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CLC number: R725.8

On-line Access: 2018-09-30

Received: 2018-03-14

Revision Accepted: 2018-08-03

Crosschecked: 2018-09-10

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Citations:  Bibtex RefMan EndNote GB/T7714


Jian-fang Zhu


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Journal of Zhejiang University SCIENCE B 2018 Vol.19 No.10 P.807-814


Dopamine receptor D2 polymorphism is associated with alleviation of obesity after 8-year follow-up: a retrospective cohort study in obese Chinese children and adolescents

Author(s):  Jian-fang Zhu, Lian-hui Chen, Ke Yuan, Li Liang, Chun-lin Wang

Affiliation(s):  Department of Pediatrics, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; more

Corresponding email(s):   hzwangcl@zju.edu.cn

Key Words:  Obesity, Follow-up study, Dopamine receptor D2, Children, Adolescent

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Jian-fang Zhu, Lian-hui Chen, Ke Yuan, Li Liang, Chun-lin Wang. Dopamine receptor D2 polymorphism is associated with alleviation of obesity after 8-year follow-up: a retrospective cohort study in obese Chinese children and adolescents[J]. Journal of Zhejiang University Science B, 2018, 19(10): 807-814.

@article{title="Dopamine receptor D2 polymorphism is associated with alleviation of obesity after 8-year follow-up: a retrospective cohort study in obese Chinese children and adolescents",
author="Jian-fang Zhu, Lian-hui Chen, Ke Yuan, Li Liang, Chun-lin Wang",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Dopamine receptor D2 polymorphism is associated with alleviation of obesity after 8-year follow-up: a retrospective cohort study in obese Chinese children and adolescents
%A Jian-fang Zhu
%A Lian-hui Chen
%A Ke Yuan
%A Li Liang
%A Chun-lin Wang
%J Journal of Zhejiang University SCIENCE B
%V 19
%N 10
%P 807-814
%@ 1673-1581
%D 2018
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1800155

T1 - Dopamine receptor D2 polymorphism is associated with alleviation of obesity after 8-year follow-up: a retrospective cohort study in obese Chinese children and adolescents
A1 - Jian-fang Zhu
A1 - Lian-hui Chen
A1 - Ke Yuan
A1 - Li Liang
A1 - Chun-lin Wang
J0 - Journal of Zhejiang University Science B
VL - 19
IS - 10
SP - 807
EP - 814
%@ 1673-1581
Y1 - 2018
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1800155

Objective: The aim of this study was to explore the association of dopamine receptor D2 (DRD2) polymorphism and alleviation of obesity in children and adolescents after 8-year follow-up. Methods: This retrospective cohort study included obese children and adolescents with a follow-up period of 8 years. Baseline clinical characteristics and DRD2 polymorphisms (including rs1076562, rs2075654, and rs4586205) were extracted from medical records. A follow-up visit was performed in May 2017 to collect related data including height, weight, diet compliance, and exercise compliance. Results: One hundred and nine obese children and adolescents were included in the current study. Among three DRD2 single nucleotide polymorphisms, only rs2075654 had a statistically significant association with alleviation of obesity, as the alleviation rate for minor allele carriers (68.6% for TC+TT) was higher compared to the major allele homozygote (43.3% for CC). After adjusting for all related factors, the hazard ratio of rs2075654 minor allele carriers for the alleviation of obesity was 3.34 (95% confidence interval (CI): 1.30‒8.58). Conclusions: The rs2075654 polymorphism of DRD2 is related to long-term obesity alleviation in obese Chinese children and adolescents.


结论:DRD2基因rs2075654位点多态性与肥胖儿童青 少年的长期体重变化有相关性.


Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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