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Journal of Zhejiang University SCIENCE B 2007 Vol.8 No.10 P.715-720


Lance-Adams syndrome: a report of two cases

Author(s):  ZHANG Yan-xing, LIU Jian-ren, JIANG biao, LIU Hui-qin, DING Mei-ping, SONG Shui-jiang, ZHANG Bao-rong, ZHANG Hong, XU Bin, CHEN Huai-hong, WANG Zhong-jin, HUANG Jian-zheng

Affiliation(s):  Department of Neurology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China; more

Corresponding email(s):   liujianren0571@hotmail.com

Key Words:  Lance-Adams syndrome, Chronic post-hypoxic myoclonus, Action myoclonus, Cerebellar ataxia, Single photon emission computed tomography, Positron emission tomography, Magnetic resonance spectroscopy

ZHANG Yan-xing, LIU Jian-ren, JIANG biao, LIU Hui-qin, DING Mei-ping, SONG Shui-jiang, ZHANG Bao-rong, ZHANG Hong, XU Bin, CHEN Huai-hong, WANG Zhong-jin, HUANG Jian-zheng. Lance-Adams syndrome: a report of two cases[J]. Journal of Zhejiang University Science B, 2007, 8(10): 715-720.

@article{title="Lance-Adams syndrome: a report of two cases",
author="ZHANG Yan-xing, LIU Jian-ren, JIANG biao, LIU Hui-qin, DING Mei-ping, SONG Shui-jiang, ZHANG Bao-rong, ZHANG Hong, XU Bin, CHEN Huai-hong, WANG Zhong-jin, HUANG Jian-zheng",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Lance-Adams syndrome: a report of two cases
%A ZHANG Yan-xing
%A LIU Jian-ren
%A JIANG biao
%A LIU Hui-qin
%A DING Mei-ping
%A SONG Shui-jiang
%A ZHANG Bao-rong
%A XU Bin
%A CHEN Huai-hong
%A WANG Zhong-jin
%A HUANG Jian-zheng
%J Journal of Zhejiang University SCIENCE B
%V 8
%N 10
%P 715-720
%@ 1673-1581
%D 2007
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2007.B0715

T1 - Lance-Adams syndrome: a report of two cases
A1 - ZHANG Yan-xing
A1 - LIU Jian-ren
A1 - JIANG biao
A1 - LIU Hui-qin
A1 - DING Mei-ping
A1 - SONG Shui-jiang
A1 - ZHANG Bao-rong
A1 - ZHANG Hong
A1 - XU Bin
A1 - CHEN Huai-hong
A1 - WANG Zhong-jin
A1 - HUANG Jian-zheng
J0 - Journal of Zhejiang University Science B
VL - 8
IS - 10
SP - 715
EP - 720
%@ 1673-1581
Y1 - 2007
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2007.B0715

chronic post-hypoxic myoclonus, also known as lance-Adams syndrome (LAS), is a rare complication of successful cardiopulmanry resuscitation often accompanied by action myoclonus and cerebellar ataxia. It is seen in patients who have undergone a cardiorespiratory arrest, regained consciousness afterwards, and then developed myoclonus days or weeks after the event. Worldwide, 122 cases have been reported in the literature so far, including 1 case of Chinese. Here we report 2 Chinese LAS patients with detailed neuroimagings. Cranial single photon emission computed tomography (SPECT) of patient 1, a 52-year-old woman, showed a mild hypoperfusion in her left temporal lobe, whereas patient 2, a 54-year-old woman, manifested a mild bilateral decrease of glucose metabolism in the frontal lobes and a mild to moderate decrease of the N-acetyl aspartate (NAA) peak in the bilateral hippocampi by cranial [18F]-fluorodeoxyglucose positron emission tomographic (PET) scan and cranial magnetic resonance spectroscopy (MRS), respectively. We also review the literature on the neuroimaging, pathogenesis, and treatment of LAS.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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