Full Text:   <1531>

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CLC number: R591.44

On-line Access: 2016-07-06

Received: 2015-11-19

Revision Accepted: 2016-03-08

Crosschecked: 2016-06-18

Cited: 3

Clicked: 3088

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Xiao-wei Zhao

http://orcid.org/0000-0003-3315-3866

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Journal of Zhejiang University SCIENCE B 2016 Vol.17 No.7 P.545-552

http://doi.org/10.1631/jzus.B1500285


Vitamin D status among infants, children, and adolescents in southeastern China


Author(s):  Ling-li Wang, Hui-yan Wang, Huai-kai Wen, Hong-qun Tao, Xiao-wei Zhao

Affiliation(s):  Unit of Laboratory Medicine, Second Hospital Affiliated to Wenzhou Medical University, Wenzhou 325027, China; more

Corresponding email(s):   sherwood@wzu.edu.cn

Key Words:  Vitamin D, Deficiency, Child, China


Ling-li Wang, Hui-yan Wang, Huai-kai Wen, Hong-qun Tao, Xiao-wei Zhao. Vitamin D status among infants, children, and adolescents in southeastern China[J]. Journal of Zhejiang University Science B, 2016, 17(7): 545-552.

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author="Ling-li Wang, Hui-yan Wang, Huai-kai Wen, Hong-qun Tao, Xiao-wei Zhao",
journal="Journal of Zhejiang University Science B",
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publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1500285"
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%T Vitamin D status among infants, children, and adolescents in southeastern China
%A Ling-li Wang
%A Hui-yan Wang
%A Huai-kai Wen
%A Hong-qun Tao
%A Xiao-wei Zhao
%J Journal of Zhejiang University SCIENCE B
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%DOI 10.1631/jzus.B1500285

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T1 - Vitamin D status among infants, children, and adolescents in southeastern China
A1 - Ling-li Wang
A1 - Hui-yan Wang
A1 - Huai-kai Wen
A1 - Hong-qun Tao
A1 - Xiao-wei Zhao
J0 - Journal of Zhejiang University Science B
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1500285


Abstract: 
Objective: vitamin D deficiency and insufficiency are global public health problems, which must first be identified before they can be appropriately addressed, and yet information is strikingly lacking in most parts of the Asia and Pacific region. The study aimed to document and account for the actual situation in Wenzhou on the southeastern coast of china. Subjects and methods: Serum 25-hydroxyvitamin D levels among a total of 5845 infants, preschool children, school children, and adolescents aged 1–18 years were examined between March 2014 and February 2015. Results: Their mean levels were (110.2±26.8), (77.5±25.7), (55.6±15.4), and (47.2±13.9) nmol/L, respectively. Older age groups were involved in increasing risk of vitamin D deficiency and insufficiency. There were significant seasonal differences in its median level and prevalence of deficiency and insufficiency among school children and adolescents, but there was no significant sex difference in mean level and prevalence in any age group. Conclusions: vitamin D deficiency and insufficiency were prevalent among infants, preschool children, school children, and adolescents in Wenzhou. A vitamin D-rich diet and outdoor activities for 1–2 h per day under the natural conditions favorable to its endogeous synthesis do not suffice. The vitamin D status in Wenzhounese infants excelling over that in the US was the result of its supplementation thanks to the Chinese Medical Association recommendations, which should be consequently extended to more age groups. Life style shaped by socio-economic environments affects vitamin D status. Knowledge on the importance of vitamin D for healthy growth should be popularized.

中国东南地区婴儿、儿童与少年的维生素D状态

目的:维生素D缺乏和不足是全球性的公共卫生问题,欲妥善解决,必首先了解之。
创新点:大部分亚太地区关于维生素D状态的信息奇缺,本研究记录与分析了地处中国东南沿海的温州的实际状况。
方法:2014年3月至2015年2月之间,总共检测了5845名年龄在1~18岁的婴儿、学前儿童、学龄儿童与少年的血清25-羟基维生素D水平。其均数分别为(110.2±26.8)、(77.5±25.7)、(55.6±15.4)与(47.2±13.9)nmol/L。随着年龄增大,发生维生素D缺乏和不足的风险升高。学龄儿童与少年的中位数与维生素D缺乏和不足发生率存在显著的季节差异,而所有年龄段的均数与发生率不存在显著的性别差异。
结论:维生素D缺乏和不足普遍发生于温州的婴儿、学前儿童、学龄儿童与少年,富含维生素D的饮食与在有利于维生素D内源性合成的自然条件下每天户外活动1~2小时并不能满足需求。温州婴儿的维生素D状态优于美国婴儿,是因为中国医学会自2008年以来推荐2周至2岁的婴幼儿应每天摄入400 IU维生素D,自2009年以来推荐3岁以下的婴幼儿应喂食维生素D强化食物,因此,其推荐范围应当扩展至更多年龄段。因社会经济环境形成的生活方式影响维生素D状态,应当广泛宣传关于维生素D对于健康生长至关重要的知识。

关键词:维生素D;缺乏;儿童;中国

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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