CLC number: R97
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 0000-00-00
Cited: 10
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LU Ying-jun, ZHOU Jun, ZHANG Shao-min, ZHANG Heng-yi, ZHENG Xiao-xiang. Inhibitory effects of jujuboside A on EEG and hippocampal glutamate in hyperactive rat[J]. Journal of Zhejiang University Science B, 2005, 6(4): 265-271.
@article{title="Inhibitory effects of jujuboside A on EEG and hippocampal glutamate in hyperactive rat",
author="LU Ying-jun, ZHOU Jun, ZHANG Shao-min, ZHANG Heng-yi, ZHENG Xiao-xiang",
journal="Journal of Zhejiang University Science B",
volume="6",
number="4",
pages="265-271",
year="2005",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2005.B0265"
}
%0 Journal Article
%T Inhibitory effects of jujuboside A on EEG and hippocampal glutamate in hyperactive rat
%A LU Ying-jun
%A ZHOU Jun
%A ZHANG Shao-min
%A ZHANG Heng-yi
%A ZHENG Xiao-xiang
%J Journal of Zhejiang University SCIENCE B
%V 6
%N 4
%P 265-271
%@ 1673-1581
%D 2005
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2005.B0265
TY - JOUR
T1 - Inhibitory effects of jujuboside A on EEG and hippocampal glutamate in hyperactive rat
A1 - LU Ying-jun
A1 - ZHOU Jun
A1 - ZHANG Shao-min
A1 - ZHANG Heng-yi
A1 - ZHENG Xiao-xiang
J0 - Journal of Zhejiang University Science B
VL - 6
IS - 4
SP - 265
EP - 271
%@ 1673-1581
Y1 - 2005
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2005.B0265
Abstract: In this study, the inhibitory effect of jujuboside A (JuA) on a penicillin sodium (Na-PCN) induced hyperactivity model was investigated. Cortical EEG (electroencephalogram) and the concentration of hippocampal glutamate (Glu) were monitored simultaneously in vivo as indicators of rat’s excitatory state. power spectral density (PSD) and gravity frequency of PSD were calculated. JuA (0.05 g/L and 0.1 g/L) inhibited the EEG excitation effect caused by Na-PCN by increasing the power of δ1 and δ2 bands (P<0.01 vs model) and lowering the gravity frequency of PSD (P<0.01 vs model). JuA also remarkably reduced the Glu elevation induced by Na-PCN (P<0.05 vs model). diazepam also depressed Glu concentration and lowered the gravity frequency, but it showed a different EEG pattern in increased β2-activity (P<0.01 vs model). EEG excitation caused by Na-PCN correlated with Glu elevation during the first hour. Neurophysiological inhibitory effects of JuA and diazepam were more persistent than their Glu inhibitoty effects.
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