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On-line Access: 2022-08-12

Received: 2022-03-23

Revision Accepted: 2022-05-31

Crosschecked: 2022-08-12

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Fan Qu


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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.8 P.655-665


Impact of COVID-19 pandemic on the pregnancy outcomes of women undergoing assisted reproductive techniques (ARTs): a systematic review and meta-analysis

Author(s):  Weihuan HU, Yuhang ZHU, Yan WU, Fangfang WANG, Fan QU

Affiliation(s):  Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China; more

Corresponding email(s):   syqufan@zju.edu.cn

Key Words:  Systematic review, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Assisted reproductive technique (ART), Pregnancy outcome, Meta-analysis

Weihuan HU, Yuhang ZHU, Yan WU, Fangfang WANG, Fan QU. Impact of COVID-19 pandemic on the pregnancy outcomes of women undergoing assisted reproductive techniques (ARTs): a systematic review and meta-analysis[J]. Journal of Zhejiang University Science B, 2022, 23(8): 655-665.

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author="Weihuan HU, Yuhang ZHU, Yan WU, Fangfang WANG, Fan QU",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Impact of COVID-19 pandemic on the pregnancy outcomes of women undergoing assisted reproductive techniques (ARTs): a systematic review and meta-analysis
%A Weihuan HU
%A Yuhang ZHU
%A Yan WU
%A Fangfang WANG
%A Fan QU
%J Journal of Zhejiang University SCIENCE B
%V 23
%N 8
%P 655-665
%@ 1673-1581
%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2200154

T1 - Impact of COVID-19 pandemic on the pregnancy outcomes of women undergoing assisted reproductive techniques (ARTs): a systematic review and meta-analysis
A1 - Weihuan HU
A1 - Yuhang ZHU
A1 - Yan WU
A1 - Fangfang WANG
A1 - Fan QU
J0 - Journal of Zhejiang University Science B
VL - 23
IS - 8
SP - 655
EP - 665
%@ 1673-1581
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2200154

The global outbreak of the coronavirus disease 2019 (COVID-19) led to the suspension of most treatments with assisted reproductive technique (ART). However, with the recent successful control of the pandemic in China, there is an urgent public need to resume full reproductive care. To determine whether the COVID-19 pandemic had any adverse effects on female fertility and the pregnancy outcomes of women undergoing ART, a systematic review and meta-analysis was conducted using the electronic Chinese and English databases. Dichotomous outcomes were summarized as prevalence, and odds ratios (ORs) and continuous outcomes as standardized mean difference (SMD) with 95% confidence interval (CI). The risk of bias and subgroup analyses were assessed using Stata/SE 15.1 and R 4.1.2. The results showed that compared with women treated by ART in the pre-COVID-19 time frame, women undergoing ART after the COVID-19 pandemic exhibited no significant difference in the clinical pregnancy rate (OR 1.07, 95% CI 0.97 to 1.19; I2=0.0%), miscarriage rate (OR 0.95, 95% CI 0.79 to 1.14; I2=38.4%), embryo cryopreservation rate (OR 2.90, 95% CI 0.17 to 48.13; I2=85.4%), and oocyte cryopreservation rate (OR 0.30, 95% CI 0.03 to 3.65; I2=81.6%). This review provided additional evidence for gynecologists to guide the management of women undergoing ART treatment during the COVID-19 pandemic timeframe.


方法:使用中英文电子数据库进行了系统评价和荟萃分析。二分类结局总结为患病率和比值比(OR),连续结局总结为标准化均数差(SMD),置信度为95%。使用Stata/SE 15.1和R 4.1.2评估偏倚风险和亚组分析。


Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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