Full Text:   <2246>

CLC number: R719; R96

On-line Access: 

Received: 2006-04-25

Revision Accepted: 2006-07-20

Crosschecked: 0000-00-00

Cited: 6

Clicked: 4638

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
1. Reference List
Open peer comments

Journal of Zhejiang University SCIENCE B 2006 Vol.7 No.9 P.757-762


Effects of levobupivacaine and bupivacaine on rat myometrium

Author(s):  LI Zi-gang, ZHOU Liang, TANG Hui-fang

Affiliation(s):  Department of Anesthesiology, Women’ more

Corresponding email(s):   tanghuifang@zju.edu.cn

Key Words:  Levobupivacaine, Bupivacaine, Myometrium, Rat

LI Zi-gang, ZHOU Liang, TANG Hui-fang. Effects of levobupivacaine and bupivacaine on rat myometrium[J]. Journal of Zhejiang University Science B, 2006, 7(9): 757-762.

@article{title="Effects of levobupivacaine and bupivacaine on rat myometrium",
author="LI Zi-gang, ZHOU Liang, TANG Hui-fang",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Effects of levobupivacaine and bupivacaine on rat myometrium
%A LI Zi-gang
%A ZHOU Liang
%A TANG Hui-fang
%J Journal of Zhejiang University SCIENCE B
%V 7
%N 9
%P 757-762
%@ 1673-1581
%D 2006
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2006.B0757

T1 - Effects of levobupivacaine and bupivacaine on rat myometrium
A1 - LI Zi-gang
A1 - ZHOU Liang
A1 - TANG Hui-fang
J0 - Journal of Zhejiang University Science B
VL - 7
IS - 9
SP - 757
EP - 762
%@ 1673-1581
Y1 - 2006
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2006.B0757

Objective: To study the effect of bupivacaine%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>levobupivacaine and bupivacaine on the contractility of isolated uterine muscle strips from pregnant and non-pregnant female rats. Methods: Full-thick myometrial strips were prepared from 18- to 21-day pregnant (n=8) and non-pregnant rats (n=7). After contractions became regular, strips were exposed to cumulative concentrations of the two drugs from 10−8 to 10−4 mol/L, amplitude and frequency of the uterine contraction was recorded. Results: Two local anesthetics caused a concentration dependent inhibition on contractility of myometrial strips from pregnant and non-pregnant rats. In the myometrium from non-pregnant rats, −logIC50 of bupivacaine%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>levobupivacaine and bupivacaine were 4.85 and 4.25 respectively. In the myometrium from pregnant rats, similar concentrations of bupivacaine%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>levobupivacaine and bupivacaine were observed, −logIC50 were 2.7 and 2.9 respectively. bupivacaine%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>levobupivacaine produced an increase in amplitude of contractions, while bupivacaine showed an increased trend in frequency. Conclusion: These results demonstrate that bupivacaine%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>levobupivacaine and bupivacaine may inhibit myometrium contractility. The inhibitory effect of bupivacaine%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>levobupivacaine or bupivacaine is not enhanced by gestation in rat. bupivacaine%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>levobupivacaine may have more positive influence than bupivacaine in pregnant myometrium.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


[1] Alley, E.A., Kopacz, D.J., McDonald, S.B., Liu, S.S., 2002. Hyperbaric spinal levobupivacaine: a comparison to racemic bupivacaine in volunteers. Anesth. Analg., 94(1):188-193.

[2] Arici, G., Karsli, B., Kayacan, N., Akar, M., 2004. The effects of bupivacaine, ropivacaine and mepivacaine on the contractility of rat myometrium. Int. J. Obstet. Anesth., 13(2):95-98.

[3] Bardsley, H., Gristwood, R., Watson, N., Nimmo, W., 1997. The local anaesthetic activity of levobupivacaine does not differ from racemic bupivacaine (Marcain): first clinical evidence. Expert Opin. Investig. Drugs, 6(12):1883-1885.

[4] Branco, F.P., Ranali, J., Ambrosano, G.M., Volpato, M.C., 2006. A double-blind comparison of 0.5% bupivacaine with 1:200000 epinephrine and 0.5% levobupivacaine with 1:200000 epinephrine for the inferior alveolar nerve block. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 101(4):442-447.

[5] Bremerich, D.H., Zwissler, B., 2004. Levobupivacaine in obstetric analgesia and anaesthesia. Where is its place? Der Anaesthesist, 53(7):637-644.

[6] Capogna, G., Celleno, D., Lyons, G., Columb, M., Fusco, P., 1998. Minimum local analgesic concentration of extradural bupivacaine increases with progression of labour. Br. J. Anaesth., 80(1):11-13.

[7] Cheng, C.R., Su, T.H., Hung, Y.C., Wang, P.T., 2002. A comparative study of the safety and efficacy of 0.5% levobupivacaine and 0.5% bupivacaine for epidural anesthesia in subjects undergoing elective caesarean section. Acta Anaesthesiol. Sin., 40(1):13-20.

[8] Faccenda, K.A., Simpson, A.M., Henderson, D.J., Smith, D., McGrady, E.M., Morrison, L.M., 2003. A comparison of levobupivacaine 0.5% and racemic bupivacaine 0.5% for extradural anesthesia for caesarean section. Reg. Anesth. Pain Med., 28(5):394-400.

[9] Gautier, P., de Kock, M., Huberty, L., Demir, T., Izydorczic, M., Vanderick, B., 2003. Comparison of the effects of intrathecal ropivacaine, levobupivacaine, and bupivacaine for Caesarean section. Br. J. Anaesth., 91(5):684-689.

[10] Glaser, C., Marhofer, P., Zimpfer, G., Heinz, M.T., Sitzwohl, C., Kapral, S., Schindler, I., 2002. Levobupivacaine versus racemic bupivacaine for spinal anesthesia. Anesth. Analg., 94(1):194-198.

[11] Groen, K., Mantel, M., Zeijlmans, P.W., Zeppenfeldt, B., Olieman, W., Stienstra, R., van Kleef, J.W., Burm, A.G., 1998. Pharmacokinetics of the enantiomers of bupivacaine and mepivacaine after epidural administration of the racemates. Anesth. Analg., 86(2):361-366.

[12] Ivani, G., Borghi, B., van Oven, H., 2001. Levobupivacaine. Minerva. Anestesiol., 67(9 Suppl. 1):20-23.

[13] Karsli, B., Kayacan, N., Kucukyavuz, Z., Mimaroglu, C., 2003. Effects of local anesthetics on pregnant uterine muscles. Pol. J. Pharmacol., 55(1):51-56.

[14] Muguruma, T., Sakura, S., Kirihara, Y., Saito, Y., 2006. Comparative somatic and visceral antinociception and neurotoxicity of intrathecal bupivacaine, levobupivacaine, and dextrobupivacaine in rats. Anesthesiology, 104(6):1249-1256.

[15] Nielsen, P.E., Abouleish, E., Meyer, B.A., Parisi, V.M., 1996. Effect of epidural analgesia on fundal dominance during spontaneous active-phase nulliparous labor. Anesthesiology, 84(3):540-544.

[16] Oh, S.J., Paick, S.H., Lim, D.J., Lee, E., Lee, S.E., 2005. Effects of local anesthetics on human bladder contractility. Neurourol. Urodyn., 24(3):288-294.

[17] Palomaki, O., Huhtala, H., Kirkinen, P., 2005. A comparative study of the safety of 0.25% levobupivacaine and 0.25% racemic bupivacaine for paracervical block in the first stage of labor. Acta Obstet. Gynecol. Scand., 84(10):956-961.

[18] Santos, A.C., Arthur, G.R., Pedersen, H., Morishima, H.O., Finster, M., Covino, B.G., 1991. Systemic toxicity of ropivacaine during ovine pregnancy. Anesthesiology, 75(1):137-141.

[19] Santos, A.C., Arthur, G.R., Wlody, D., de Armas, P., Morishima, H.O., Finster, M., 1995. Comparative systemic toxicity of ropivacaine and bupivacaine in nonpregnant and pregnant ewes. Anesthesiology, 82(3):734-740.

[20] Scull, T.J., Hemmings, G.T., Carli, F., Weeks, S.K., Mazza, L., Zingg, H.H., 1998. Epidural analgesia in early labour blocks the stress response but uterine contractions remain unchanged. Can. J. Anesth., 45(7):626-630.

[21] Shibuya, N., Momose, Y., Ito, Y., 1993. Effects of bupivacaine on contraction and membrane potential in isolated canine papillary muscles. Pharmacology, 47(3):158-166.

[22] Strümper, D., Louwen, F., Durieux, M.E., Gramke, H.F., Stuessel, J., Marcus-Soekarman, D., van Aken, H., Marcus, M.A.E., 2005. Epidural local anesthetics: a novel treatment for fetal growth retardation? Fetal Diagn. Ther., 20(3):208-213.

[23] Vercauteren, M.P., Hans, G., de Decker, K., Adriaensen, H.A., 2001. Levobupivacaine combined with sufentanil and epinephrine for intrathecal labor analgesia: a comparison with racemic bupivacaine. Anesth. Analg., 93(4):996-1000.

[24] Wali, F.A., 1987. Local anaesthetics inhibit cholinergic and non-cholinergic neural and muscular contractions in avian tracheal smooth muscle. Acta Anaesthesiol. Scand., 31(2):148-153.

Open peer comments: Debate/Discuss/Question/Opinion


Please provide your name, email address and a comment

Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2023 Journal of Zhejiang University-SCIENCE