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CLC number: R614

On-line Access: 2017-11-06

Received: 2016-10-06

Revision Accepted: 2017-01-27

Crosschecked: 2017-10-20

Cited: 0

Clicked: 3383

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Min-qiang Liu

http://orcid.org/0000-0002-0048-2164

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Journal of Zhejiang University SCIENCE B 2017 Vol.18 No.11 P.955-962

http://doi.org/10.1631/jzus.B1600442


Administration of fentanyl via a slow intravenous fluid line compared with rapid bolus alleviates fentanyl-induced cough during general anesthesia induction


Author(s):  Min-qiang Liu, Feng-xian Li, Ya-kun Han, Jun-yong He, Hao-wen Shi, Li Liu, Ren-liang He

Affiliation(s):  Institute of Anesthesiology, Shenzhen Third People’s Hospital, Shenzhen 518112, China; more

Corresponding email(s):   szherenliang@163.com

Key Words:  General anesthesia, Fentanyl-induced cough, Slow intravenous fluid line, Alleviate, Induction


Min-qiang Liu, Feng-xian Li, Ya-kun Han, Jun-yong He, Hao-wen Shi, Li Liu, Ren-liang He. Administration of fentanyl via a slow intravenous fluid line compared with rapid bolus alleviates fentanyl-induced cough during general anesthesia induction[J]. Journal of Zhejiang University Science B, 2017, 18(11): 955-962.

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author="Min-qiang Liu, Feng-xian Li, Ya-kun Han, Jun-yong He, Hao-wen Shi, Li Liu, Ren-liang He",
journal="Journal of Zhejiang University Science B",
volume="18",
number="11",
pages="955-962",
year="2017",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1600442"
}

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%T Administration of fentanyl via a slow intravenous fluid line compared with rapid bolus alleviates fentanyl-induced cough during general anesthesia induction
%A Min-qiang Liu
%A Feng-xian Li
%A Ya-kun Han
%A Jun-yong He
%A Hao-wen Shi
%A Li Liu
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T1 - Administration of fentanyl via a slow intravenous fluid line compared with rapid bolus alleviates fentanyl-induced cough during general anesthesia induction
A1 - Min-qiang Liu
A1 - Feng-xian Li
A1 - Ya-kun Han
A1 - Jun-yong He
A1 - Hao-wen Shi
A1 - Li Liu
A1 - Ren-liang He
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SP - 955
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1600442


Abstract: 
Objective: fentanyl-induced cough (FIC) is a common complication with a reported incidence from 18.0% to 74.4% during general anesthesia induction. FIC increases the intrathoracic pressure and risks of postoperative nausea and vomiting, yet available treatments are limited. This study was designed to investigate whether administering fentanyl via a slow intravenous fluid line can effectively alleviate FIC during induction of total intravenous general anesthesia. Methods: A total number of 1200 patients, aged 18–64 years, were enrolled, all of whom were American Society of Anesthesiologists (ASA) grade I or II undergoing scheduled surgeries. All patients received total intravenous general anesthesia, which was induced sequentially by midazolam, fentanyl, propofol, and cisatracurium injection. Patients were randomly assigned to receive fentanyl 3.5 μg/kg via direct injection (control group) or via a slow intravenous fluid line. FIC incidence and the severity grades were analyzed with the Mann-Whitney test. Other adverse reactions, such as hypotension, hypertension, bradycardia, tachycardia, hypoxemia, vomiting, and aspiration, during induction were also observed. The online clinical registration number of this study was ChiCTR-IOR-16009025. Results: Compared with the control group, the incidence of FIC was significantly lower in the slow intravenous fluid line group during induction (9.1%, 95% confidence interval (CI):6.7%–11.4% vs. 55.9%, 95% CI: 51.8%–60.0%, P=0.000), as were the severity grades (P=0.000). There were no statistical differences between the two groups with regard to other adverse reactions (P>0.05). Conclusions: The administration of fentanyl via a slow intravenous fluid line can alleviate FIC and its severity during induction for total intravenous general anesthesia. This method is simple, safe, and reliable, and deserves clinical expansion.

全麻诱导期经静脉输液管缓慢滴注和快速输注芬太尼对该药诱发呛咳的影响

目的:探讨全麻诱导期经静脉输液管(墨菲氏管)给药能否减轻芬太尼诱发的呛咳。
创新点:寻找一个简单易行、安全可靠的方法减轻全麻诱导期芬太尼诱发的呛咳。与既往芬成尼和呛咳相关的研究相比,本研究试验组操作不仅简便、快速,而且无需额外使用其它药物或设备,不增加人力成本或病人经济负担。
方法:择期行全身麻醉手术1138例,所有患者均采用咪达唑仑-芬太尼-丙泊酚-顺式阿曲库铵-气管插管麻醉,随机分为静脉输液管缓慢滴注组(S组,573例)与经三通快速输注组(C组,565例),记录麻醉诱导期两组患者呛咳发生率及严重程度和其它不良反应发生情况。
结论:静脉输液管缓慢滴注组呛咳发生率及严重程度较快速输注组明显降低,其它不良反应发生率比较差异无统计学意义。全麻诱导期经静脉输液管缓慢滴注芬太尼可明显降低该药所致呛咳的发生率,且该法简单易行、安全可靠,值得推广。

关键词:全麻;芬太尼诱发呛咳;缓慢滴注;减轻;诱导

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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