CLC number: R76
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Received: 2004-01-16
Revision Accepted: 2004-04-21
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TANG Jian-guo, LI Xuan, CHEN Ping. Expression of matrix metalloproteinase-9 in nasopharyngeal carcinoma and association with Epstein-Barr virus infection[J]. Journal of Zhejiang University Science A, 2004, 5(10): 1304-1312.
@article{title="Expression of matrix metalloproteinase-9 in nasopharyngeal carcinoma and association with Epstein-Barr virus infection",
author="TANG Jian-guo, LI Xuan, CHEN Ping",
journal="Journal of Zhejiang University Science A",
volume="5",
number="10",
pages="1304-1312",
year="2004",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2004.1304"
}
%0 Journal Article
%T Expression of matrix metalloproteinase-9 in nasopharyngeal carcinoma and association with Epstein-Barr virus infection
%A TANG Jian-guo
%A LI Xuan
%A CHEN Ping
%J Journal of Zhejiang University SCIENCE A
%V 5
%N 10
%P 1304-1312
%@ 1869-1951
%D 2004
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2004.1304
TY - JOUR
T1 - Expression of matrix metalloproteinase-9 in nasopharyngeal carcinoma and association with Epstein-Barr virus infection
A1 - TANG Jian-guo
A1 - LI Xuan
A1 - CHEN Ping
J0 - Journal of Zhejiang University Science A
VL - 5
IS - 10
SP - 1304
EP - 1312
%@ 1869-1951
Y1 - 2004
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2004.1304
Abstract: Objective: To evaluate the expression of matrix metalloproteinase-9 (MMP9) in nasopharyngeal carcinoma and the association between MMP9 and Epstein-Barr virus infection. Methods: The MMP9 expression was studied by immunohistochemical analysis; and Epstein-Barr virus encoded small nuclear mRNA-1 (EBER-1) produced by in situ hybridization were examined in 41 nasopharyngeal carcinoma sections, and the relation between them, and the associations of MMP9 with clinical features were statistically analyzed. Results: Positive expression rate of MMP9 was 73.17%. The expression of MMP9 showed significant positive correlation with the expression of EBER-1 (γ=0.483, P=0.001). There was significant association of MMP9 expression with lymph nodes metastasis and clinical stage (P<0.001), non-significant association with age, gender, pathological classification and T classification. Conclusions: The highly pronounced expression of MMP9 is associated with cervical lymph nodes metastasis. Epstein-Barr virus can enhance NPC metastasis by up-regulating the expression of MMP9.
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