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Received: 2005-06-30

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Journal of Zhejiang University SCIENCE B 2006 Vol.7 No.2 P.133-137

http://doi.org/10.1631/jzus.2006.B0133


Hemodynamic changes in depressive patients


Author(s):  Ma Ying, Li Hui-chun, Zheng Lei-lei, Yu Hua-liang

Affiliation(s):  Department of Psychiatry, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China

Corresponding email(s):   maying7211@sina.com

Key Words:  Depression, Anxiety, Heart function tests


Ma Ying, Li Hui-chun, Zheng Lei-lei, Yu Hua-liang. Hemodynamic changes in depressive patients[J]. Journal of Zhejiang University Science B, 2006, 7(2): 133-137.

@article{title="Hemodynamic changes in depressive patients",
author="Ma Ying, Li Hui-chun, Zheng Lei-lei, Yu Hua-liang",
journal="Journal of Zhejiang University Science B",
volume="7",
number="2",
pages="133-137",
year="2006",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2006.B0133"
}

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%T Hemodynamic changes in depressive patients
%A Ma Ying
%A Li Hui-chun
%A Zheng Lei-lei
%A Yu Hua-liang
%J Journal of Zhejiang University SCIENCE B
%V 7
%N 2
%P 133-137
%@ 1673-1581
%D 2006
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2006.B0133

TY - JOUR
T1 - Hemodynamic changes in depressive patients
A1 - Ma Ying
A1 - Li Hui-chun
A1 - Zheng Lei-lei
A1 - Yu Hua-liang
J0 - Journal of Zhejiang University Science B
VL - 7
IS - 2
SP - 133
EP - 137
%@ 1673-1581
Y1 - 2006
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2006.B0133


Abstract: 
Objective: This study is aimed at exploring the relationship between hemodynamic changes and depressive and anxious symptom in depression patients. Methods: The cardiac function indices including the left stroke index (LSI), ejection fraction (EF), heart rate (HR), diastolic pressure mean (DPM), systolic pressure mean (SPM), left ventricle end-diastolic volume (LVDV), effective circulating volume (ECV), resistance total mean (RTM) and blood flow smooth degree (BFSD) were determined in 65 patients with major depressive disorders and 31 healthy normal controls. The clinical symptoms were assessed with Hamilton depression scale (HAMD) and Hamilton anxiety scale (HAMA). Results: In patients with depression without anxiety, LSI, EF, LVDV, DPM, SPM, ECV, BFSD were significantly lower than those in controls, while RTM was higher than that in controls. Patients with comorbidity of depression and anxiety showed decreased LVDV, ECV, BFSD, and increased HR in comparison with the controls. The anxiety/somatization factor score positively correlated with LSI, EF, LVDV, but negatively correlated with RTM. There was negative correlation between retardation factor score and DPM, SPM, LVDV. Conclusion: The study indicated that there are noticeable changes in left ventricle preload and afterload, blood pressure, peripheral resistance, and microcirculation in depressive patients, and that the accompanying anxiety makes the changes more complicated.

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Reference

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