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Journal of Zhejiang University SCIENCE B 2008 Vol.9 No.11 P.871-878


Albumin resuscitation protects against traumatic/hemorrhagic shock-induced lung apoptosis in rats

Author(s):  Yun ZHANG, Zhong-yan LIANG, Shao-yang ZHANG, Fang-fang HUANG, Wei WU, Yuan GAO, Zuo-bing CHEN

Affiliation(s):  Department of Emergency Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; more

Corresponding email(s):   chenzuobing@hotmail.com

Key Words:  Traumatic/hemorrhagic shock (T/HS), Mitogen-activated protein kinase (MAPK), Nuclear factor &kappa, B (NF-&kappa, B), Albumin, Apoptosis

Yun ZHANG, Zhong-yan LIANG, Shao-yang ZHANG, Fang-fang HUANG, Wei WU, Yuan GAO, Zuo-bing CHEN. Albumin resuscitation protects against traumatic/hemorrhagic shock-induced lung apoptosis in rats[J]. Journal of Zhejiang University Science B, 2008, 9(11): 871-878.

@article{title="Albumin resuscitation protects against traumatic/hemorrhagic shock-induced lung apoptosis in rats",
author="Yun ZHANG, Zhong-yan LIANG, Shao-yang ZHANG, Fang-fang HUANG, Wei WU, Yuan GAO, Zuo-bing CHEN",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Albumin resuscitation protects against traumatic/hemorrhagic shock-induced lung apoptosis in rats
%A Zhong-yan LIANG
%A Shao-yang ZHANG
%A Fang-fang HUANG
%A Wei WU
%A Yuan GAO
%A Zuo-bing CHEN
%J Journal of Zhejiang University SCIENCE B
%V 9
%N 11
%P 871-878
%@ 1673-1581
%D 2008
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0820130

T1 - Albumin resuscitation protects against traumatic/hemorrhagic shock-induced lung apoptosis in rats
A1 - Yun ZHANG
A1 - Zhong-yan LIANG
A1 - Shao-yang ZHANG
A1 - Fang-fang HUANG
A1 - Wei WU
A1 - Yuan GAO
A1 - Zuo-bing CHEN
J0 - Journal of Zhejiang University Science B
VL - 9
IS - 11
SP - 871
EP - 878
%@ 1673-1581
Y1 - 2008
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0820130

Objective: To determine the effects of albumin administration on lung injury and apoptosis in traumatic/hemorrhagic shock (T/HS) rats. Methods: Studies were performed on an in vivo model of spontaneously breathing rats with induced T/HS; the rats were subjected to femur fracture, ischemia for 30 min, and reperfusion for 20 min with Ringer’s lactate solution (RS) or 5% (w/v) albumin (ALb), and the left lower lobes of the lungs were resected. Results: albumin administered during reperfusion markedly attenuated injury of the lung and decreased the concentration of lactic acid and the number of in situ TdT-mediated dUTP nick-end labelling (TUNEL)-positive cells. Moreover, immunohistochemistry performed 24 h after reperfusion revealed increases in the level of nuclear factor &kappa;b (NF-&kappa;b), and phosphorylated p38 mitogen-activated protein kinase (MAPK) in the albumin-untreated group was down-regulated by albumin treatment when compared with the sham rats. Conclusion: Resuscitation with albumin attenuates tissue injury and inhibits T/HS-induced apoptosis in the lung via the p38 MAPK signal transduction pathway that functions to stimulate the activation of NF-κB.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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