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CLC number: R736.1

On-line Access: 2017-05-04

Received: 2016-07-05

Revision Accepted: 2016-08-26

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Journal of Zhejiang University SCIENCE B 2017 Vol.18 No.5 P.430-436


Clinical characteristics and treatment of thyroid cancer in children and adolescents: a retrospective analysis of 83 patients

Author(s):  Xiao-chun Mao, Wen-qiao Yu, Jin-biao Shang, Ke-jing Wang

Affiliation(s):  Department of Head and Neck Surgery, Zhejiang Cancer Hospital, Hangzhou 310011, China; more

Corresponding email(s):   maoxiaochun@hotmail.com, Wangkejing2016@hotmail.com

Key Words:  Children and adolescents, Thyroid cancer, Clinical characteristics, Surgical treatment

Xiao-chun Mao, Wen-qiao Yu, Jin-biao Shang, Ke-jing Wang. Clinical characteristics and treatment of thyroid cancer in children and adolescents: a retrospective analysis of 83 patients[J]. Journal of Zhejiang University Science B, 2017, 18(5): 430-436.

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author="Xiao-chun Mao, Wen-qiao Yu, Jin-biao Shang, Ke-jing Wang",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Clinical characteristics and treatment of thyroid cancer in children and adolescents: a retrospective analysis of 83 patients
%A Xiao-chun Mao
%A Wen-qiao Yu
%A Jin-biao Shang
%A Ke-jing Wang
%J Journal of Zhejiang University SCIENCE B
%V 18
%N 5
%P 430-436
%@ 1673-1581
%D 2017
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1600308

T1 - Clinical characteristics and treatment of thyroid cancer in children and adolescents: a retrospective analysis of 83 patients
A1 - Xiao-chun Mao
A1 - Wen-qiao Yu
A1 - Jin-biao Shang
A1 - Ke-jing Wang
J0 - Journal of Zhejiang University Science B
VL - 18
IS - 5
SP - 430
EP - 436
%@ 1673-1581
Y1 - 2017
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1600308

Objective: To study the clinical characteristics, treatment, and prognosis of thyroid cancer in children and adolescents. Methods: We performed a retrospective analysis of clinical data from 83 cases of thyroid cancer in children and adolescents from January 1990 to December 2010. We compared extra-thyroid extension, lymph node metastasis, distant metastasis, and prognosis between pediatric patients ≤12 years of age (27 cases) and those >12 years of age (56 cases). All the patients agreed to undergo thyroidectomy and endocrine therapy, and the consent was obtained from parents or guardians. Results: Histopathology included papillary carcinoma in 67 cases, papillary carcinoma with partial follicular growth pattern in 1 case, papillary carcinoma with squamous metaplasia in 4 cases, follicular carcinoma in 7 cases, medullary carcinoma in 3 cases, and poorly differentiated carcinoma in 1 case. The total lymph node metastasis rate was 78.31%. Patients ≤12 years of age showed a higher rate of lymph node metastasis than the older group (92.59% vs. 71.43%, P=0.028). The incidence rate in females in the older group was higher than that in the younger group (80.36% vs. 59.26%, P=0.041). There were no significant differences in extra-thyroid extension, distant metastasis, survival rate, or recurrent disease between the two groups. Conclusions: The lymph node metastasis of thyroid cancer is higher in patients ≤12 years of age than in those >12 years of age; the incidence rate is higher in females than in males. Childhood thyroid cancer has a good prognosis, surgery being the most effective treatment. Choosing a reasonable surgery method and comprehensive postoperative treatment can achieve a cure and satisfactory survival rate.




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