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Jian-an Wang


De-xing Hu


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Journal of Zhejiang University SCIENCE B 2016 Vol.17 No.11 P.821-830


Roles of SIRT3 in heart failure: from bench to bedside

Author(s):  De-xing Hu, Xian-bao Liu, Wen-chao Song, Jian-an Wang

Affiliation(s):  Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China; more

Corresponding email(s):   21318074@zju.edu.cn, jian_an_wang@yahoo.com

Key Words:  SIRT3, Heart failure, Hypertrophy, Ischemia reperfusion

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De-xing Hu, Xian-bao Liu, Wen-chao Song, Jian-an Wang. Roles of SIRT3 in heart failure: from bench to bedside[J]. Journal of Zhejiang University Science B, 2016, 17(11): 821-830.

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author="De-xing Hu, Xian-bao Liu, Wen-chao Song, Jian-an Wang",
journal="Journal of Zhejiang University Science B",
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%T Roles of SIRT3 in heart failure: from bench to bedside
%A De-xing Hu
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%A Wen-chao Song
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%J Journal of Zhejiang University SCIENCE B
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1600253

T1 - Roles of SIRT3 in heart failure: from bench to bedside
A1 - De-xing Hu
A1 - Xian-bao Liu
A1 - Wen-chao Song
A1 - Jian-an Wang
J0 - Journal of Zhejiang University Science B
VL - 17
IS - 11
SP - 821
EP - 830
%@ 1673-1581
Y1 - 2016
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1600253

heart failure (HF) represents the most common endpoint of most cardiovascular diseases (CVDs) which are the leading causes of death around the world. Despite the advances in treating CVDs, the prevalence of HF continues to increase. It is believed that better results of prognosis are obtained from prevention rather than additional treatment for HF. Therefore, it is reasonable to prevent the development of CVDs or other complications to HF. Most types of HF are attributed to contractile dysfunction, cardiac hypertrophy or remodeling, and ischemic injuries. SIRT3 is a mitochondrial nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase whose substrates vary from metabolic biogenesis-associated proteins to stress-responsive proteins. In recent years, a number of studies have highlighted the cardio-protective role of SIRT3 and, as such, efforts have been made to induce over-expression or increased activity of this protein. In this review, we provide an overview of the roles of SIRT3 in cardiac hypertrophy induced by pressure overload or agonists and cardiomyocytes ischemic injuries. Moreover, we will introduce the application of SIRT3 agonists in the prevention of cardiac hypertrophy and ischemia reperfusion injury.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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