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Received: 2009-02-22

Revision Accepted: 2009-06-17

Crosschecked: 2009-07-08

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Journal of Zhejiang University SCIENCE B 2009 Vol.10 No.8 P.625-630


Influence of systemic immune and cytokine responses during the acute phase of zoster on the development of postherpetic neuralgia

Author(s):  Sheng-mei ZHU, Yong-min LIU, Er-dan AN, Qing-lian CHEN

Affiliation(s):  Department of Anesthesiology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; more

Corresponding email(s):   sx169y@163.com

Key Words:  T lymphocyte, Cytokines, Postherpetic neuralgia (PHN), Herpes zoster (HZ)

Sheng-mei ZHU, Yong-min LIU, Er-dan AN, Qing-lian CHEN. Influence of systemic immune and cytokine responses during the acute phase of zoster on the development of postherpetic neuralgia[J]. Journal of Zhejiang University Science B, 2009, 10(8): 625-630.

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author="Sheng-mei ZHU, Yong-min LIU, Er-dan AN, Qing-lian CHEN",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Influence of systemic immune and cytokine responses during the acute phase of zoster on the development of postherpetic neuralgia
%A Sheng-mei ZHU
%A Yong-min LIU
%A Er-dan AN
%A Qing-lian CHEN
%J Journal of Zhejiang University SCIENCE B
%V 10
%N 8
%P 625-630
%@ 1673-1581
%D 2009
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0920049

T1 - Influence of systemic immune and cytokine responses during the acute phase of zoster on the development of postherpetic neuralgia
A1 - Sheng-mei ZHU
A1 - Yong-min LIU
A1 - Er-dan AN
A1 - Qing-lian CHEN
J0 - Journal of Zhejiang University Science B
VL - 10
IS - 8
SP - 625
EP - 630
%@ 1673-1581
Y1 - 2009
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0920049

postherpetic neuralgia (PHN) is a severe sequela of herpes zoster (HZ). Until now, only age and pain severity were considered predisposing factors for the development of PHN. We evaluated 49 patients with acute phase HZ, 10 of whom developed PHN (Group A) and 39 of whom did not develop PHN (Group B). Twenty-five healthy volunteers similar in age and gender distribution to the study group were recruited as controls (Group C). Numbers of serum CD3+ (pan-t lymphocytes), CD4+ (helper/inducer), and CD8+ (suppressor/cytotoxic) lymphocytes were decreased significantly in Groups A and B relative to the control group, but there were no statistical differences between Groups A and B. Interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, IL-8, and IL-10 were significantly elevated in Groups A and B relative to Group C. IL-6 was significantly higher in Group A than in Group B, and was significantly positively correlated with pain severity scored on a visual analog scale. Therefore, we suggest that the inflammatory response, especially that of IL-6, in the acute phase of HZ may be associated with hyperalgesia and the development of PHN.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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