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CLC number: R684.3

On-line Access: 2016-03-07

Received: 2015-11-04

Revision Accepted: 2015-12-27

Crosschecked: 2016-02-15

Cited: 3

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Citations:  Bibtex RefMan EndNote GB/T7714

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Journal of Zhejiang University SCIENCE B 2016 Vol.17 No.3 P.200-208

http://doi.org/10.1631/jzus.B1500267


Roles of microRNA and signaling pathway in osteoarthritis pathogenesis


Author(s):  Bin Xu, Yao-yao Li, Jun Ma, Fu-xing Pei

Affiliation(s):  Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, China; more

Corresponding email(s):   spot125@163.com

Key Words:  MicroRNA, Signaling pathway, Osteoarthritis, Pathogenesis


Bin Xu, Yao-yao Li, Jun Ma, Fu-xing Pei. Roles of microRNA and signaling pathway in osteoarthritis pathogenesis[J]. Journal of Zhejiang University Science B, 2016, 17(3): 200-208.

@article{title="Roles of microRNA and signaling pathway in osteoarthritis pathogenesis",
author="Bin Xu, Yao-yao Li, Jun Ma, Fu-xing Pei",
journal="Journal of Zhejiang University Science B",
volume="17",
number="3",
pages="200-208",
year="2016",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1500267"
}

%0 Journal Article
%T Roles of microRNA and signaling pathway in osteoarthritis pathogenesis
%A Bin Xu
%A Yao-yao Li
%A Jun Ma
%A Fu-xing Pei
%J Journal of Zhejiang University SCIENCE B
%V 17
%N 3
%P 200-208
%@ 1673-1581
%D 2016
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1500267

TY - JOUR
T1 - Roles of microRNA and signaling pathway in osteoarthritis pathogenesis
A1 - Bin Xu
A1 - Yao-yao Li
A1 - Jun Ma
A1 - Fu-xing Pei
J0 - Journal of Zhejiang University Science B
VL - 17
IS - 3
SP - 200
EP - 208
%@ 1673-1581
Y1 - 2016
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1500267


Abstract: 
osteoarthritis (OA) is a common chronic degenerative joint disease, with complicated pathogenic factors and undefined pathogenesis. Various signaling pathways play important roles in OA pathogenesis, including genetic expression, matrix synthesis and degradation, cell proliferation, differentiation, apoptosis, and so on. microRNA (miRNA) is a class of non-coding RNA in Eukaryon, regulating genetic expression on the post-transcriptional level. A great number of miRNAs are involved in the development of OA, and are closely associated with different signaling pathways. This article reviews the roles of miRNAs and signaling pathways in OA, looking toward having a better understanding of its pathogenesis mechanisms and providing new therapeutic targets for its treatment.

MicroRNA与信号通路在骨关节炎发病机制中的作用

概要:通过综述microRNA及信号通路在骨关节炎发病机制中参与基因表达、基质代谢及细胞周期等生理过程的作用,以及整理两者之间的关系,为更好地理解其发病机制,提供了新的治疗靶点及途径。
关键词:MicroRNA;信号通路;骨关节炎;发病机制

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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