Full Text:   <1896>

Summary:  <1750>

CLC number: R782.2

On-line Access: 2015-01-05

Received: 2014-07-08

Revision Accepted: 2014-10-23

Crosschecked: 2014-12-15

Cited: 2

Clicked: 3813

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Jiyeon KIM

http://orcid.org/0000-0003-3467-1454

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Journal of Zhejiang University SCIENCE B 2015 Vol.16 No.1 P.46-51

http://doi.org/10.1631/jzus.B1400192


Growth effects of botulinum toxin type A injected unilaterally into the masseter muscle of developing rats


Author(s):  Chanyoung Park, Kitae Park, Jiyeon Kim

Affiliation(s):  Department of Pediatric Dentistry, Institute of Oral Health Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea; more

Corresponding email(s):   jychaee@pusan.ac.kr, jychaee@gmail.com

Key Words:  Botulinum toxin, Craniofacial growth, Mandible


Chanyoung Park, Kitae Park, Jiyeon Kim. Growth effects of botulinum toxin type A injected unilaterally into the masseter muscle of developing rats[J]. Journal of Zhejiang University Science B, 2015, 16(1): 46-51.

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author="Chanyoung Park, Kitae Park, Jiyeon Kim",
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DOI - 10.1631/jzus.B1400192


Abstract: 
Objective: To evaluate the effects of botulinum toxin type A (BTX-A) on mandible skeletal development by inducing muscle hypofunction. Methods: Four-week-old Sprague-Dawley rats (n=60) were divided into three groups: Group 1 animals served as controls and were injected with saline; Group 2 animals were injected unilaterally with BTX-A (the contralateral side was injected with saline); and Group 3 animals were injected bilaterally with BTX-A. In Group 2, the saline-injected side was designated the control side (Group 2-1), whereas the BTX-A-injected side was designated the experimental side (Group 2-2). After four weeks, the animals were sacrificed, dry skulls were prepared, and mandibles were measured. Results: In the unilateral group, the experimental side (Group 2-2) had reduced dimensions for all mandible measurements compared with the control side (Group 2-1), suggesting a local effect of BTX-A on mandible growth, likely due to muscle reduction. Conclusions: Localized BTX-A injection induced a change in craniofacial growth, and the skeletal effect was unilateral despite both sides of the mandible functioning as one unit.

咬肌单侧注射A型肉毒毒素对大鼠下颌骨生长发育的影响

目的:通过诱导肌肉功能衰退,评估A型肉毒毒素(BTX-A)对下颌骨生长发育的影响。
创新点:通过对同一个体的对照侧(组2-1)和实验侧(组2-2)下颌骨尺寸的测量分析,证明BTX-A对下颌骨生长具有局部效应。
方法:四周龄的Sprague-Dawley大鼠(60只)随机分为三组:第1组动物注射生理盐水作为对照组;第2组动物单侧注射BTX-A(对侧注射生理盐水);第3组动物双侧注射BTX-A。在第2组中,注射生理盐水的一侧作为对照侧(组2-1),而BTX-A注射的一侧作为实验侧(组2-2)。四周后,处死动物,制备干头骨,测量下颌骨。
结论:尽管下颌骨的两侧作为一个功能单元,但是局部注射BTX-A诱导产生的颅面生长改变以及对骨骼的影响却是单侧的。

关键词:肉毒毒素;颅面生长;下颌骨

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

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Open peer comments: Debate/Discuss/Question/Opinion

<1>

Peyman@Bahadoran<bahadoran_peyman@yahoo.com>

2016-03-08 04:27:36

Hi I'm dnwtristy student in CEU in Manila,Philippines I have passed 4 terms of dentristy I would like to know how can I transfer to zhejiayng university of dentristy?

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