Similar articles

Abstract: This systematic review and meta-analysis considered the results of randomized controlled clinical trials (RCTs) to evaluate the efficacy of systemic or local antibiotic therapy in peri-implantitis. Two independent authors screened publications from three electronic databases to include RCTs meeting all the inclusion and exclusion criteria. A meta-analysis was performed to evaluate the weighted mean differences in survival rate (SR) and changes in pocket probing depth (PPD), bone level (BL), and clinical attachment level (CAL). The study cohorts were defined as antibiotic and control groups with subgroups for analysis. Seven studies including 309 patients (390 implants) were considered. Within the limitations of this review, patients in the antibiotic groups exhibited significant improvements in PPD. Subgroup analysis indicated that the administration of systemic antibiotics or the use of antibiotics in non-surgical treatments did not result in a significant alteration in BL. It was established that the addition of antibiotics can ameliorate PPD and SR in the treatment of peri-implantitis, whether through surgical or non-surgical approaches, and also shows moderate performance regarding BL and CAL. Considering the lack of application of new technologies in the control group and the hardship of assessing the potential risks of antibiotics, careful clinical judgment is still necessary.

全身或局部辅助使用抗生素在种植体周围炎治疗中的疗效：随机对照临床试验的系统综述和荟萃分析

[1]AlvesCH, RussiKL, RochaNC, et al., 2022. Host-microbiome interactions regarding peri-implantitis and dental implant loss. J Transl Med, 20:425.

[2]Baus-DomínguezM, BakkaliS, Hermida-CabreraP, et al., 2023. A systematic review and meta-analysis of systemic and local antibiotic therapy in the surgical treatment of peri-implantitis. Antibiotics, 12(7):1223.

[3]BerglundhT, ArmitageG, AraujoMG, et al., 2018. Peri-implant diseases and conditions: consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Clin Periodontol, 45(S20):S286-S291.

[4]BlancoC, PicoA, DopicoJ, et al., 2022. Adjunctive benefits of systemic metronidazole on non-surgical treatment of peri-implantitis. A randomized placebo-controlled clinical trial. J Clin Periodontol, 49(1):15-27.

[5]BocciaG, di SpiritoF, D'AmbrosioF, et al., 2023. Local and systemic antibiotics in peri-implantitis management: an umbrella review. Antibiotics, 12(1):114.

[6]CarcuacO, DerksJ, CharalampakisG, et al., 2016. Adjunctive systemic and local antimicrobial therapy in the surgical treatment of peri-implantitis: a randomized controlled clinical trial. J Dent Res, 95(1):50-57.

[7]CarcuacO, DerksJ, AbrahamssonI, et al., 2017. Surgical treatment of peri-implantitis: 3-year results from a randomized controlled clinical trial. J Clin Periodontol, 44(12):1294-1303.

[8]ChaJK, LeeJS, KimCS, 2019. Surgical therapy of peri-implantitis with local minocycline: a 6-month randomized controlled clinical trial. J Dent Res, 98(3):288-295.

[9]ChanHL, LinGH, SuarezF, et al., 2014. Surgical management of peri-implantitis: a systematic review and meta-analysis of treatment outcomes. J Periodontol, 85(8):1027-1041.

[10]ChenQM, WangYH, ShuaiJ, 2023. Current status and future prospects of stomatology research. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 24(10):853-867.

[11]ClaffeyN, ClarkeE, PolyzoisI, et al., 2008. Surgical treatment of peri-implantitis. J Clin Periodontol, 35(s8):316-332.

[12]DarbyI, 2022. Risk factors for periodontitis & peri-implantitis. Periodontol 2000, 90(1):9-12.

[13]DerksJ, TomasiC, 2015. Peri-implant health and disease. A systematic review of current epidemiology. J Clin Periodontol, 42(S16):S158-S171.

[14]EmanuelN, MachteiEE, ReichartM, et al., 2020. D-PLEX₅₀₀: a local biodegradable prolonged release doxycycline-formulated bone graft for the treatment for peri-implantitis. A randomized controlled clinical study. Quintessence Int, 51(7):546-553.

[15]FeresM, MartinsR, SouzaJGS, et al., 2023. Unraveling the effectiveness of antibiotics for peri-implantitis treatment: a scoping review. Clin Implant Dent Relat Res, 25(4):767-781.

[16]FigueroE, GrazianiF, SanzI, et al., 2014. Management of peri-implant mucositis and peri-implantitis. Periodontol 2000, 66(1):255-273.

[17]GrazianiF, KarapetsaD, AlonsoB, et al., 2017. Nonsurgical and surgical treatment of periodontitis: how many options for one disease? Periodontol 2000, 75(1):152-188.

[18]GrusovinMG, PisperoA, del FabbroM, et al., 2022. Antibiotics as adjunctive therapy in the non-surgical treatment of peri-implantitis: a systematic review and meta-analysis. Antibiotics, 11(12):1766.

[19]Heitz-MayfieldLJ, AaboeM, AraujoM, et al., 2018. Group 4 ITI consensus report: risks and biologic complications associated with implant dentistry. Clin Oral Implants Res, 29(S16):351-358.

[20]Heitz-MayfieldLJA, MombelliA, 2014. The therapy of peri-implantitis: a systematic review. Int J Oral Maxillofac Implants, 29(Suppl):325-345.

[21]HigginsJPT, ThompsonSG, DeeksJJ, et al., 2003. Measuring inconsistency in meta-analyses. BMJ, 327(7414):‍‍557-560.

[22]HigginsJPT, AltmanDG, GøtzschePC, et al., 2011. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ, 343:d5928.

[23]KeestraJAJ, GrosjeanI, CouckeW, et al., 2015. Non-surgical periodontal therapy with systemic antibiotics in patients with untreated chronic periodontitis: a systematic review and meta-analysis. J Periodontal Res, 50(3):294-314.

[24]KhoshkamV, ChanHL, LinGH, et al., 2013. Reconstructive procedures for treating peri-implantitis: a systematic review. J Dent Res, 92(12 Suppl):131S-138S.

[25]KlingeB, GustafssonA, BerglundhT, 2002. A systematic review of the effect of anti-infective therapy in the treatment of peri-implantitis. J Clin Periodontol, 29(s3):‍213-225.

[26]LeeCT, HuangYW, ZhuL, et al., 2017. Prevalences of peri-implantitis and peri-implant mucositis: systematic review and meta-analysis. J Dent, 62:1-12.

[27]LiZB, LiK, DingT, et al., 2022. The effect of nonaugmentative approaches in the surgical treatment of peri-implantitis: a systematic review and network meta-analysis. Int J Oral Maxillofac Implants, 37(2):270-282.

[28]LiñaresA, Sanz-SánchezI, DopicoJ, et al., 2023. Efficacy of adjunctive measures in the non-surgical treatment of peri-implantitis: a systematic review. J Clin Periodontol, 50(S26):224-243.

[29]LuHL, TangHF, ZhouT, et al., 2018. Assessment of the periodontal health status in patients undergoing orthodontic treatment with fixed appliances and Invisalign system: a meta-analysis. Medicine, 97(13):e0248.

[30]MombelliA, LangNP, 1992. Antimicrobial treatment of peri-implant infections. Clin Oral Implants Res, 3(4):162-168.

[31]ParkSH, SongYW, ChaJK, et al., 2021. Adjunctive use of metronidazole-minocycline ointment in the nonsurgical treatment of peri-implantitis: a multicenter randomized controlled trial. Clin Implant Dent Relat Res, 23(4):‍543-554.

[32]PassarelliPC, NettiA, LopezMA, et al., 2021. Local/topical antibiotics for peri-implantitis treatment: a systematic review. Antibiotics, 10(11):1298.

[33]PolymeriA, van der HorstJ, Anssari MoinD, et al., 2022. Non-surgical peri-implantitis treatment with or without systemic antibiotics: a randomized controlled clinical trial. Clin Oral Implants Res, 33(5):548-557.

[34]RenvertS, Roos-JansåkerAM, LindahlC, et al., 2007. Infection at titanium implants with or without a clinical diagnosis of inflammation. Clin Oral Implants Res, 18(4):509-516.

[35]RovaiES, SoutoMLS, GanhitoJA, et al., 2016. Efficacy of local antimicrobials in the non-surgical treatment of patients with periodontitis and diabetes: a systematic review. J Periodontol, 87(12):1406-1417.

[36]SantosRS, MacedoRF, SouzaEA, et al., 2016. The use of systemic antibiotics in the treatment of refractory periodontitis: a systematic review. J Am Dent Assoc, 147(7):577-585.

[37]ShibliJA, FerrariDS, SiromaRS, et al., 2019. Microbiological and clinical effects of adjunctive systemic metronidazole and amoxicillin in the non-surgical treatment of peri-implantitis: 1 year follow-up. Braz Oral Res, 33(S1):e080.

[38]SinghR, SripadaL, SinghR, 2014. Side effects of antibiotics during bacterial infection: mitochondria, the main target in host cell. Mitochondrion, 16:50-54.

[39]SmeetsR, HenningsenA, JungO, et al., 2014. Definition, etiology, prevention and treatment of peri-implantitis ‍‒ a review. Head Face Med, 10:34.

[40]TeughelsW, SeyssensL, ChristiaensV, et al., 2023. Adjunctive locally and systemically delivered antimicrobials during surgical treatment of peri-implantitis: a systematic review. J Clin Periodontol, 50(S26):359-372.

[41]VerdugoF, LaksmanaT, UribarriA, 2016. Systemic antibiotics and the risk of superinfection in peri-implantitis. Arch Oral Biol, 64:39-50.

[42]VilarrasaJ, SoldiniMC, PonsR, et al., 2023. Outcome indicators of non-surgical therapy of peri-implantitis: a prospective case series analysis. Clin Oral Investig, 27(6):3125-3138.

[43]WangY, ChenCY, StathopoulouPG, et al., 2022. Efficacy of antibiotics used as an adjunct in the treatment of peri-implant mucositis and peri-implantitis: a systematic review and meta-analysis. Int J Oral Maxillofac Implants, 37(2):235-249.

[44]YongJW, GrögerS, von BremenJ, et al., 2023. Photobiomodulation therapy assisted orthodontic tooth movement: potential implications, challenges, and new perspectives. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 24(11):‍957-973.

[45]ZhangHD, LiWJ, ZhangL, et al., 2018. A nomogram prediction of peri-implantitis in treated severe periodontitis patients: a 1‍‒‍5-year prospective cohort study. Clin Implant Dent Relat Res, 20(6):962-968.

[46]ZhaoXT, LinHB, DingT, et al., 2023. Overview of the main biological mechanisms linked to changes in periodontal ligament stem cells and the inflammatory microenvironment. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 24(5):373-386.

[47]ZhaoYX, PuR, QianYJ, et al., 2021. Antimicrobial photodynamic therapy versus antibiotics as an adjunct in the treatment of periodontitis and peri-implantitis: a systematic review and meta-analysis. Photodiagnosis Photodyn Ther, 34:102231.

[48]ZitzmannNU, BerglundhT, MarinelloCP, et al., 2001. Experimental peri-implant mucositis in man. J Clin Periodontol, 28(6):517-523.