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Journal of Zhejiang University SCIENCE B 2007 Vol.8 No.8 P.575-579

http://doi.org/10.1631/jzus.2007.B0575


Effect of a distal protection device on epicardial blood flow and myocardial perfusion in primary percutaneous coronary intervention


Author(s):  ZHOU Bin-quan, TAHK Seung-Jea

Affiliation(s):  Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China; more

Corresponding email(s):   zhoubq@hotmail.com

Key Words:  Acute myocardial infarction (AMI), Distal protection device, Percutaneous coronary intervention (PCI)


ZHOU Bin-quan, TAHK Seung-Jea. Effect of a distal protection device on epicardial blood flow and myocardial perfusion in primary percutaneous coronary intervention[J]. Journal of Zhejiang University Science B, 2007, 8(8): 575-579.

@article{title="Effect of a distal protection device on epicardial blood flow and myocardial perfusion in primary percutaneous coronary intervention",
author="ZHOU Bin-quan, TAHK Seung-Jea",
journal="Journal of Zhejiang University Science B",
volume="8",
number="8",
pages="575-579",
year="2007",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2007.B0575"
}

%0 Journal Article
%T Effect of a distal protection device on epicardial blood flow and myocardial perfusion in primary percutaneous coronary intervention
%A ZHOU Bin-quan
%A TAHK Seung-Jea
%J Journal of Zhejiang University SCIENCE B
%V 8
%N 8
%P 575-579
%@ 1673-1581
%D 2007
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2007.B0575

TY - JOUR
T1 - Effect of a distal protection device on epicardial blood flow and myocardial perfusion in primary percutaneous coronary intervention
A1 - ZHOU Bin-quan
A1 - TAHK Seung-Jea
J0 - Journal of Zhejiang University Science B
VL - 8
IS - 8
SP - 575
EP - 579
%@ 1673-1581
Y1 - 2007
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2007.B0575


Abstract: 
Objective: The beneficial effect of percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI) has been well established, but there is the problem of no-reflow phenomenon which is an adverse prognostic factor in primary PCI. In the present study the effect of a distal protection device (PercuSurge GuardWire; GW) on epicardial blood flow and myocardial perfusion was evaluated. Methods and Results: Patients with AMI were randomly divided into 2 groups, the GW and the control groups. The GW group included 52 patients with AMI who underwent primary PCI with GW protection and the control group included 60 patients who underwent primary PCI without GW protection. Epicardial blood flow in the infarct-related artery (IRA) and myocardial perfusion were evaluated according to the thrombolysis in myocardial infarction (TIMI) flow grade and the myocardial blush grade (MBG). We found TIMI score of 3 was obtained significantly more frequently in the GW group (96%) than in the control group (80%). The MBG score of 3 was obtained also significantly greater in the GW group (65%) than in the control group (33%). Conclusion: Primary PCI with GW protection can significantly improve epicardial blood flow and myocardial perfusion.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1] Baim, D.S., Wahr, D., George, B., Leon, M.B., Greenberg, J., Cutlip, D.E., Kaya, U., Popma, J.J., Ho, K.K., Kuntz, R.E., 2002. Randomized trial of a distal embolic protection device during percutaneous intervention of saphenous vein aorto-coronary bypass grafts. Circulation, 105(11):1285-1290.

[2] Gibson, C.M., Cannon, C.P., Murphy, S.A., Ryan, K.A., Mesley, R., Marble, S.J., McCabe, C.H., van de Werf, F., Braunwald, E., 2000. Relationship of TIMI myocardial perfusion grade to mortality after administration of thrombolytic drugs. Circulation, 101(2):125-130.

[3] Haager, P.K., Christott, P., Heussen, N., Dangas, G., Mehran, R., Leon, M.B., 2003. Prediction of clinical outcome after mechanical revascularization in acute myocardial infarction by markers of myocardial reperfusion. JACC, 41(4):532-538.

[4] Mizote, I., Ueda, Y., Ohtani, T., Shimizu, M., Takeda, Y., Oka, T., Tsujimoto, M., Hirayama, A., Hori, M., Kodama, K., 2005. Distal protection improved reperfusion and reduced left ventricular dysfunction in patients with acute myocardial infarction who had angioscopically defined ruptured plaque. Circulation, 112(7):1001-1007.

[5] Morishima, I., Sone, T., Mokuno, S., Taga, S., Shimauchi, A., Oki, Y., Kondo, J., Tsuboi, H., Sassa, H., 1995. Clinical significance of no-reflow phenomenon observed on angiography after treatment of acute myocardial infarction with percutaneous transluminal coronary angioplasty. Am. Heart J., 130(2):239-243.

[6] Morishima, I., Sone, T., Okumura, K., Tsuboi, H., Kondo, J., Mukawa, H., Matsui, H., Toki, Y., Ito, T., Hayakawa, T., 2000. Angiographic no-reflow phenomenon as a predictor of adverse long-term outcome in patients treated with percutaneous transluminal coronary angioplasty for first acute myocardial infarction. JACC, 36(4):1202-1209.

[7] Nakamura, T., Kubo, N., Seki, Y., Ikeda, N., Ishida, T., Funayama, H., Hashimoto, S., Yasu, T., Fujii, M., Kawakami, M., Saito, M., 2004. Effects of a distal protection device during primary stenting in patients with acute myocardial infarction. Circ. J., 68(8):763-768.

[8] Stone, G.W., Peterson, M.A., Lansky, A.J., Dangas, G., Mehran, R., Leon, M.B., 2002. Impact of normalized myocardial perfusion after successful angioplasty in acute myocardial infarction. JACC, 39(4):591-597.

[9] Stone, G.W., Webb, J., Cox, D.A., Brodie, B.R., Qureshi, M., Kalynych, A., Turco, M., Schultheiss, H.P., Dulas, D., Rutherford, B.D., et al., 2005. Distal microcirculatory protection during percutaneous coronary intervention in acute ST-segment elevation myocardial infarction: a randomized controlled trial. JAMA, 293(9):1063-1072.

[10] Topol, E.J., Yadav, J.S., 2000. Recognition of the importance of embolization in atherosclerotic vascular disease. Circulation, 101(5):570-580.

[11] van't Hof, A.W.J., Liem, A., Suryapranata, H., Hoorntje, J.C.A., de Boer, M.J., Zijlstra, F., 1998. Angiographic assessment of myocardial reperfusion in patients treated with primary angioplasty for acute myocardial infarction: myocardial blush grade. Zwolle Myocardial Infarction Study Group. Circulation, 97(23):2302-2306.

[12] Yoon, M.H., Tahk, S.J., Choi, S.Y., Choi, T.Y., Choi, B.J., Choi, J.H., Yoo, S.Y., Ahn, S.G., Zheng, Z.G., Hwang, G.S., Shin, J.H., 2006. Effect of distal protection device on the microvascular integrity in acute myocardial infarction during primary percutaneous coronary intervention. Circ. J., 70(10):1284-1289.

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