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Journal of Zhejiang University SCIENCE A 2000 Vol.1 No.3 P.342-346

http://doi.org/10.1631/jzus.2000.0342


EFFECT OF OVARIAN STIMULATION WITH OR WITHOUT GnRH AGONIST ON HAMSTER ENDOMETRIAL SECRETION


Author(s):  HUANG He-feng, XIA Ya-xian, SHI Yi-fu, ZHOU Fu-zhen

Affiliation(s):  Dept.of Obstetrics & Gynecology, Women's Hospital, Medical College, Zhejiang University, Hangzhou 310006,China; more

Corresponding email(s): 

Key Words:  GnRHa. protein. endometrium. hamster


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HUANG He-feng, XIA Ya-xian, SHI Yi-fu, ZHOU Fu-zhen. EFFECT OF OVARIAN STIMULATION WITH OR WITHOUT GnRH AGONIST ON HAMSTER ENDOMETRIAL SECRETION[J]. Journal of Zhejiang University Science A, 2000, 1(3): 342-346.

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journal="Journal of Zhejiang University Science A",
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publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2000.0342"
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A1 - HUANG He-feng
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A1 - ZHOU Fu-zhen
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Abstract: 
The present study was undertaken to evaluate the endometrial secretion and synthesis of proteins in hamsters that were subjected to ovarian stimulation with or without GnRH agonist (Leuprolide Acetate, LA). The results of protein resolution revealed that the molecular weight of the proteins increased from 31D to 66D, while the intensities of photographed protein bands in the hamsters treated with LA and pregnant mare's serum gonadotropin (PMSG) were less than that in those treated with PMSG alone. The amounts of low and medium weights (31kD and 45kD) proteins newly synthesized in LA+PMSG group and saline group (control) were significantly higher than that in PMSG group. The synthesized and secreted proteins in groups LA and control were similar. The data suggested that a physiologic endometrial protein secretory and synthetic change with GnRH agonist regarcded as a possible cause of the higher pregnancy rate in in vitro fertilization. The degree of endometrial secretion and synthesis varied considerably with the type of ovarian stimulation used.

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Reference

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[2]Biljan, M.M. and Tan, S.L., 1997. GnRH ago nists in gonadotropin ovulation induction: characteristicsof long regimens. Presented at the Proceedings of the 2nd World Conference on Ovulation Induction. Bologna, p.75-82.

[3]Daya, S., 1997. Optimal protocol for gonadotropin releasing hormone agonist use in ovarian stimulation. Presented at 10th World Congress on In: Vitro Fertilization and Assisted Conception. Vancouver, p.405-410.

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