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Journal of Zhejiang University SCIENCE B 2010 Vol.11 No.3 P.151-168


Global nutrient profiling by Phenotype MicroArrays: a tool complementing genomic and proteomic studies in conidial fungi

Author(s):  Lea Atanasova, Irina S. Druzhinina

Affiliation(s):  Research Area of Gene Technology and Applied Biochemistry, Institute of Chemical Engineering, Vienna University of Technology, A-1060 Vienna, Austria

Corresponding email(s):   druzhini@mail.zserv.tuwien.ac.at

Key Words:  Biolog Phenotype MicroArray, Mitosporic fungi, Carbon metabolism, Trichoderma, Aspergillus, Biotechnology

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Lea Atanasova, Irina S. Druzhinina. Global nutrient profiling by Phenotype MicroArrays: a tool complementing genomic and proteomic studies in conidial fungi[J]. Journal of Zhejiang University Science B, 2010, 11(3): 151-168.

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author="Lea Atanasova, Irina S. Druzhinina",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Global nutrient profiling by Phenotype MicroArrays: a tool complementing genomic and proteomic studies in conidial fungi
%A Lea Atanasova
%A Irina S. Druzhinina
%J Journal of Zhejiang University SCIENCE B
%V 11
%N 3
%P 151-168
%@ 1673-1581
%D 2010
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1000007

T1 - Global nutrient profiling by Phenotype MicroArrays: a tool complementing genomic and proteomic studies in conidial fungi
A1 - Lea Atanasova
A1 - Irina S. Druzhinina
J0 - Journal of Zhejiang University Science B
VL - 11
IS - 3
SP - 151
EP - 168
%@ 1673-1581
Y1 - 2010
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1000007

Conidial fungi or molds and mildews are widely used in modern biotechnology as producers of antibiotics and other secondary metabolites, industrially important enzymes, chemicals and food. They are also important pathogens of animals including humans and agricultural crops. These various applications and extremely versatile natural phenotypes have led to the constantly growing list of complete genomes which are now available. Functional genomics and proteomics widely exploit the genomic information to study the cell-wide impact of altered genes on the phenotype of an organism and its function. This allows for global analysis of the information flow from DNA to RNA to protein, but it is usually not sufficient for the description of the global phenotype of an organism. More recently, Phenotype MicroArray (PM) technology has been introduced as a tool to characterize the metabolism of a (wild) fungal strain or a mutant. In this article, we review the background of PM applications for fungi and the methodic requirements to obtain reliable results. We also report examples of the versatility of this tool.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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Open peer comments: Debate/Discuss/Question/Opinion



2010-03-11 11:12:07

This review is very interesting. The tool "Phenotype MicroArrays" is a new and effective one.

Please provide your name, email address and a comment

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