Full Text:   <2347>

CLC number: R575

On-line Access: 

Received: 2001-12-26

Revision Accepted: 2002-01-21

Crosschecked: 0000-00-00

Cited: 0

Clicked: 5126

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
1. Reference List
Open peer comments

Journal of Zhejiang University SCIENCE A 2002 Vol.3 No.3 P.374-377


Ultra-Cut biopsy guided by ultrasonography for liver lesions: experience of 392 clinical cases

Author(s):  PAN Hong-ming, FAN xiao-ming, WANG Hai-yun, WU Jin-min

Affiliation(s):  Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China

Corresponding email(s):   panhongming@163.net

Key Words:  Liver, Neoplasms, Biopsy, Ultrasonography

Share this article to: More

PAN Hong-ming, FAN xiao-ming, WANG Hai-yun, WU Jin-min. Ultra-Cut biopsy guided by ultrasonography for liver lesions: experience of 392 clinical cases[J]. Journal of Zhejiang University Science A, 2002, 3(3): 374-377.

@article{title="Ultra-Cut biopsy guided by ultrasonography for liver lesions: experience of 392 clinical cases",
author="PAN Hong-ming, FAN xiao-ming, WANG Hai-yun, WU Jin-min",
journal="Journal of Zhejiang University Science A",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Ultra-Cut biopsy guided by ultrasonography for liver lesions: experience of 392 clinical cases
%A PAN Hong-ming
%A FAN xiao-ming
%A WANG Hai-yun
%A WU Jin-min
%J Journal of Zhejiang University SCIENCE A
%V 3
%N 3
%P 374-377
%@ 1869-1951
%D 2002
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2002.0374

T1 - Ultra-Cut biopsy guided by ultrasonography for liver lesions: experience of 392 clinical cases
A1 - PAN Hong-ming
A1 - FAN xiao-ming
A1 - WANG Hai-yun
A1 - WU Jin-min
J0 - Journal of Zhejiang University Science A
VL - 3
IS - 3
SP - 374
EP - 377
%@ 1869-1951
Y1 - 2002
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2002.0374

We conducted a retrospective study of the accuracy of liver biopsies in 392 patients with liver lesions. Postbiopsy diagnosis was 297 cases of primary liver cancers, 79 cases of secondary malignant tumors, 2 cases of non-Hodgkin's lymphoma, 10 cases of focal nodular hyperplasia, 2 cases of chronic inflammation, 1 tuberculosis case and 1 schistosomiasis case. biopsy provided histological diagnosis in 100% of cases, sensibility and specificity of Ultra-Cut biopsy was 98.95% and 100% for the diagnosis of malignancy respectively; positive predictive value, 100%; negative predictive value, 71.43%; and accuracy, 98.98%. We identified no major procedure related complications despite the presence of thrombocytopenia in 37.5% of cases. Pain was the only reported adverse effect of liver biopsy (10.97%), and 11 patients required analgesics. We concluded that Ultra-Cut liver biopsy was a safe and effective technique, and was invaluable in the investigation and management of patients with liver lesions.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


[1] Ahmad, M., Riley, T.R., 2001. Can one predict when ultrasound will be useful with percutaneous liver biopsy? Am J Gastroenterol, 96(2): 547-549.

[2] Bravo, A.A., Sheth, S.G., Chopra, S., 2001. Liver biopsy. N Engl J Med, 344(7):495-500.

[3] Brown, K.E.,Janey, C.G.,Brunt, E.M., 2000. Liver biopsy: indications, technique, complications, and interpretation. In: Liver disease: diagnosis and management, Ed. by Bacon B.R., Di Bisceglie A.M. Churchill Livingstone, New York.

[4] Hosten, N., Puls, R., Bechstein, W.O., Felix, R., 1999. Focal liver lesions: Doppler ultrasound. Eur Radiol, 9:428-435.

[5] Janes, C.H., Lindor, K.D., 1993.Outcome of patients hospitalized for complications of liver biopsy after outpatient liver biopsy. Ann Intern Med, 118:96-98.

[6] Mladinich, C.R.J., Ackerman, N., Berry, C., 1992. Evaluation and comparison of automated biopsy devices. Radiology, 184:845-847.

[7] Piccinino, F., Sagnelli, E., Pasquae, G., Giusti, G., 1986.Complications following percutaneous liver biopsy: a multicentre retrospective study on 68276 biopsies. J. Hepatol, 2:165-173.

[8] Ward, J., Naik K.S., Guthrie, J.A., Wilson, D., Robinson, P.J., 1999. Hepatic lesion detection: Comparison of MR imaging after the administration of superparamagnetic iron oxide with dual-phase CT by using alternative-free response receiver operating characteristic analysis. Radiology, 210:459-466.

[9] Yu, S. C.H., Liew, C. T., Lau, W.Y., Leung, T.W., 2001. Us-guided percutaneous biopsy of small(≤1cm) hepatic lesions. Radiol, 218(1): 195-199.

Open peer comments: Debate/Discuss/Question/Opinion


Please provide your name, email address and a comment

Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2024 Journal of Zhejiang University-SCIENCE