30):8648-8652.

[34]IsomuraM, YamadaK, NoguchiK, et al., 2017. Near-infrared fluorescent protein iRFP720 is optimal for in vivo fluorescence imaging of rabies virus infection. J Gen Virol, 98(11):2689-2698.

[35]KaileK, GodavartyA, 2019. Development and validation of a smartphone-based near-infrared optical imaging device to measure physiological changes in-vivo. Micromachines, 10(3):180.

[36]KanvaAK, SharmaCJ, DebS, 2014. Determination of SpO2 and heart-rate using smartphone camera. Proceedings of International Conference on Control, Instrumentation, Energy and Communication, p.237-241.

[37]KimCK, LeeS, KohD, et al., 2011. Development of wireless NIRS system with dynamic removal of motion artifacts. Biomed Eng Lett, 1(4):254-259.

[38]KimJG, LiuH, 2007. Variation of haemoglobin extinction coefficients can cause errors in the determination of haemoglobin concentration measured by near-infrared spectroscopy. Phys Med Biol, 52(20):6295-6322.

[39]KleerebezemM, BeerthuyzenMM, VaughanEE, et al., 1997. Controlled gene expression systems for lactic acid bacteria: transferable nisin-inducible expression cassettes for Lactococcus, Leuconostoc, and Lactobacillus spp. Appl Environ Microbiol, 63(11):4581-4584.

[40]KnowltonS, JoshiA, SyrristP, et al., 2017. 3D-printed smartphone-based point of care tool for fluorescence- and magnetophoresis-based cytometry. Lab Chip, 17(16):2839-2851.

[41]KoideY, UranoY, HanaokaK, et al., 2011. Evolution of group 14 rhodamines as platforms for near-infrared fluorescence probes utilizing photoinduced electron transfer. ACS Chem Biol, 6(6):600-608.

[42]KoydemirHC, GorocsZ, TsengD, et al., 2015. Rapid imaging, detection and quantification of Giardia lamblia cysts using mobile-phone based fluorescent microscopy and machine learning. Lab Chip, 15(5):1284-1293.

[43]KühnemundM, WeiQS, DaraiE, et al., 2017. Targeted DNA sequencing and in situ mutation analysis using mobile phone microscopy. Nat Commun, 8:13913.

[44]LiangPS, ParkTS, YoonJY, 2014. Rapid and reagentless detection of microbial contamination within meat utilizing a smartphone-based biosensor. Sci Rep, 4:5953.

[45]LongKD, WoodburnEV, LeHM, et al., 2017. Multimode smartphone biosensing: the transmission, reflection, and intensity spectral (TRI)-analyzer. Lab Chip, 17(19):3246-3257.

[46]LukinavičiusG, UmezawaK, OlivierN, et al., 2013. A near-infrared fluorophore for live-cell super-resolution microscopy of cellular proteins. Nat Chem, 5(2):132-139.

[47]LuoJD, XieZL, LamJWY, et al., 2001. Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole. Chem Commun, 36(18):1740-1741.

[48]LuoSL, ZhangEL, SuYP, et al., 2011. A review of NIR dyes in cancer targeting and imaging. Biomaterials, 32(29):7127-7138.

[49]MännikJ, WuFB, HolFJH, et al., 2012. Robustness and accuracy of cell division in Escherichia coli in diverse cell shapes. Proc Natl Acad Sci USA, 109(18):6957-6962.

[50]MarshallMV, RasmussenJC, TanIC, et al., 2010. Near-infrared fluorescence imaging in humans with indocyanine green: a review and update. Open Surg Oncol J, 2(2):12-25.

[51]McAuliffeKJ, KasterMA, SzlagRG, et al., 2017. Low-symmetry mixed fluorinated subphthalocyanines as fluorescence imaging probes in MDA-MB-231 breast tumor cells. Int J Mol Sci, 18(6):1177.

[52]McCartneyP, 2014. Smart phones transform patient-centered telemedicine. MCN, 39(6):382.

[53]McGonigleAJS, WilkesTC, PeringTD, et al., 2018. Smartphone spectrometers. Sensors (Basel), 18(1):223.

[54]MeiJ, LeungNLC, KwokRTK, et al., 2015. Aggregation-induced emission: together we shine, united we soar! Chem Rev, 115(21):11718-11940.

[55]MichaelB, 2010. Optical Properties of Films and Coatings Handbook of Optics: Volume IV-Optical Properties of Materials, Nonlinear Optics, Quantum Optics, 3rd Ed. McGraw Hill Professional, Access Engineering.

[56]MierauI, KleerebezemM, 2005. 10 years of the nisin-controlled gene expression system (NICE) in Lactococcus lactis. Appl Microbiol Biotechnol, 68(6):705-717.

[57]MiricaKA, ShevkoplyasSS, PhillipsST, et al., 2009. Measuring densities of solids and liquids using magnetic levitation: fundamentals. J Am Chem Soc, 131(29):10049-10058.

[58]NemiroskiA, KumarAA, SohS, et al., 2016. High-sensitivity measurement of density by magnetic levitation. Anal Chem, 88(5):2666-2674.

[59]NeumanBP, EiflerJB, CastanaresM, et al., 2015. Real-time, near-infrared fluorescence imaging with an optimized dye/light source/camera combination for surgical guidance of prostate cancer. Clin Cancer Res, 21(4):771-780.

[60]OwensEA, HenaryM, el FakhriG, et al., 2016. Tissue-specific near-infrared fluorescence imaging. Acc Chem Res, 49(9):1731-1740.

[61]PanH, ZhangPF, GaoDY, et al., 2014. Noninvasive visualization of respiratory viral infection using bioorthogonal conjugated near-infrared-emitting quantum dots. ACS Nano, 8(6):5468-5477.

[62]PansareVJ, HejaziS, FaenzaWJ, et al., 2012. Review of long-wavelength optical and NIR imaging materials: contrast agents, fluorophores, and multifunctional nano carriers. Chem Mater, 24(5):812-827.

[63]PügnerT, KnobbeJ, GrügerH, 2016. Near-infrared grating spectrometer for mobile phone applications. Appl Spectrosc, 70(5):734-745.

[64]QiP, ZhangD, SunY, et al., 2016. A selective near-infrared fluorescent probe for hydrogen sulfide and its application in sulfate-reducing bacteria detection. Anal Methods, 8(16):3339-3344.

[65]RateniG, DarioP, CavalloF, 2017. Smartphone-based food diagnostic technologies: a review. Sensors (Basel), 17(6):1453.

[66]RolfeP, 2000. In vivo near-infrared spectroscopy. Annu Rev Biomed Eng, 2:715-754.

[67]SafaieJ, GrebeR, MoghaddamHA, et al., 2013. Wireless distributed acquisition system for near infrared spectroscopy—WDA-NIRS. J Innov Opt Health Sci, 6(3):1350019.

[68]SakudaT, KuboT, JohanMP, et al., 2019. Novel near-infrared fluorescence-guided surgery with vesicular stomatitis virus for complete surgical resection of osteosarcomas in mice. J Orthop Res, 37(5):1192-1201.

[69]SchaafsmaBE, MieogJSD, HuttemanM, et al., 2011. The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery. J Surg Oncol, 104(3):323-332.

[70]ScottAS, BaltzanMA, WolkoveN, 2014. Examination of pulse oximetry tracings to detect obstructive sleep apnea in patients with advanced chronic obstructive pulmonary disease. Can Respir J, 21:948717.

[71]Sevick-MuracaEM, SharmaR, RasmussenJC, et al., 2008. Imaging of lymph flow in breast cancer patients after microdose administration of a near-infrared fluorophore: feasibility study. Radiology, 246(3):734-741.

[72]ShcherbakovaDM, BalobanM, EmelyanovAV, et al., 2016. Bright monomeric near-infrared fluorescent proteins as tags and biosensors for multiscale imaging. Nat Commun, 7:12405.

[73]ShcherboD, ShemiakinaII, RyabovaAV, et al., 2010. Near-infrared fluorescent proteins. Nat Methods, 7(10):827-829.

[74]ShiehP, SiegristMS, CullenAJ, et al., 2014. Imaging bacterial peptidoglycan with near-infrared fluorogenic azide probes. Proc Natl Acad Sci USA, 111(15):5456-5461.

[75]ShuXK, RoyantA, LinMZ, et al., 2009. Mammalian expression of infrared fluorescent proteins engineered from a bacterial phytochrome. Science, 324(5928):804-807.

[76]SlettenEM, BertozziCR, 2009. Bioorthogonal chemistry: fishing for selectivity in a sea of functionality. Angew Chem Int Ed, 48(38):6974-6998.

[77]SmithZJ, ChuKQ, EspensonAR, et al., 2011. Cell-phone-based platform for biomedical device development and education applications. PLoS ONE, 6(3):e17150.

[78]StoyeJP, CoffinJM, 1988. Polymorphism of murine endogenous proviruses revealed by using virus class-specific oligonucleotide probes. J Virol, 62(1):168-175.

[79]StrangmanG, FranceschiniMA, BoasDA, 2003. Factors affecting the accuracy of near-infrared spectroscopy concentration calculations for focal changes in oxygenation parameters. NeuroImage, 18(4):865-879.

[80]SureshN, TangQG, LiuY, et al., 2018. Characterization and in vivo application of mobile phones for near-infrared fluorescence imaging of tumors. Proceedings of Frontiers in Optics 2018, Washington DC, USA.

[81]TanX, LuoSL, LongL, et al., 2017. Structure-guided design and synthesis of a mitochondria-targeting near-infrared fluorophore with multimodal therapeutic activities. Adv Mater, 29(43):1704196.

[82]TangR, XueJP, XuBG, et al., 2015. Tunable ultrasmall visible-to-extended near-infrared emitting silver sulfide quantum dots for integrin-targeted cancer imaging. ACS Nano, 9(1):220-230.

[83]TroyanSL, KianzadV, Gibbs-StraussSL, et al., 2009. The FLARETM intraoperative near-infrared fluorescence imaging system: a first-in-human clinical trial in breast cancer sentinel lymph node mapping. Ann Surg Oncol, 16(10):2943-2952.

[84]UranoY, AsanumaD, HamaY, et al., 2008. Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes. Nat Med, 15:104-109.

[85]VaithianathanT, TullisIDC, EverdellN, et al., 2004. Design of a portable near infrared system for topographic imaging of the brain in babies. Rev Sci Instrum, 75(10):3276-3283.

[86]VanegasM, CarpS, FangQQ, 2018. Mobile phone camera based near-infrared spectroscopy measurements. Proceedings of Clinical and Translational Biophotonics 2018, Hollywood, Florida, USA.

[87]VentolaCL, 2014. Mobile devices and apps for health care professionals: uses and benefits. P T, 39(5):356-364.

[88]WangP, RobertL, PelletierJ, et al., 2010. Robust growth of Escherichia coli. Curr Biol, 20(12):1099-1103.

[89]WatanabeT, SekineR, MizunoT, et al., 2016. Development of portable, wireless and smartphone controllable near-infrared spectroscopy system. In: Luo QM, Li LZ, Harrison DK, et al. (Eds.), Oxygen Transport to Tissue XXXVIII. Springer, Cham, p.385-392.

[90]WeiQS, QiHF, LuoW, et al., 2013. Fluorescent imaging of single nanoparticles and viruses on a smart phone. ACS Nano, 7(10):9147-9155.

[91]WeiQS, LuoW, ChiangS, et al., 2014. Imaging and sizing of single DNA molecules on a mobile phone. ACS Nano, 8(12):12725-12733.

[92]WilkesTC, McGonigleAJS, WillmottJR, et al., 2017. Low-cost 3D printed 1 nm resolution smartphone sensor-based spectrometer: instrument design and application in ultraviolet spectroscopy. Opt Lett, 42(21):4323-4326.

[93]WuFB, van RijnE, van SchieBGC, et al., 2015a. Multi-color imaging of the bacterial nucleoid and division proteins with blue, orange, and near-infrared fluorescent proteins. Front Microbiol, 6:607.

[94]WuFB, van SchieBGC, KeymerJE, et al., 2015b. Symmetry and scale orient Min protein patterns in shaped bacterial sculptures. Nat Nanotechnol, 10(8):719-726.

[95]YooJH, 2013. The meaning of information technology (IT) mobile devices to me, the infectious disease physician. Infect Chemother, 45(2):244-251.

[96]ZhangCL, AnzaloneNC, FariaRP, et al., 2013. Open-source 3D-printable optics equipment. PLoS ONE, 8(3):e59840.

[97]ZhangY, SunJW, WeiG, et al., 2009. Design of a portable near infra-red spectroscopy system for tissue oxygenation measurement. Proceedings of the 3rd International Conference on Bioinformatics and Biomedical Engineering, Beijing, China.

[98]ZhaoEG, ChenYL, WangH, et al., 2015a. Light-enhanced bacterial killing and wash-free imaging based on AIE fluorogen. ACS Appl Mater Interfaces, 7(13):7180-7188.

[99]ZhaoEG, ChenYL, ChenSJ, et al., 2015b. A luminogen with aggregation-induced emission characteristics for wash-free bacterial imaging, high-throughput antibiotics screening and bacterial susceptibility evaluation. Adv Mater, 27(33):4931-4937.

[100]ZhaoJY, ZhongD, ZhouSB, 2018. NIR-I-to-NIR-II fluorescent nanomaterials for biomedical imaging and cancer therapy. J Mater Chem B, 6(3):349-365.

[101]ZhouJ, YangF, JiangGC, et al., 2016. Applications of indocyanine green based near-infrared fluorescence imaging in thoracic surgery. J Thorac Dis, 8(S9):S738-S743.

[102]ZhouXX, LiWF, MaGX, et al., 2006. The nisin-controlled gene expression system: construction, application and improvements. Biotechnol Adv, 24(3):285-295.

[103]ZhuB, Sevick-MuracaEM, 2015. A review of performance of near-infrared fluorescence imaging devices used in clinical studies. Br J Radiol, 88(1045):20140547.

[104]ZhuBH, RasmussenJC, LuYJ, et al., 2010. Reduction of excitation light leakage to improve near-infrared fluorescence imaging for tissue surface and deep tissue imaging. Med Phys, 37(11):5961-5970.

[105]ZhuHY, YaglidereO, SuTW, et al., 2011a. Cost-effective and compact wide-field fluorescent imaging on a cell-phone. Lab Chip, 11(2):315-322.

[106]ZhuHY, MavandadiS, CoskunAF, et al., 2011b. Optofluidic fluorescent imaging cytometry on a cell phone. Analy Chem, 83(17):6641-6647.

[107]ZhuHY, YaglidereO, SuTW, et al., 2011c. Wide-field fluorescent microscopy on a cell-phone. Proceedings of Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Boston, MA, USA.

[108]ZhuHY, SikoraU, OzcanA, 2012. Quantum dot enabled detection of Escherichia coli using a cell-phone. Analyst, 137(11):2541-2544.

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