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Journal of Zhejiang University SCIENCE B 2013 Vol.14 No.12 P.1059-1069


Induced pluripotent stem cells: origins, applications, and future perspectives

Author(s):  Jing Zhao, Wen-jie Jiang, Chen Sun, Cong-zhe Hou, Xiao-mei Yang, Jian-gang Gao

Affiliation(s):  School of Life Sciences, Shandong University, Jinan 250100, China

Corresponding email(s):   yxm411@sdu.edu.cn, jggao@sdu.edu.cn

Key Words:  Induced pluripotent stem cells, Origin, Peripheral blood cells, Application, Potential issues

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Jing Zhao, Wen-jie Jiang, Chen Sun, Cong-zhe Hou, Xiao-mei Yang, Jian-gang Gao. Induced pluripotent stem cells: origins, applications, and future perspectives[J]. Journal of Zhejiang University Science B, 2013, 14(12): 1059-1069.

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author="Jing Zhao, Wen-jie Jiang, Chen Sun, Cong-zhe Hou, Xiao-mei Yang, Jian-gang Gao",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Induced pluripotent stem cells: origins, applications, and future perspectives
%A Jing Zhao
%A Wen-jie Jiang
%A Chen Sun
%A Cong-zhe Hou
%A Xiao-mei Yang
%A Jian-gang Gao
%J Journal of Zhejiang University SCIENCE B
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%N 12
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%D 2013
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1300215

T1 - Induced pluripotent stem cells: origins, applications, and future perspectives
A1 - Jing Zhao
A1 - Wen-jie Jiang
A1 - Chen Sun
A1 - Cong-zhe Hou
A1 - Xiao-mei Yang
A1 - Jian-gang Gao
J0 - Journal of Zhejiang University Science B
VL - 14
IS - 12
SP - 1059
EP - 1069
%@ 1673-1581
Y1 - 2013
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1300215

Embryonic stem (ES) cells are widely used for different purposes, including gene targeting, cell therapy, tissue repair, organ regeneration, and so on. However, studies and applications of ES cells are hindered by ethical issues regarding cell sources. To circumvent ethical disputes, great efforts have been taken to generate ES cell-like cells, which are not derived from the inner cell mass of blastocyst-stage embryos. In 2006, Yamanaka et al. first reprogrammed mouse embryonic fibroblasts into ES cell-like cells called induced pluripotent stem (iPS) cells. About one year later, Yamanaka et al. and Thomson et al. independently reprogrammed human somatic cells into iPS cells. Since the first generation of iPS cells, they have now been derived from quite a few different kinds of cell types. In particular, the use of peripheral blood facilitates research on iPS cells because of safety, easy availability, and plenty of cell sources. Now iPS cells have been used for cell therapy, disease modeling, and drug discovery. In this review, we describe the generations, applications, potential issues, and future perspectives of iPS cells.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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