CLC number: R589
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2016-10-18
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Rados?aw Wieczr, Anna Maria Wieczr, Gra?yna Gadomska, Katarzyna Stankowska, Jacek Fabisiak, Karol Suppan, Grzegorz Pulkowski, Jacek Budzy?ski, Danuta Ro??. Overweight and obesity versus concentrations of VEGF-A, sVEGFR-1, and sVEGFR-2 in plasma of patients with lower limb chronic ischemia[J]. Journal of Zhejiang University Science B, 2016, 17(11): 842-849.
@article{title="Overweight and obesity versus concentrations of VEGF-A, sVEGFR-1, and sVEGFR-2 in plasma of patients with lower limb chronic ischemia",
author="Rados?aw Wieczr, Anna Maria Wieczr, Gra?yna Gadomska, Katarzyna Stankowska, Jacek Fabisiak, Karol Suppan, Grzegorz Pulkowski, Jacek Budzy?ski, Danuta Ro??",
journal="Journal of Zhejiang University Science B",
volume="17",
number="11",
pages="842-849",
year="2016",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1600009"
}
%0 Journal Article
%T Overweight and obesity versus concentrations of VEGF-A, sVEGFR-1, and sVEGFR-2 in plasma of patients with lower limb chronic ischemia
%A Rados?aw Wieczr
%A Anna Maria Wieczr
%A Gra?yna Gadomska
%A Katarzyna Stankowska
%A Jacek Fabisiak
%A Karol Suppan
%A Grzegorz Pulkowski
%A Jacek Budzy?ski
%A Danuta Ro??
%J Journal of Zhejiang University SCIENCE B
%V 17
%N 11
%P 842-849
%@ 1673-1581
%D 2016
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1600009
TY - JOUR
T1 - Overweight and obesity versus concentrations of VEGF-A, sVEGFR-1, and sVEGFR-2 in plasma of patients with lower limb chronic ischemia
A1 - Rados?aw Wieczr
A1 - Anna Maria Wieczr
A1 - Gra?yna Gadomska
A1 - Katarzyna Stankowska
A1 - Jacek Fabisiak
A1 - Karol Suppan
A1 - Grzegorz Pulkowski
A1 - Jacek Budzy?ski
A1 - Danuta Ro??
J0 - Journal of Zhejiang University Science B
VL - 17
IS - 11
SP - 842
EP - 849
%@ 1673-1581
Y1 - 2016
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1600009
Abstract: Objective: Being overweight or obese comprises a significant risk factor for atherosclerosis. Fat tissue also generates factors stimulating angiogenesis, the process by which new blood vessels form. The purpose of this paper is to assess concentrations of the vascular endothelial growth factor A (VEGF-A) and its soluble type-1 and type-2 receptors (sVEGFR-1 and sVEGFR-2) in plasma of patients with peripheral arterial disease (PAD) depending on the level of nutrition according to body mass index (BMI). Methods: The study group included patients suffering from symptomatic PAD (n=46) in Fontaine classes IIa–IV without any history of neoplastic disease and who have a normal BMI (n=15), are overweight (n=21) or are obese (n=10). The control group (n=30) consisted of healthy non-smoking volunteers who were neither overweight nor obese. Venous blood plasma samples were collected from both groups at rest in the morning to determine plasma concentrations of VEGF-A, sVEGFR-1, and sVEGFR-2 using the enzyme-linked immunosorbent assay (ELISA) method. Results: The group of patients with PAD co-existent with being overweight or obese tended to have higher mean concentration levels of VEGF-A and sVEGFR-2 when compared with patients suffering from PAD with normal BMI. A statistically significant positive correlation was obtained between BMI and average plasma concentrations of sVEGFR-2 (R=0.37, P=0.0103). However, no significant correlation was noticed between BMI and VEGF-A or sVEGFR-1 concentrations. Conclusions: A positive correlation determined between the level of antiangiogenic factor and BMI value may be indicative of the linearly growing prevalence of some antiangiogenic factors in patients with metabolic disorders, which may be one of numerous factors contributing to incomplete efficiency of collateral circulation development in patients with PAD.
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