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CLC number: R732.2

On-line Access: 2011-08-02

Received: 2011-06-21

Revision Accepted: 2011-07-06

Crosschecked: 2011-06-21

Cited: 32

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Journal of Zhejiang University SCIENCE B 2011 Vol.12 No.8 P.624-628


Complex pathologies of angiotensin II-induced abdominal aortic aneurysms

Author(s):  Alan Daugherty, Lisa A. Cassis, Hong Lu

Affiliation(s):  Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536-0509, USA, Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40536-0200, USA

Corresponding email(s):   Alan.Daugherty@uky.edu

Key Words:  Abdominal aortic aneurysms, Angiotensin II, Pathologies, Mouse

Alan Daugherty, Lisa A. Cassis, Hong Lu. Complex pathologies of angiotensin II-induced abdominal aortic aneurysms[J]. Journal of Zhejiang University Science B, 2011, 12(8): 624-628.

@article{title="Complex pathologies of angiotensin II-induced abdominal aortic aneurysms",
author="Alan Daugherty, Lisa A. Cassis, Hong Lu",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Complex pathologies of angiotensin II-induced abdominal aortic aneurysms
%A Alan Daugherty
%A Lisa A. Cassis
%A Hong Lu
%J Journal of Zhejiang University SCIENCE B
%V 12
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%P 624-628
%@ 1673-1581
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1101002

T1 - Complex pathologies of angiotensin II-induced abdominal aortic aneurysms
A1 - Alan Daugherty
A1 - Lisa A. Cassis
A1 - Hong Lu
J0 - Journal of Zhejiang University Science B
VL - 12
IS - 8
SP - 624
EP - 628
%@ 1673-1581
Y1 - 2011
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1101002

angiotensin II (AngII) is the primary bioactive peptide of the renin angiotensin system that plays a critical role in many cardiovascular diseases. Subcutaneous infusion of AngII into mice induces the development of abdominal aortic aneurysms (AAAs). Like human AAAs, AngII-induced AAA tissues exhibit progressive changes and considerable heterogeneity. This complex pathology provides an impediment to the quantification of aneurysmal tissue composition by biochemical and immunostaining techniques. Therefore, while the mouse model of AngII-induced AAAs provides a salutary approach to studying the mechanisms of the evolution of AAAs in humans, meaningful interpretation of mechanisms requires consideration of the heterogeneous nature of the diseased tissue.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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