Full Text:   <1693>

Summary:  <1569>

CLC number: R737.33

On-line Access: 2015-05-04

Received: 2014-09-22

Revision Accepted: 2015-01-16

Crosschecked: 2015-04-22

Cited: 2

Clicked: 3546

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Xiang Zhang

http://orcid.org/0000-0002-6706-3925

Yue Yang

http://orcid.org/0000-0001-8438-6905

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Journal of Zhejiang University SCIENCE B 2015 Vol.16 No.5 P.388-394

http://doi.org/10.1631/jzus.B1400251


Treatment and prognosis of cervical cancer associated with pregnancy: analysis of 20 cases from a Chinese tumor institution


Author(s):  Xiang Zhang, Yong-liang Gao, Yue Yang

Affiliation(s):  Department of Gynecological Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China; more

Corresponding email(s):   yangyue@zjcc.org.cn

Key Words:  Cervical cancer, Pregnancy, Treatment, Prognosis


Xiang Zhang, Yong-liang Gao, Yue Yang. Treatment and prognosis of cervical cancer associated with pregnancy: analysis of 20 cases from a Chinese tumor institution[J]. Journal of Zhejiang University Science B, 2015, 16(5): 388-394.

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DOI - 10.1631/jzus.B1400251


Abstract: 
This study was designed to investigate the therapeutic approaches and prognosis for cervical cancer associated with pregnancy. Clinical information, therapeutic strategies, and follow-up results of 20 patients with cervical cancer associated with pregnancy from Jan. 2000 to June 2009 in the Zhejiang Cancer Hospital were retrospectively analyzed. The International Federation of Gynecology and Obstetrics (FIGO) stages were: in situ (n=1), stage IA1 (n=1), stage IB1 (n=5), stage IB2 (n=1), stage IIA (n=8), stage IIB (n=3), and stage IIIB (n=1). Eight patients were in the first trimester of pregnancy, four in the second, two in the third, and six at postpartum when diagnosed. The therapeutic strategies were either single or combined modalities, including surgery, radiotherapy, and chemotherapy. Fourteen patients survived, five patients died (four of remote metastasis and one of uremia), and one patient was lost to follow-up. One newborn from a patient at stage IIA carcinoma in the third trimester with postponed therapy six weeks after diagnosis survived. Retarded fetal growth was observed in one patient receiving neoadjuvant chemotherapy and cesarean section. Out of the six postpartum patients, three underwent cesarean section and survived, whereas only one out of the three who underwent vaginal delivery survived. The remaining two died of remote metastasis. Therefore, personalized treatment is necessary for cervical cancer associated with pregnancy. cervical cancer patients in the third trimester of pregnancy can continue the pregnancy for a short period of time. There may be potential risk for the fetus by chemotherapy during pregnancy. Cesarean section is the preferred mode of delivery for pregnant cervical cancer patients.

妊娠相关性宫颈癌20例临床分析

目的:探讨妊娠相关性宫颈癌合适的治疗方式,包括维持妊娠、针对肿瘤的治疗、分娩方式,以及预后。
创新点:在发展中国家对妊娠相关性宫颈癌治疗和分娩方式的选择,以及相关预后。
方法:回顾性分析2000年到2009年浙江省肿瘤医院收治的20例妊娠相关性宫颈癌患者的临床资料、治疗方案及随访结果。
结论:妊娠中晚期患者可选择在短期内继续妊娠;新辅助化疗对胎儿可能有影响;对合并宫颈癌的患者,剖宫产术是较阴道分娩更合适的方式。

关键词:宫颈癌;妊娠;治疗;预后

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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