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CLC number: R684.3

On-line Access: 2016-03-07

Received: 2015-11-04

Revision Accepted: 2015-12-27

Crosschecked: 2016-02-15

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Citations:  Bibtex RefMan EndNote GB/T7714

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Journal of Zhejiang University SCIENCE B 2016 Vol.17 No.3 P.200-208


Roles of microRNA and signaling pathway in osteoarthritis pathogenesis

Author(s):  Bin Xu, Yao-yao Li, Jun Ma, Fu-xing Pei

Affiliation(s):  Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, China; more

Corresponding email(s):   spot125@163.com

Key Words:  MicroRNA, Signaling pathway, Osteoarthritis, Pathogenesis

Bin Xu, Yao-yao Li, Jun Ma, Fu-xing Pei. Roles of microRNA and signaling pathway in osteoarthritis pathogenesis[J]. Journal of Zhejiang University Science B, 2016, 17(3): 200-208.

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author="Bin Xu, Yao-yao Li, Jun Ma, Fu-xing Pei",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Roles of microRNA and signaling pathway in osteoarthritis pathogenesis
%A Bin Xu
%A Yao-yao Li
%A Jun Ma
%A Fu-xing Pei
%J Journal of Zhejiang University SCIENCE B
%V 17
%N 3
%P 200-208
%@ 1673-1581
%D 2016
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1500267

T1 - Roles of microRNA and signaling pathway in osteoarthritis pathogenesis
A1 - Bin Xu
A1 - Yao-yao Li
A1 - Jun Ma
A1 - Fu-xing Pei
J0 - Journal of Zhejiang University Science B
VL - 17
IS - 3
SP - 200
EP - 208
%@ 1673-1581
Y1 - 2016
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1500267

osteoarthritis (OA) is a common chronic degenerative joint disease, with complicated pathogenic factors and undefined pathogenesis. Various signaling pathways play important roles in OA pathogenesis, including genetic expression, matrix synthesis and degradation, cell proliferation, differentiation, apoptosis, and so on. microRNA (miRNA) is a class of non-coding RNA in Eukaryon, regulating genetic expression on the post-transcriptional level. A great number of miRNAs are involved in the development of OA, and are closely associated with different signaling pathways. This article reviews the roles of miRNAs and signaling pathways in OA, looking toward having a better understanding of its pathogenesis mechanisms and providing new therapeutic targets for its treatment.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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