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Journal of Zhejiang University SCIENCE B 2006 Vol.7 No.9 P.738-744

http://doi.org/10.1631/jzus.2006.B0738


Dynamics of vascular volume and hemodilution of lactated Ringer’s solution in patients during induction of general and epidural anesthesia


Author(s):  LI Yu-hong, LOU Xian-feng, BAO Fang-ping

Affiliation(s):  Department of Anesthesiology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; more

Corresponding email(s):   yuh_li2002@hotmail.com

Key Words:  Hemodilution, Volume expansion, Ringer&rsquo, s solution, General anesthesia, Epidural anesthesia


LI Yu-hong, LOU Xian-feng, BAO Fang-ping. Dynamics of vascular volume and hemodilution of lactated Ringer’s solution in patients during induction of general and epidural anesthesia[J]. Journal of Zhejiang University Science B, 2006, 7(9): 738-744.

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author="LI Yu-hong, LOU Xian-feng, BAO Fang-ping",
journal="Journal of Zhejiang University Science B",
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pages="738-744",
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publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2006.B0738"
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%T Dynamics of vascular volume and hemodilution of lactated Ringer’s solution in patients during induction of general and epidural anesthesia
%A LI Yu-hong
%A LOU Xian-feng
%A BAO Fang-ping
%J Journal of Zhejiang University SCIENCE B
%V 7
%N 9
%P 738-744
%@ 1673-1581
%D 2006
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2006.B0738

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T1 - Dynamics of vascular volume and hemodilution of lactated Ringer’s solution in patients during induction of general and epidural anesthesia
A1 - LI Yu-hong
A1 - LOU Xian-feng
A1 - BAO Fang-ping
J0 - Journal of Zhejiang University Science B
VL - 7
IS - 9
SP - 738
EP - 744
%@ 1673-1581
Y1 - 2006
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2006.B0738


Abstract: 
Objective: To investigate the dynamics of vascular volume and the plasma dilution of lactated ringer&rsquo;s solution in patients during the induction of general and epidural anesthesia. Methods: The hemodilution of i.v. infusion of 1000 ml of lactated ringer&rsquo;s solution over 60 min was studied in patients undergoing general (n=31) and epidural (n=22) anesthesia. Heart rate, arterial blood pressure and hemoglobin (Hb) concentration were measured every 5 min during the study. Surgery was not started until the study period had been completed. Results: general anesthesia caused the greater decrease of mean arterial blood pressure (MAP) (mean 15% versus 9%; P<0.01) and thereby followed by a more pronounced plasma dilution, blood volume expansion (VE) and blood volume expansion efficiency (VEE). A strong linear correlation between hemodilution and the reduction in MAP (r=−0.50; P<0.01) was found. At the end of infusion, patients undergoing general anesthesia retained 47% (SD 19%) of the infused fluid in the circulation, while epidural anesthesia retained 29% (SD 13%) (P<0.001). Correspondingly, a fewer urine output (mean 89 ml versus 156 ml; P<0.05) and extravascular expansion (454 ml versus 551 ml; P<0.05) were found during general anesthesia. Conclusion: We concluded that the induction of general anesthesia caused more hemodilution, volume expansion and volume expansion efficiency than epidural anesthesia, which was triggered only by the lower MAP.

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