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Journal of Zhejiang University SCIENCE A 2003 Vol.4 No.5 P.616-619


Antiphospholipid syndrome:a survey of clinical characters in ten cases

Author(s):  CHEN Li-hua, JIANG Ling-ling, LI You-ming, PENG Qing-bi

Affiliation(s):  Department of Internal Medicine, First Affiliated Hospital, College of Medicine, Zhejiang University,Hangzhou 310003, China

Corresponding email(s):   chenlihua-y@163.com

Key Words:  Antiphospholipid syndrome (APS), Antiphospholipid antibodies (APL), Thrombosis

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CHEN Li-hua, JIANG Ling-ling, LI You-ming, PENG Qing-bi. Antiphospholipid syndrome:a survey of clinical characters in ten cases[J]. Journal of Zhejiang University Science A, 2003, 4(5): 616-619.

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author="CHEN Li-hua, JIANG Ling-ling, LI You-ming, PENG Qing-bi",
journal="Journal of Zhejiang University Science A",
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%T Antiphospholipid syndrome:a survey of clinical characters in ten cases
%A CHEN Li-hua
%A JIANG Ling-ling
%A LI You-ming
%A PENG Qing-bi
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2003.0616

T1 - Antiphospholipid syndrome:a survey of clinical characters in ten cases
A1 - CHEN Li-hua
A1 - JIANG Ling-ling
A1 - LI You-ming
A1 - PENG Qing-bi
J0 - Journal of Zhejiang University Science A
VL - 4
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SP - 616
EP - 619
%@ 1869-1951
Y1 - 2003
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.2003.0616

Objective: To gain further understanding of the antiphospholipid syndrome (APS). Methods: Analysing clinical and laboratory data on ten cases of APS. Results: Thrombocytopenia appeared in all cases. Venous thrombi of limbs appeared in five cases and neurological abnormalities in two cases. Renal impairments were found in three cases. One case manifested left renal venous thrombi and the other two cases thrombotic microangiopathy. Budd-Chiari syndrome was found in one case. One of the ten cases was catastrophic APS (CAPS) presented as acute diffuse swelling, cyanosis, pain, ischemia and necrosis in fingers and limbs, recurrent shock, ascites, hepatic and respiratory dysfunction. Anticoagulants and corticosteroids could be effective for dealing with APS. It was critical to treat catastrophic APS with anticoagulants or plasmapheresis as early as possible. Conclusions: APS shows variable manifestations for good prognosis, but catastrophic APS has fatal risk. The main treatment for APS is the use of anticoagulants and immunosuppressives.

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