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Huashan YI


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Journal of Zhejiang University SCIENCE B 2021 Vol.22 No.8 P.609-632


Toll-like receptor 3 (TLR3) regulation mechanisms and roles in antiviral innate immune responses

Author(s):  Yujuan CHEN, Junhong LIN, Yao ZHAO, Xianping MA, Huashan YI

Affiliation(s):  College of Veterinary Medicine, Southwest University, Chongqing 402460, China; more

Corresponding email(s):   dyxyihuashan@swu.edu.cn

Key Words:  Toll-like receptor 3 (TLR3), Toll-interleukin-1 receptor (TIR)‍, -domain-containing adaptor-inducing interferon-‍, β, (TRIF), Innate immune, Antiviral response

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Yujuan CHEN, Junhong LIN, Yao ZHAO, Xianping MA, Huashan YI. Toll-like receptor 3 (TLR3) regulation mechanisms and roles in antiviral innate immune responses[J]. Journal of Zhejiang University Science B, 2021, 22(8): 609-632.

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author="Yujuan CHEN, Junhong LIN, Yao ZHAO, Xianping MA, Huashan YI",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%A Xianping MA
%A Huashan YI
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2000808

T1 - Toll-like receptor 3 (TLR3) regulation mechanisms and roles in antiviral innate immune responses
A1 - Yujuan CHEN
A1 - Junhong LIN
A1 - Yao ZHAO
A1 - Xianping MA
A1 - Huashan YI
J0 - Journal of Zhejiang University Science B
VL - 22
IS - 8
SP - 609
EP - 632
%@ 1673-1581
Y1 - 2021
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2000808

toll-like receptor 3 (TLR3) is a member of the TLR family, mediating the transcriptional induction of type I interferons (IFNs), proinflammatory cytokines, and chemokines, thereby collectively establishing an antiviral host response. Studies have shown that unlike other TLR family members, TLR3 is the only RNA sensor that is utterly dependent on the toll-interleukin-1 receptor (TIR)‍;-domain-containing adaptor-inducing IFN-‍β;(TRIF). However, the details of how the TLR3-TRIF signaling pathway works in an antiviral response and how it is regulated are unclear. In this review, we focus on recent advances in understanding the antiviral mechanism of the TRIF pathway and describe the essential characteristics of TLR3 and its antiviral effects. Advancing our understanding of TLR3 may contribute to disease diagnosis and could foster the development of novel treatments for viral diseases.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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