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CLC number: R96

On-line Access: 2012-12-07

Received: 2012-10-20

Revision Accepted: 2012-10-22

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Journal of Zhejiang University SCIENCE B 2012 Vol.13 No.12 P.1029-1030

http://doi.org/10.1631/jzus.B1200288


Artesunate and its emerging anti-neoplastic effects: beyond its role in attenuating tumor growth in osteosarcomas


Author(s):  Shailendra Kapoor

Affiliation(s):  75 Crossing Place, Mechanicsville, VA 23223, USA

Corresponding email(s):   shailendrakapoor@yahoo.com

Key Words:  Artesunate, Apoptosis, HOS cell, Osteosarcomas


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Shailendra Kapoor. Artesunate and its emerging anti-neoplastic effects: beyond its role in attenuating tumor growth in osteosarcomas[J]. Journal of Zhejiang University Science B, 2012, 13(12): 1029-1030.

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Abstract: 
I read with great interest the recent article artesunate inhibits growth and induces apoptosis in human osteosarcoma HOS cell line in vitro and in vivo” by Xu et al. (2011), published in Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology). artesunate exerts anti-neoplastic effects in a number of systemic malignancies besides osteosarcomas.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]Hamacher-Brady, A., Stein, H.A., Turschner, S., Toegel, I., Mora, R., Jennewein, N., Efferth, T., Eils, R., Brady, N.R., 2011. Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production. J. Biol. Chem., 286(8):6587-6601.

[2]Jiang, Z., Chai, J., Chuang, H.H., Li, S., Wang, T., Cheng, Y., Chen, W., Zhou, D., 2012. Artesunate induces G0/G1 cell cycle arrest and iron-mediated mitochondrial apoptosis in A431 human epidermoid carcinoma cells. Anticancer Drugs, 23(6):606-613.

[3]Ma, H., Yao, Q., Zhang, A.M., Lin, S., Wang, X.X., Wu, L., Sun, J.G., Chen, Z.T., 2011. The effects of artesunate on the expression of EGFR and ABCG2 in A549 human lung cancer cells and a xenograft model. Molecules, 16(12):10556-10569.

[4]Rasheed, S.A., Efferth, T., Asangani, I.A., Allgayer, H., 2010. First evidence that the antimalarial drug artesunate inhibits invasion and in vivo metastasis in lung cancer by targeting essential extracellular proteases. Int. J. Cancer, 127(6):1475-1485.

[5]Reichert, S., Reinboldt, V., Hehlgans, S., Efferth, T., Rodel, C., Rodel, F., 2012. A radiosensitizing effect of artesunate in glioblastoma cells is associated with a diminished expression of the inhibitor of apoptosis protein survivin. Radiother. Oncol., 103(3):394-401.

[6]Thanaketpaisarn, O., Waiwut, P., Sakurai, H., Saiki, I., 2011. Artesunate enhances TRAIL-induced apoptosis in human cervical carcinoma cells through inhibition of the NF-kappaB and PI3K/Akt signaling pathways. Int. J. Oncol., 39(1):279-285.

[7]Xu, Q., Li, Z.X., Peng, H.Q., Sun, Z.W., Cheng, R.L., Ye, Z.M., Li, W.X., 2011. Artesunate inhibits growth and induces apoptosis in human osteosarcoma HOS cell line in vitro and in vivo. J. Zhejiang Univ.-Sci. B (Biomed. & Biotechnol.), 12(4):247-255.

[8]Zhao, Y., Jiang, W., Li, B., Yao, Q., Dong, J., Cen, Y., Pan, X., Li, J., Zheng, J., Pang, X., et al., 2011. Artesunate enhances radiosensitivity of human non-small cell lung cancer A549 cells via increasing no production to induce cell cycle arrest at G2/M phase. Int. Immunopharmacol., 11(12):2039-2046.

[9]Zhou, C., Pan, W., Wang, X.P., Chen, T.S., 2012. Artesunate induces apoptosis via a bak-mediated caspase-independent intrinsic pathway in human lung adenocarcinoma cells. J. Cell Physiol., 227(12):3778-3786.

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