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Journal of Zhejiang University SCIENCE B 2005 Vol.6 No.6 P.508-513


Optimization of angiotensin I-converting enzyme (ACE) inhibition by rice dregs hydrolysates using response surface methodology

Author(s):  HE Guo-qing, XUAN Guo-dong, RUAN Hui, CHEN Qi-he, XU Ying

Affiliation(s):  Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310029, China

Corresponding email(s):   gqhe@zju.edu.cn

Key Words:  Angiotensin I-converting enzyme inhibitor, Rice dregs, Response surface methodology

HE Guo-qing, XUAN Guo-dong, RUAN Hui, CHEN Qi-he, XU Ying. Optimization of angiotensin I-converting enzyme (ACE) inhibition by rice dregs hydrolysates using response surface methodology[J]. Journal of Zhejiang University Science B, 2005, 6(6): 508-513.

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author="HE Guo-qing, XUAN Guo-dong, RUAN Hui, CHEN Qi-he, XU Ying",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Optimization of angiotensin I-converting enzyme (ACE) inhibition by rice dregs hydrolysates using response surface methodology
%A HE Guo-qing
%A XUAN Guo-dong
%A CHEN Qi-he
%A XU Ying
%J Journal of Zhejiang University SCIENCE B
%V 6
%N 6
%P 508-513
%@ 1673-1581
%D 2005
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2005.B0508

T1 - Optimization of angiotensin I-converting enzyme (ACE) inhibition by rice dregs hydrolysates using response surface methodology
A1 - HE Guo-qing
A1 - XUAN Guo-dong
A1 - RUAN Hui
A1 - CHEN Qi-he
A1 - XU Ying
J0 - Journal of Zhejiang University Science B
VL - 6
IS - 6
SP - 508
EP - 513
%@ 1673-1581
Y1 - 2005
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2005.B0508

Angiotensin I-converting enzyme (ACE) inhibitory peptides have been shown to have antihypertensive effects and have been utilized for physiologically functional foods and pharmaceuticals. The ACE inhibitory ability of a hydrolysate is determined by its peptide composition. However, the peptide composition of a hydrolysate depends on proteolytic enzyme and the hydrolysis conditions. In this study, the effect of process conditions on the ACE inhibitory activity of rice dregs hydrolyzed with a trypsin was investigated systematically using response surface methodology. It was shown that the ACE inhibitory activity of rice dregs hydrolysates could be controlled by regulation of five process conditions. Hydrolysis conditions for optimal ACE inhibition were defined using the response surface model of fractional factorial design (FFD), steepest ascent design, and central composite design (CCD).

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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Munkhjargal@Ass. prof in department of School of Chemistry and chemical engineering National university of Mongolia<monkhjargal@num.edu.mn>

2013-04-27 08:19:01

I am creating assay for ACE inhibitory of bioactive peptides from animal resaurces in our lab. So I am collecting information for this assay methods

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