CLC number: R780.1
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2014-02-11
Cited: 3
Clicked: 8379
Shu-fan Zhao, Mao-zhou Chai, Min Wu, Yong-hong He, Tian Meng, Bing Shi. Effect of vitamin B12 on cleft palate induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin and dexamethasone in mice[J]. Journal of Zhejiang University Science B, 2014, 15(3): 289-294.
@article{title="Effect of vitamin B12 on cleft palate induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin and dexamethasone in mice",
author="Shu-fan Zhao, Mao-zhou Chai, Min Wu, Yong-hong He, Tian Meng, Bing Shi",
journal="Journal of Zhejiang University Science B",
volume="15",
number="3",
pages="289-294",
year="2014",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1300083"
}
%0 Journal Article
%T Effect of vitamin B12 on cleft palate induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin and dexamethasone in mice
%A Shu-fan Zhao
%A Mao-zhou Chai
%A Min Wu
%A Yong-hong He
%A Tian Meng
%A Bing Shi
%J Journal of Zhejiang University SCIENCE B
%V 15
%N 3
%P 289-294
%@ 1673-1581
%D 2014
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1300083
TY - JOUR
T1 - Effect of vitamin B12 on cleft palate induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin and dexamethasone in mice
A1 - Shu-fan Zhao
A1 - Mao-zhou Chai
A1 - Min Wu
A1 - Yong-hong He
A1 - Tian Meng
A1 - Bing Shi
J0 - Journal of Zhejiang University Science B
VL - 15
IS - 3
SP - 289
EP - 294
%@ 1673-1581
Y1 - 2014
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1300083
Abstract: The purpose of this study was to investigate the effect of 28vitamin B12%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>vitamin B12 on palatal development by co-administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and dexamethasone (DEX). We examined the morphological and histological features of the palatal shelf and expression levels of key signaling molecules (28transforming growth factor-&beta%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>transforming growth factor-β283 (TGF-&beta%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>3 (TGF-β283)%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>3) and TGF-β type I receptor (activin receptor-like kinase 5, ALK5)) during palatogenesis among a control group (Group A), TCDD+DEX exposed group (Group B), and TCDD+DEX+28vitamin B12%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>vitamin B12 exposed group (Group C). While we failed to find that 28vitamin B12%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>vitamin B12 decreased the incidence of 28cleft palate%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>cleft palate induced by TCDD+DEX treatment, the expression levels of key signaling molecules (TGF-β3 and ALK5) during palatogenesis were significantly modulated. In TCDD+DEX exposed and TCDD+DEX+28vitamin B12%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>vitamin B12 exposed groups, palatal shelves could not contact in the midline due to their small sizes. Our results suggest that 28vitamin B12%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>vitamin B12 may inhibit the expression of some 28cleft palate%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>cleft palate inducers such as TGF-β3 and ALK5 in DEX+TCDD exposed mice, which may be beneficial against palatogenesis to some degree, even though we were unable to observe a protective role of 28vitamin B12%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>vitamin B12 in morphological and histological alterations of palatal shelves induced by DEX and TCDD.
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