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CLC number: R962; Q65

On-line Access: 2011-02-04

Received: 2010-03-30

Revision Accepted: 2010-09-01

Crosschecked: 2011-01-11

Cited: 10

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Journal of Zhejiang University SCIENCE B 2011 Vol.12 No.2 P.135-142


Evaluation of the hepatoprotective and antioxidant activities of Rubus parvifolius L.

Author(s):  Jie Gao, Cui-rong Sun, Jie-hong Yang, Jian-mei Shi, Yue-guang Du, Yu-yan Zhang, Jin-hui Li, Hai-tong Wan

Affiliation(s):  Department of Chemistry, Zhejiang University, Hangzhou 310027, China; more

Corresponding email(s):   suncuirong@zju.edu.cn, yannoo7376@sina.com

Key Words:  Rubus parvifolius L., High-performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS), Hepatoprotective activity, Antioxidant activity

Jie Gao, Cui-rong Sun, Jie-hong Yang, Jian-mei Shi, Yue-guang Du, Yu-yan Zhang, Jin-hui Li, Hai-tong Wan. Evaluation of the hepatoprotective and antioxidant activities of Rubus parvifolius L.[J]. Journal of Zhejiang University Science B, 2011, 12(2): 135-142.

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author="Jie Gao, Cui-rong Sun, Jie-hong Yang, Jian-mei Shi, Yue-guang Du, Yu-yan Zhang, Jin-hui Li, Hai-tong Wan",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%T Evaluation of the hepatoprotective and antioxidant activities of Rubus parvifolius L.
%A Jie Gao
%A Cui-rong Sun
%A Jie-hong Yang
%A Jian-mei Shi
%A Yue-guang Du
%A Yu-yan Zhang
%A Jin-hui Li
%A Hai-tong Wan
%J Journal of Zhejiang University SCIENCE B
%V 12
%N 2
%P 135-142
%@ 1673-1581
%D 2011
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1000117

T1 - Evaluation of the hepatoprotective and antioxidant activities of Rubus parvifolius L.
A1 - Jie Gao
A1 - Cui-rong Sun
A1 - Jie-hong Yang
A1 - Jian-mei Shi
A1 - Yue-guang Du
A1 - Yu-yan Zhang
A1 - Jin-hui Li
A1 - Hai-tong Wan
J0 - Journal of Zhejiang University Science B
VL - 12
IS - 2
SP - 135
EP - 142
%@ 1673-1581
Y1 - 2011
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1000117

The hepatoprotective and antioxidant activities of the n-butanol extract of Rubus parvifolius L. (RPL), a widely used medicinal plant, were evaluated. Results demonstrated that RPL extract possessed pronounced hepatoprotective effects against carbon tetrachloride (CCl4)-induced hepatic injury in mice, which was at least partially attributed to its strong antioxidant capacity. Treatment with RPL extract markedly attenuated the increases in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels caused by CCl4 intoxication. It also significantly prevented the decrease in superoxide dismutase (SOD) activity and the increase in malondialdehyde (MDA) content of liver tissue. Meanwhile, histopathological changes of hepatic damage were also remarkably ameliorated. Phytochemical analysis based on high-performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS) revealed the presence of various phenolic compounds, including caffeic acid conjugates, ellagic acid glycosides, and flavonol glycosides, which might be responsible for the hepatoprotective and antioxidant activities of RPL.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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