CLC number: R962; Q65
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2011-01-11
Cited: 10
Clicked: 5745
Jie Gao, Cui-rong Sun, Jie-hong Yang, Jian-mei Shi, Yue-guang Du, Yu-yan Zhang, Jin-hui Li, Hai-tong Wan. Evaluation of the hepatoprotective and antioxidant activities of Rubus parvifolius L.[J]. Journal of Zhejiang University Science B, 2011, 12(2): 135-142.
@article{title="Evaluation of the hepatoprotective and antioxidant activities of Rubus parvifolius L.",
author="Jie Gao, Cui-rong Sun, Jie-hong Yang, Jian-mei Shi, Yue-guang Du, Yu-yan Zhang, Jin-hui Li, Hai-tong Wan",
journal="Journal of Zhejiang University Science B",
volume="12",
number="2",
pages="135-142",
year="2011",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1000117"
}
%0 Journal Article
%T Evaluation of the hepatoprotective and antioxidant activities of Rubus parvifolius L.
%A Jie Gao
%A Cui-rong Sun
%A Jie-hong Yang
%A Jian-mei Shi
%A Yue-guang Du
%A Yu-yan Zhang
%A Jin-hui Li
%A Hai-tong Wan
%J Journal of Zhejiang University SCIENCE B
%V 12
%N 2
%P 135-142
%@ 1673-1581
%D 2011
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1000117
TY - JOUR
T1 - Evaluation of the hepatoprotective and antioxidant activities of Rubus parvifolius L.
A1 - Jie Gao
A1 - Cui-rong Sun
A1 - Jie-hong Yang
A1 - Jian-mei Shi
A1 - Yue-guang Du
A1 - Yu-yan Zhang
A1 - Jin-hui Li
A1 - Hai-tong Wan
J0 - Journal of Zhejiang University Science B
VL - 12
IS - 2
SP - 135
EP - 142
%@ 1673-1581
Y1 - 2011
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1000117
Abstract: The hepatoprotective and antioxidant activities of the n-butanol extract of Rubus parvifolius L. (RPL), a widely used medicinal plant, were evaluated. Results demonstrated that RPL extract possessed pronounced hepatoprotective effects against carbon tetrachloride (CCl4)-induced hepatic injury in mice, which was at least partially attributed to its strong antioxidant capacity. Treatment with RPL extract markedly attenuated the increases in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels caused by CCl4 intoxication. It also significantly prevented the decrease in superoxide dismutase (SOD) activity and the increase in malondialdehyde (MDA) content of liver tissue. Meanwhile, histopathological changes of hepatic damage were also remarkably ameliorated. Phytochemical analysis based on high-performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS) revealed the presence of various phenolic compounds, including caffeic acid conjugates, ellagic acid glycosides, and flavonol glycosides, which might be responsible for the hepatoprotective and antioxidant activities of RPL.
[1]Adnyana, I.K., Tezuka, Y., Banskota, A.H., Tran, K.Q., Kadota, S., 2001. Three new triterpenes from the seeds of Combretum quadrangulare and their hepatoprotective activity. J. Nat. Prod., 64(3):360-363.
[2]Carmona, M., Sánchez, A.M., Ferreres, F., Zalacain, A., Tomás-Barberán, F., Alonso, G.L., 2007. Identification of the flavonoid fraction in saffron spice by LC/DAD/MS/ MS: comparative study of samples from different geographical origins. Food Chem., 100(2):445-450.
[3]Chen, J.J., Li, X.Y., Sun, C.R., Pan, Y.J., Schlunegger, U.P., 2008. Identification of polyoxypregnane glycosides from the stems of Marsdenia tenacissima by high-performance liquid chromatography/tandem mass spectrometry. Talanta, 77(1):152-159.
[4]Compilation Group of Chinese Herbal Medicine Compilation, 1975. Chinese Herbal Medicine Compilation. People’s Medical Publishing House, Beijing, China, p.512 (in Chinese).
[5]Deighton, N., Brennan, R., Finn, C., Davies, H.V., 2000. Antioxidant properties of domesticated and wild Rubus species. J. Sci. Food Agric., 80(9):1307-1313.
[6]Fabre, N., Rustan, I., de Hoffmann, E., Quetin-Leclercq, J., 2001. Determination of flavone, flavonol, and flavanone aglycones by negative ion liquid chromatography electrospray ion trap mass spectrometry. J. Am. Soc. Mass Spectrom., 12(6):707-715.
[7]Ferreres, F., Sousa, C., Justin, M., Valentão, P., Andrade, P.B., Llorach, R., Rodrigues, A., Seabra, R.M., Leitão, A., 2005. Characterisation of the phenolic profile of Boerhaavia diffusa L. by HPLC-PAD-MS/MS as a tool for quality control. Phytochem. Anal., 16(6):451-458.
[8]Gowri Shankar, N.L., Manavalan, R., Venkappayya, D., David Raj, C., 2008. Hepatoprotective and antioxidant effects of Commiphora berryi (Arn) Engl bark extract against CCl4-induced oxidative damage in rats. Food Chem. Toxicol., 46(9):3182-3185.
[9]He, S., Wu, B., Pan, Y.J., Jiang, L.Y., 2008. Stilbene oligomers from Parthenocissus laetevirens: isolation, biomimetic synthesis, absolute configuration, and implication of antioxidative defense system in the plant. J. Org. Chem., 73(14):5233-5241.
[10]Hollecker, L., Pinna, M., Filippino, G., Scrugli, S., Pinna, B., Argiolas, F., Murru, M., 2009. Simultaneous determination of polyphenolic compounds in red and white grapes grown in Sardinia by high performance liquid chromatography-electron spray ionisation-mass spectrometry. J. Chromatogr. A, 1216(15):3402-3408.
[11]Hsiao, G., Shen, M.Y., Lin, K.H., Lan, M.H., Wu, L.Y., Chou, D.S., Lin, C.H., Su, C.H., Sheu, J.R., 2003. Antioxidative and hepatoprotective effects of Antrodia camphorata extract. J. Agric. Food Chem., 51(11):3302-3308.
[12]Huang, B., Ban, X.Q., He, J.S., Tong, J., Tian, J., Wang, Y.W., 2010. Hepatoprotective and antioxidant activity of ethanolic extracts of edible lotus (Nelumbo nucifera Gaertn.) leaves. Food Chem., 120(3):873-878.
[13]Huang, X., Liu, Y., Song, F.R., Liu, Z.Q., Liu, S.Y., 2009. Studies on principal components and antioxidant activity of different Radix Astragali samples using high-performance liquid chromatography/electrospray ionization multiple-stage tandem mass spectrometry. Talanta, 78(3):1090-1101.
[14]Hvattum, E., Ekeberg, D., 2003. Study of the collision-induced radical cleavage of flavonoid glycosides using negative electrospray ionization tandem quadrupole mass spectrometry. J. Mass Spectrom., 38(1):43-49.
[15]Jain, A., Soni, M., Deb, L., Jain, A., Rout, S.P., Gupta, V.B., Krishna, K.L., 2008. Antioxidant and hepatoprotective activity of ethanolic and aqueous extracts of Momordica dioica Roxb. leaves. J. Ethnopharmacol., 115(1):61-66.
[16]Jin, Y.S., Sa, J.H., Shim, T.H., Rhee, H.I., Wang, M.H., 2005. Hepatoprotective and antioxidant effects of Morus bombycis Koidzumi on CCl4-induced liver damage. Biochem. Biophys. Res. Commun., 329(3):991-995.
[17]Lee, D., Kang, S.J., Lee, S.H., Ro, J., Lee, K., Kinghorn, A.D., 2000. Phenolic compounds from the leaves of Cornus controversa. Phytochemistry, 53(3):405-407.
[18]Lee, J.H., Johnson, J.V., Talcott, S.T., 2005. Identification of ellagic acid conjugates and other polyphenolics in muscadine grapes by HPLC-ESI-MS. J. Agric. Food Chem., 53(15):6003-6010.
[19]Luo, X.D., Basile, M.J., Kennelly, E.J., 2002. Polyphenolic antioxidants from the fruits of Chrysophyllum cainito L. (Star Apple). J. Agric. Food Chem., 50(6):1379-1382.
[20]Ming, D.S., Jiang, R.W., But, P.P.H., Towers, G.H.N., Yu, D.Q., 2002. A new compound from Geum Rivale L. J. Asian Nat. Prod. Res., 4(3):217-220.
[21]Moco, S., Bino, R.J., Vorst, O., Verhoeven, H.A., de Groot, J., van Beek, T.A., Vervoort, J., de Vos, C.H.R., 2006. A liquid chromatography-mass spectrometry-based metabolome database for tomato. Plant Physiol., 141(4):1205-1218.
[22]Mullen, W., Yokota, T., Lean, M.E.J., Crozier, A., 2003. Analysis of ellagitannins and conjugates of ellagic acid and quercetin in raspberry fruits by LC-MSn. Phytochemistry, 64(2):617-624.
[23]Oh, H., Kim, D.H., Cho, J.H., Kim, Y.C., 2004. Hepatoprotective and free radical scavenging activities of phenolic petrosins and flavonoids isolated from Equisetum arvense. J. Ethnopharmacol., 95(2-3):421-424.
[24]Parveen, I., Winters, A., Threadgill, M.D., Hauck, B., Morris, P., 2008. Extraction, structural characterisation and evaluation of hydroxycinnamate esters of orchard grass (Dactylis glomerata) as substrates for polyphenol oxidase. Phytochemistry, 69(16):2799-2806.
[25]Ranawat, L., Bhatt, J., Patel, J., 2010. Hepatoprotective activity of ethanolic extracts of bark of Zanthoxylum armatum DC in CCl4 induced hepatic damage in rats. J. Ethnopharmacol., 127(3):777-780.
[26]Shyur, L.F., Tsung, J.H., Chen, J.H., Chiu, C.Y., Lo, C.P., 2005. Antioxidant properties of extracts from medicinal plants popularly used in Taiwan. Int. J. Appl. Sci. Eng., 3(3):195-202.
[27]Wang, Y., He, J.M., Chen, H., Zhang, D.S., Cai, H., Shao, H.B., 2006. Analysis of flavones in Rubus parvifolius Linn by high performance liquid chromatography combined with electrospray ionization-mass spectrometry and thin-layer chromatography combined with Fourier transform surface enhanced Raman spectroscopy. Chin. J. Anal. Chem., 34(8):1073-1077.
[28]Wu, Y.H., Yang, L.X., Wang, F., Wu, X.M., Zhou, C.X., Shi, S.Y., Mo, J.X., Zhao, Y., 2007. Hepatoprotective and antioxidative effects of total phenolics from Laggera pterodonta on chemical-induced injury in primary cultured neonatal rat hepatocytes. Food Chem. Toxicol., 45(8):1349-1355.
[29]Zafrilla, P., Ferreres, F., Tomás-Barberán, F.A., 2001. Effect of processing and storage on the antioxidant ellagic acid derivatives and flavonoids of red raspberry (Rubus idaeus) jams. J. Agric. Food Chem., 49(8):3651-3655.
[30]Zeashan, H., Amresh, G., Singh, S., Rao, C.V., 2009. Hepatoprotective and antioxidant activity of Amaranthus spinosus against CCl4 induced toxicity. J. Ethnopharmacol., 125(2):364-366.
Open peer comments: Debate/Discuss/Question/Opinion
<1>