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CLC number: R725.8

On-line Access: 2018-09-30

Received: 2018-03-14

Revision Accepted: 2018-08-03

Crosschecked: 2018-09-10

Cited: 0

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Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Jian-fang Zhu

https://orcid.org/0000-0002-1580-0479

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Journal of Zhejiang University SCIENCE B 2018 Vol.19 No.10 P.807-814

http://doi.org/10.1631/jzus.B1800155


Dopamine receptor D2 polymorphism is associated with alleviation of obesity after 8-year follow-up: a retrospective cohort study in obese Chinese children and adolescents


Author(s):  Jian-fang Zhu, Lian-hui Chen, Ke Yuan, Li Liang, Chun-lin Wang

Affiliation(s):  Department of Pediatrics, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; more

Corresponding email(s):   hzwangcl@zju.edu.cn

Key Words:  Obesity, Follow-up study, Dopamine receptor D2, Children, Adolescent


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Jian-fang Zhu, Lian-hui Chen, Ke Yuan, Li Liang, Chun-lin Wang. Dopamine receptor D2 polymorphism is associated with alleviation of obesity after 8-year follow-up: a retrospective cohort study in obese Chinese children and adolescents[J]. Journal of Zhejiang University Science B, 2018, 19(10): 807-814.

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author="Jian-fang Zhu, Lian-hui Chen, Ke Yuan, Li Liang, Chun-lin Wang",
journal="Journal of Zhejiang University Science B",
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publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1800155"
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%T Dopamine receptor D2 polymorphism is associated with alleviation of obesity after 8-year follow-up: a retrospective cohort study in obese Chinese children and adolescents
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T1 - Dopamine receptor D2 polymorphism is associated with alleviation of obesity after 8-year follow-up: a retrospective cohort study in obese Chinese children and adolescents
A1 - Jian-fang Zhu
A1 - Lian-hui Chen
A1 - Ke Yuan
A1 - Li Liang
A1 - Chun-lin Wang
J0 - Journal of Zhejiang University Science B
VL - 19
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DOI - 10.1631/jzus.B1800155


Abstract: 
Objective: The aim of this study was to explore the association of dopamine receptor D2 (DRD2) polymorphism and alleviation of obesity in children and adolescents after 8-year follow-up. Methods: This retrospective cohort study included obese children and adolescents with a follow-up period of 8 years. Baseline clinical characteristics and DRD2 polymorphisms (including rs1076562, rs2075654, and rs4586205) were extracted from medical records. A follow-up visit was performed in May 2017 to collect related data including height, weight, diet compliance, and exercise compliance. Results: One hundred and nine obese children and adolescents were included in the current study. Among three DRD2 single nucleotide polymorphisms, only rs2075654 had a statistically significant association with alleviation of obesity, as the alleviation rate for minor allele carriers (68.6% for TC+TT) was higher compared to the major allele homozygote (43.3% for CC). After adjusting for all related factors, the hazard ratio of rs2075654 minor allele carriers for the alleviation of obesity was 3.34 (95% confidence interval (CI): 1.30‒8.58). Conclusions: The rs2075654 polymorphism of DRD2 is related to long-term obesity alleviation in obese Chinese children and adolescents.

中国肥胖儿童青少年多巴胺受体D2基因多态性与随访8年后体重变化的相关性研究

目的:在经过8年随访的中国肥胖儿童青少年中,评价多巴胺受体D2(DRD2)基因多态性和肥胖缓解的相关性.
创新点:探索肥胖儿童青少年的基因多态性与长期体重变化的相关性,期望能够指导肥胖儿童青少年的临床诊疗.
方法:该研究纳入了我院随访8年的108名肥胖儿童及青少年.基线的临床资料和DRD2基因多态性(包括rs1076562、rs2075654和rs4586205)相关数据从原始病历及检验结果中提取.于2017年5月份进行电话随访,采集相关数据,包括身高、体重、饮食和运动干预依从性.
结论:DRD2基因rs2075654位点多态性与肥胖儿童青 少年的长期体重变化有相关性.

关键词:肥胖;随访研究;多巴胺受体D2;儿童;青少年

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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