CLC number: Q946.84
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2018-02-10
Cited: 0
Clicked: 6670
Le Ying, De-dong Kong, Yuan-yuan Gao, Feng Yan, Yue-fei Wang, Ping Xu. In vitro antioxidant activity of phenolic-enriched extracts from Zhangping Narcissus tea cake and their inhibition on growth and metastatic capacity of 4T1 murine breast cancer cells[J]. Journal of Zhejiang University Science B, 2018, 19(3): 199-210.
@article{title="In vitro antioxidant activity of phenolic-enriched extracts from Zhangping Narcissus tea cake and their inhibition on growth and metastatic capacity of 4T1 murine breast cancer cells",
author="Le Ying, De-dong Kong, Yuan-yuan Gao, Feng Yan, Yue-fei Wang, Ping Xu",
journal="Journal of Zhejiang University Science B",
volume="19",
number="3",
pages="199-210",
year="2018",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1700162"
}
%0 Journal Article
%T In vitro antioxidant activity of phenolic-enriched extracts from Zhangping Narcissus tea cake and their inhibition on growth and metastatic capacity of 4T1 murine breast cancer cells
%A Le Ying
%A De-dong Kong
%A Yuan-yuan Gao
%A Feng Yan
%A Yue-fei Wang
%A Ping Xu
%J Journal of Zhejiang University SCIENCE B
%V 19
%N 3
%P 199-210
%@ 1673-1581
%D 2018
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1700162
TY - JOUR
T1 - In vitro antioxidant activity of phenolic-enriched extracts from Zhangping Narcissus tea cake and their inhibition on growth and metastatic capacity of 4T1 murine breast cancer cells
A1 - Le Ying
A1 - De-dong Kong
A1 - Yuan-yuan Gao
A1 - Feng Yan
A1 - Yue-fei Wang
A1 - Ping Xu
J0 - Journal of Zhejiang University Science B
VL - 19
IS - 3
SP - 199
EP - 210
%@ 1673-1581
Y1 - 2018
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1700162
Abstract: Phenolics, as the main bioactive compounds in tea, have been suggested to have potential in the prevention of various human diseases. However, little is known about phenolics and their bioactivity in Zhangping Narcissue tea cake which is considered the most special kind of oolong tea. To unveil its bioactivity, three phenolic-enriched extracts were obtained from Zhangping Narcissue tea cake using ethyl acetate, n-butanol, and water. Their main chemical compositions and in vitro bioactivity were analyzed by high-performance liquid chromatography (HPLC) and ultra-performance liquid chromatography-mass spectrometry (UPLC-MS). The ethyl acetate fraction (ZEF) consisted of higher content of phenolics, flavonoids, procyanidins, and catechin monomers (including epigallocatechin gallate (EGCG), epicatechin gallate (ECG), and gallocatechin gallate (GCG)) than n-butanol fraction (ZBF) and water fraction (ZWF). ZEF exhibited the strongest antioxidant capacity in vitro due to its abundant bioactive compounds. This was validated by Pearson correlation and hierarchical clustering analyses. ZEF also showed a remarkable inhibition on the growth, migration, and invasion of 4T1 murine breast cancer cells.
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[35]List of electronic supplementary materials
[36]Fig. S1 Flow chart of phenolic-enriched extracts from Zhangping Narcissus tea cake
[37]Fig. S2 UPLC-MS chromatograms of ZBF
[38]Fig. S3 UPLC-MS chromatograms of ZEF
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