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Journal of Zhejiang University SCIENCE A 2004 Vol.5 No.2 P.235-241


Expression and significance of cyclin D1, p27kip1 protein in bronchioloalveolar carcinoma

Author(s):  YUAN Jian-qun, XU Jing-yao, ZHANG Jing, HE Qi-cai, ZHU Jia, SHENG Cai-xia

Affiliation(s):  Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China

Corresponding email(s):   yjq1971@hotmail.com

Key Words:  Adenocarcinoma, Bronchioloalveolar, Lung neoplasms, Cyclin D1, p27kip1, Immunohistochemistryction

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YUAN Jian-qun, XU Jing-yao, ZHANG Jing, HE Qi-cai, ZHU Jia, SHENG Cai-xia. Expression and significance of cyclin D1, p27kip1 protein in bronchioloalveolar carcinoma[J]. Journal of Zhejiang University Science A, 2004, 5(2): 235-241.

@article{title="Expression and significance of cyclin D1, p27kip1 protein in bronchioloalveolar carcinoma",
author="YUAN Jian-qun, XU Jing-yao, ZHANG Jing, HE Qi-cai, ZHU Jia, SHENG Cai-xia",
journal="Journal of Zhejiang University Science A",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Expression and significance of cyclin D1, p27kip1 protein in bronchioloalveolar carcinoma
%A YUAN Jian-qun
%A XU Jing-yao
%A HE Qi-cai
%A ZHU Jia
%A SHENG Cai-xia
%J Journal of Zhejiang University SCIENCE A
%V 5
%N 2
%P 235-241
%@ 1869-1951
%D 2004
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2004.0235

T1 - Expression and significance of cyclin D1, p27kip1 protein in bronchioloalveolar carcinoma
A1 - YUAN Jian-qun
A1 - XU Jing-yao
A1 - ZHANG Jing
A1 - HE Qi-cai
A1 - ZHU Jia
A1 - SHENG Cai-xia
J0 - Journal of Zhejiang University Science A
VL - 5
IS - 2
SP - 235
EP - 241
%@ 1869-1951
Y1 - 2004
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2004.0235

Purpose: To investigate the relationship between expression of cell cycle-related protein cyclin D1, p27kip1 and the pathogenesis of bronchioloalveolar carcinoma (BAC) and the value of prediction of prognosis. Methods: cyclin D1 and p27kip1 protein were detected by immunohistochemical En Vision method in 43 BACs. Results: The positivity of cyclin D1 in BAC was 65.1% (28/43), which was significantly higher than that in normal pulmonary tissue (0/13), P<0.01. No statistically significant association was found between cyclin D1 expression data and sex, age, tobacco-use history, histologic subtype (mucinous vs nonmucinous), stromal fibrosis, lymph node metastasis, clinical stage or postoperative survival period (P>0.05), while cyclin D1 expression was found to be negatively correlated with tumor size (P<0.05). The positivity of p27kip1 in BACs was 51.2% (22/43), significantly lower than that in normal pulmonary tissue (12/13), P<0.01. p27kip1 expression level was not associated with sex, age, tobacco-use history, tumor size or histologic subtype (P>0.05), but was negatively correlated with stromal fibrosis, lymph node metastasis and clinical stage (P<0.05); and positively associated with postoperative survival period (P<0.01). The survival rate of p27kip1 positive group was significantly higher than that of p27kip1 negative group (P<0.01). No statistically significant correlation was found between cyclin D1 and p27kip1 expression. Conclusions: Increased cyclin D1 expression and decreased p27kip1 expression are related to the pathogenesis of BAC; decreased p27kip1 expression is associated with metastasis progression; immunodetection of p27kip1 is useful for assessment of prognosis.

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