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CLC number: R734.2; R34

On-line Access: 2016-05-04

Received: 2015-10-27

Revision Accepted: 2016-01-05

Crosschecked: 2016-04-15

Cited: 2

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Zeng-hui Cheng


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Journal of Zhejiang University SCIENCE B 2016 Vol.17 No.5 P.342-351


Chemokines and their receptors in lung cancer progression and metastasis

Author(s):  Zeng-hui Cheng, Yu-xin Shi, Min Yuan, Dan Xiong, Jiang-hua Zheng, Zhi-yong Zhang

Affiliation(s):  Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China; more

Corresponding email(s):   zhengjianghua2014@163.com, zhangzy@shaphc.org

Key Words:  Lung cancer, Chemokines, Tumor progression, Metastasis

Zeng-hui Cheng, Yu-xin Shi, Min Yuan, Dan Xiong, Jiang-hua Zheng, Zhi-yong Zhang. Chemokines and their receptors in lung cancer progression and metastasis[J]. Journal of Zhejiang University Science B, 2016, 17(5): 342-351.

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author="Zeng-hui Cheng, Yu-xin Shi, Min Yuan, Dan Xiong, Jiang-hua Zheng, Zhi-yong Zhang",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Chemokines and their receptors in lung cancer progression and metastasis
%A Zeng-hui Cheng
%A Yu-xin Shi
%A Min Yuan
%A Dan Xiong
%A Jiang-hua Zheng
%A Zhi-yong Zhang
%J Journal of Zhejiang University SCIENCE B
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%D 2016
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1500258

T1 - Chemokines and their receptors in lung cancer progression and metastasis
A1 - Zeng-hui Cheng
A1 - Yu-xin Shi
A1 - Min Yuan
A1 - Dan Xiong
A1 - Jiang-hua Zheng
A1 - Zhi-yong Zhang
J0 - Journal of Zhejiang University Science B
VL - 17
IS - 5
SP - 342
EP - 351
%@ 1673-1581
Y1 - 2016
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1500258

lung cancer is the leading cause of cancer-related mortality around the world. Despite advancements in diagnosis, surgical techniques, and neoadjuvant chemoradiotherapy over the last decade, the mortality rate is still high and the 5-year survival is a dismal 15%. Fortunately, early detection by low-dose computed tomography (LDCT) scans has reduced mortality by 20%; yet, overall, 5-year-survival remains low at less than 20%. Therefore, in order to ameliorate this situation, a thorough understanding of the underlying molecular mechanisms is urgently needed. chemokines and their receptors, crucial microenvironmental factors, play important roles in lung tumor genesis, progression, and metastasis, and exploring the mechanisms of this might bring new insights into early diagnosis and precisely targeted treatment. Consequently, this review will mainly focus on recent advancements on the axes of chemokines and their receptors of lung cancer.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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