CLC number: Q987
On-line Access: 2011-06-07
Received: 2010-07-26
Revision Accepted: 2010-12-27
Crosschecked: 2011-04-27
Cited: 5
Clicked: 5097
Li Shi, Xiao-qin Huang, Lei Shi, Yu-fen Tao, Yu-feng Yao, Liang Yu, Ke-qin Lin, Wen Yi, Hao Sun, Katsushi Tokunaga, Jia-you Chu. HLA polymorphism of the Zhuang population reflects the common HLA characteristics among Zhuang-Dong language-speaking populations[J]. Journal of Zhejiang University Science B, 2011, 12(6): 428-435.
@article{title="HLA polymorphism of the Zhuang population reflects the common HLA characteristics among Zhuang-Dong language-speaking populations",
author="Li Shi, Xiao-qin Huang, Lei Shi, Yu-fen Tao, Yu-feng Yao, Liang Yu, Ke-qin Lin, Wen Yi, Hao Sun, Katsushi Tokunaga, Jia-you Chu",
journal="Journal of Zhejiang University Science B",
volume="12",
number="6",
pages="428-435",
year="2011",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1000285"
}
%0 Journal Article
%T HLA polymorphism of the Zhuang population reflects the common HLA characteristics among Zhuang-Dong language-speaking populations
%A Li Shi
%A Xiao-qin Huang
%A Lei Shi
%A Yu-fen Tao
%A Yu-feng Yao
%A Liang Yu
%A Ke-qin Lin
%A Wen Yi
%A Hao Sun
%A Katsushi Tokunaga
%A Jia-you Chu
%J Journal of Zhejiang University SCIENCE B
%V 12
%N 6
%P 428-435
%@ 1673-1581
%D 2011
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1000285
TY - JOUR
T1 - HLA polymorphism of the Zhuang population reflects the common HLA characteristics among Zhuang-Dong language-speaking populations
A1 - Li Shi
A1 - Xiao-qin Huang
A1 - Lei Shi
A1 - Yu-fen Tao
A1 - Yu-feng Yao
A1 - Liang Yu
A1 - Ke-qin Lin
A1 - Wen Yi
A1 - Hao Sun
A1 - Katsushi Tokunaga
A1 - Jia-you Chu
J0 - Journal of Zhejiang University Science B
VL - 12
IS - 6
SP - 428
EP - 435
%@ 1673-1581
Y1 - 2011
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1000285
Abstract: A study of the human leukocyte antigen (HLA) genetic characteristics in the Zhuang, the largest ethnic population in China, would provide insight into Zhuang history and give a useful tool for disease associations, transplantation, and anthropology. In the present study, we report the comprehensive HLA-A, HLA-B, HLA-C, and HLA-DRB1 alleles and haplotypes in the zhuang population of southern China for the first time. A total of 13 HLA-A, 24 HLA-B, 22 HLA-C, and 18 HLA-DRB1 were identified in 104 Zhuang individuals. The frequencies of HLA-A*11:01, A*02:07, A*24:02, A*02:03, and A*33:03 on A loci, B*15:02, B*58:01, B*46:01, and B*13:01 on B loci, C*03:04, C*08:01, C*01:02, C*03:02, and C*07:02 on C loci, and DRB1*15:01, DRB1*16:02, DRB1*14:01, DRB1*15:02, and DRB1*03:01 on the DRB1 loci were >10%. The A*33:03-C*03:02-B*58:01-DRB1*03:01 and A*02:07-C*01:02-B*46:01-DRB1*14:01 haplotypes were predominant in the Zhuang. The phylogenetic tree, as well as the analysis of haplotypes, suggested that the Zhuang are genetically similar to southern Chinese populations, especially the Zhuang-Dong language-speaking populations, such as the Bouyei, Dai, and Maonan. Even though the Zhuang and southern Chinese populations shared common alleles and haplotypes, the Zhuang has maintained its unique genetic characteristics.
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