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On-line Access: 2022-08-12

Received: 2022-03-23

Revision Accepted: 2022-05-31

Crosschecked: 2022-08-12

Cited: 0

Clicked: 259

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Fan Qu

https://orcid.org/0000-0003-1851-1514

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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.8 P.655-665

http://doi.org/10.1631/jzus.B2200154


Impact of COVID-19 pandemic on the pregnancy outcomes of women undergoing assisted reproductive techniques (ARTs): a systematic review and meta-analysis


Author(s):  Weihuan HU, Yuhang ZHU, Yan WU, Fangfang WANG, Fan QU

Affiliation(s):  Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China; more

Corresponding email(s):   syqufan@zju.edu.cn

Key Words:  Systematic review, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Assisted reproductive technique (ART), Pregnancy outcome, Meta-analysis


Weihuan HU, Yuhang ZHU, Yan WU, Fangfang WANG, Fan QU. Impact of COVID-19 pandemic on the pregnancy outcomes of women undergoing assisted reproductive techniques (ARTs): a systematic review and meta-analysis[J]. Journal of Zhejiang University Science B, 2022, 23(8): 655-665.

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author="Weihuan HU, Yuhang ZHU, Yan WU, Fangfang WANG, Fan QU",
journal="Journal of Zhejiang University Science B",
volume="23",
number="8",
pages="655-665",
year="2022",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2200154"
}

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%T Impact of COVID-19 pandemic on the pregnancy outcomes of women undergoing assisted reproductive techniques (ARTs): a systematic review and meta-analysis
%A Weihuan HU
%A Yuhang ZHU
%A Yan WU
%A Fangfang WANG
%A Fan QU
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T1 - Impact of COVID-19 pandemic on the pregnancy outcomes of women undergoing assisted reproductive techniques (ARTs): a systematic review and meta-analysis
A1 - Weihuan HU
A1 - Yuhang ZHU
A1 - Yan WU
A1 - Fangfang WANG
A1 - Fan QU
J0 - Journal of Zhejiang University Science B
VL - 23
IS - 8
SP - 655
EP - 665
%@ 1673-1581
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2200154


Abstract: 
The global outbreak of the coronavirus disease 2019 (COVID-19) led to the suspension of most treatments with assisted reproductive technique (ART). However, with the recent successful control of the pandemic in China, there is an urgent public need to resume full reproductive care. To determine whether the COVID-19 pandemic had any adverse effects on female fertility and the pregnancy outcomes of women undergoing ART, a systematic review and meta-analysis was conducted using the electronic Chinese and English databases. Dichotomous outcomes were summarized as prevalence, and odds ratios (ORs) and continuous outcomes as standardized mean difference (SMD) with 95% confidence interval (CI). The risk of bias and subgroup analyses were assessed using Stata/SE 15.1 and R 4.1.2. The results showed that compared with women treated by ART in the pre-COVID-19 time frame, women undergoing ART after the COVID-19 pandemic exhibited no significant difference in the clinical pregnancy rate (OR 1.07, 95% CI 0.97 to 1.19; I2=0.0%), miscarriage rate (OR 0.95, 95% CI 0.79 to 1.14; I2=38.4%), embryo cryopreservation rate (OR 2.90, 95% CI 0.17 to 48.13; I2=85.4%), and oocyte cryopreservation rate (OR 0.30, 95% CI 0.03 to 3.65; I2=81.6%). This review provided additional evidence for gynecologists to guide the management of women undergoing ART treatment during the COVID-19 pandemic timeframe.

COVID-19大流行对接受辅助生殖技术(ART)的妇女妊娠结局的影响:系统评价和荟萃分析

胡蔚桓1,2,朱宇航1,吴琰1,王芳芳1,曲凡1
1浙江大学医学院附属妇产科医院,中国杭州,310006
2大连医科大学,中国大连,116000
目的:2019年全球新型冠状病毒病肺炎(COVID-19)的爆发导致大多数辅助生殖技术(ART)治疗的暂停。然而,随着最近中国成功控制了大流行,公众迫切需要恢复全面的生殖保健。因此,本文讨论COVID-19大流行是否对女性生育能力和接受ART治疗的妇女的妊娠结局有任何不利影响。
方法:使用中英文电子数据库进行了系统评价和荟萃分析。二分类结局总结为患病率和比值比(OR),连续结局总结为标准化均数差(SMD),置信度为95%。使用Stata/SE 15.1和R 4.1.2评估偏倚风险和亚组分析。
结论:结果显示,与COVID-19前接受ART治疗的妇女相比,COVID-19大流行后接受ART治疗的妇女在临床妊娠率(1.07,0.97~1.19;I2=0.0%)、流产率(0.95,0.79~1.14;I2=38.4%)、胚胎冷冻保存率(2.90,0.17~48.13;I2=85.4%)和卵母细胞冷冻保留率(0.30,0.03~3.65;I2=81.6%)等方面没有显著差异。该评价为妇科医生提供了额外的证据,以指导在COVID-19大流行期间接受ART治疗的妇女的管理。

关键词:系统综述;新型冠状病毒病肺炎(COVID-19);严重急性呼吸系统综合征冠状病毒2(SARS-CoV-2);辅助生殖技术(ART);妊娠结局;荟萃分析

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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