Similar articles

Abstract: In various studies, metastasis associated with colon cancer 1 (MACC1) has been frequently reported to be abnormally highly expressed in human lung cancer, colon cancer, and hepatocellular carcinoma. Our study focuses on the association of MACC1 expression with gastric cancer (GC). During our experiment, the MACC1 expression was tested in 105 GC samples using an immunohistochemical (IHC) method. The clinical characteristics and prognosis of these patients were summarized. During analysis, MACC1 distribution in GC samples with distant metastasis was higher than that in normal samples and in tumors with no dissemination. Subsequently, a lower 5-year survival rate had a strong correlation with high MACC1 expression. As a consequence, the present results suggest that MACC1 is more frequently expressed in a poor prognosis phenotype of GC and acts as a promising prognostic prediction parameter for GC.

This manuscript is submitted by an established clinical patient group with a history of working on the pathology and prognosis of gastric cancer. The experiments were logically designed; the conclusion is supported by the very nice experiment and detailed follow-up.

MACC1高表达促进胃癌的转移，缩短患者生存时间

[1]Arlt, F., Stein, U., 2009. Colon cancer metastasis: MACC1 and Met as metastatic pacemakers. Int. J. Biochem. Cell Biol., 41(12):2356-2359.

[2]Chundong, G., Uramoto, H., Onitsuka, T., et al., 2011. Molecular diagnosis of MACC1 status in lung adenocarcinoma by IHC analysis. Anticancer Res., 31(4):1141-1145.

[3]Edge, S.B., Compton, C.C., 2010. The American Joint Committee on cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann. Surg. Oncol., 17(6):1471-1474.

[4]Ge, S.H., Wu, X.J., Wang, X.H., et al., 2011. Over-expression of metastasis-associated in colon cancer-1 (MACC1) associates with better prognosis of gastric cancer patients. Chin. J. Cancer Res., 23(2):153-159.

[5]González, C.A., Sala, N., Capella, G., 2002. Genetic susceptibility and gastric cancer risk. Int. J. Cancer, 100(3):249-260.

[6]Guo, T., Yang, J., Yao, J., et al., 2013. Expression of MACC1 and c-Met in human gastric cancer and its clinical significance. Cancer Cell Int., 13(1):121.

[7]Hamajima, N., Naito, M., Kondo, T., et al., 2006. Genetic factors involved in the development of Helicobacter pylori-related gastric cancer. Cancer Sci., 97(11):1129-1138.

[8]Huang, N., Wu, Z., Lin, L., et al., 2015. MiR-338-3p inhibits epithelial-mesenchymal transition in gastric cancer cells by targeting ZEB2 and MACC1/Met/Akt signaling. Oncotarget, 6(17):15222-15234.

[9]Huang, Y., Zhang, H., Cai, J., et al., 2013. Overexpression of MACC1 and its significance in human breast cancer progression. Cell Biosci., 3(1):16-28.

[10]Jemal, A., Bray, F., Center, M.M., et al., 2011. Global cancer statistics. CA Cancer J. Clin., 61(2):69-90.

[11]Lee, J.H., Ryu, K.W., Kook, M.C., et al., 2008. Feasibility of laparoscopic sentinel basin dissection for limited resection in early gastric cancer. J. Surg. Oncol., 98(5):331-335.

[12]Lin, L., Huang, H., Liao, W., et al., 2015. MACC1 supports human gastric cancer growth under metabolic stress by enhancing the Warburg effect. Oncogene, 34(21):2700-2710.

[13]MacDonald, J.S., 2006. Gastric cancer—new therapeutic options. N. Engl. J. Med., 355(1):76-77.

[14]Morabito, A., Carillio, G., Longo, R., 2009. Systemic treatment of gastric cancer. Crit. Rev. Oncol. Hematol., 70(3):216-234.

[15]Qiu, J., Huang, P., Liu, Q., et al., 2011. Identification of MACC1 as a novel prognostic marker in hepatocellular carcinoma. J. Transl. Med., 9(1):166.

[16]Shimokawa, H., Uramoto, H., Onitsuka, T., et al., 2011. Overexpression of MACC1 mRNA in lung adenocarcinoma is associated with postoperative recurrence. J. Thorac. Cardiovasc. Surg., 141(4):895-898.

[17]Shirahata, A., Shinmura, K., Kitamura, Y., et al., 2010a. MACC1 as a marker for advanced colorectal carcinoma. Anticancer Res., 30(7):2689-2692.

[18]Shirahata, A., Sakata, M., Kitamura, Y., et al., 2010b. MACC 1 as a marker for peritoneal-disseminated gastric carcinoma. Anticancer Res., 30(9):3441-3444.

[19]Shirahata, A., Fan, W., Sakuraba, K., et al., 2011. MACC 1 as a marker for vascular invasive hepatocellular carcinoma. Anticancer Res., 31(3):777-780.

[20]Stein, U., Walther, W., Arlt, F., et al., 2009. MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis. Nat. Med., 15(1):59-67.

[21]Sun, L., Duan, J., Jiang, Y., et al., 2015. Metastasis-associated in colon cancer-1 upregulates vascular endothelial growth factor-C/D to promote lymphangiogenesis in human gastric cancer. Cancer Lett., 357(1):242-253.

[22]Sun, P., Xiang, J.B., Chen, Z.Y., 2009. Meta-analysis of adjuvant chemotherapy after radical surgery for advanced gastric cancer. Br. J. Surg., 96(1):26-33.

[23]Wang, L., Wu, Y., Lin, L., et al., 2013. Metastasis-associated in colon cancer-1 upregulation predicts a poor prognosis of gastric cancer, and promotes tumor cell proliferation and invasion. Int. J. Cancer, 133(6):1419-1430.

[24]Wang, L., Lin, L., Chen, X., et al., 2015. Metastasis-associated in colon cancer-1 promotes vasculogenic mimicry in gastric cancer by upregulating TWIST1/2. Oncotarget, 6(13):11492-11506.

[25]Wang, Z., Li, Z., Wu, C., et al., 2014. MACC1 overexpression predicts a poor prognosis for non-small cell lung cancer. Med. Oncol., 31(1):790.

[26]Weidle, U.H., Birzele, F., Kruger, A., 2015. Molecular targets and pathways involved in liver metastasis of colorectal cancer. Clin. Exp. Metastasis, 32(6):623-635.

[27]Xu, S.T., Ding, X., Ni, Q.F., et al., 2015. Targeting MACC1 by RNA interference inhibits proliferation and invasion of bladder urothelial carcinoma in T24 cells. Int. J. Clin. Exp. Pathol., 8(7):7937-7944.

[28]Zhou, X., Xu, C.J., Wang, J.X., et al., 2015. Metastasis-associated in colon cancer-1 associates with poor prognosis and promotes cell invasion and angiogenesis in human cervical cancer. Int. J. Gynecol. Cancer, 25(8):1353-1363.

[29]Zhu, M., Xu, Y., Mao, X., et al., 2013. Overexpression of metastasis-associated in colon cancer-1 associated with poor prognosis in patients with esophageal cancer. Pathol. Oncol. Res., 19(4):749-753.