Full Text:   <1473>

Summary:  <1147>

CLC number: R656.2

On-line Access: 2018-01-11

Received: 2016-11-23

Revision Accepted: 2017-03-17

Crosschecked: 2017-12-18

Cited: 0

Clicked: 3023

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
Open peer comments

Journal of Zhejiang University SCIENCE B 2018 Vol.19 No.1 P.65-70

http://doi.org/10.1631/jzus.B1600383


Activity of metalloproteinases and adiponectin in obese patients—a possible factor of incisional hernias after bariatric procedures


Author(s):  Wojciech Szczęsny, Magdalena Kuligowska-Prusińska, Stanisław Dąbrowiecki, Jakub Szmytkowski, Adrian Reśliński, Maciej Słupski

Affiliation(s):  Ludwik Rydygier College of Medicine in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland

Corresponding email(s):   bigar@wp.pl

Key Words:  Metalloproteinase, Adiponectin, Obesity, Incisional hernia


Wojciech Szczęsny, Magdalena Kuligowska-Prusińska, Stanisław Dąbrowiecki, Jakub Szmytkowski, Adrian Reśliński, Maciej Słupski. Activity of metalloproteinases and adiponectin in obese patients—a possible factor of incisional hernias after bariatric procedures[J]. Journal of Zhejiang University Science B, 2018, 19(1): 65-70.

@article{title="Activity of metalloproteinases and adiponectin in obese patients—a possible factor of incisional hernias after bariatric procedures",
author="Wojciech Szczęsny, Magdalena Kuligowska-Prusińska, Stanisław Dąbrowiecki, Jakub Szmytkowski, Adrian Reśliński, Maciej Słupski",
journal="Journal of Zhejiang University Science B",
volume="19",
number="1",
pages="65-70",
year="2018",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1600383"
}

%0 Journal Article
%T Activity of metalloproteinases and adiponectin in obese patients—a possible factor of incisional hernias after bariatric procedures
%A Wojciech Szczęsny
%A Magdalena Kuligowska-Prusińska
%A Stanisław Dąbrowiecki
%A Jakub Szmytkowski
%A Adrian Reśliński
%A Maciej Słupski
%J Journal of Zhejiang University SCIENCE B
%V 19
%N 1
%P 65-70
%@ 1673-1581
%D 2018
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1600383

TY - JOUR
T1 - Activity of metalloproteinases and adiponectin in obese patients—a possible factor of incisional hernias after bariatric procedures
A1 - Wojciech Szczęsny
A1 - Magdalena Kuligowska-Prusińska
A1 - Stanisław Dąbrowiecki
A1 - Jakub Szmytkowski
A1 - Adrian Reśliński
A1 - Maciej Słupski
J0 - Journal of Zhejiang University Science B
VL - 19
IS - 1
SP - 65
EP - 70
%@ 1673-1581
Y1 - 2018
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1600383


Abstract: 
Purpose: metalloproteinases are a key component of the pathogenesis of abdominal hernias. obesity is considered a risk factor in herniogenesis and hernia recurrence. The aim of this study was to evaluate the serum concentrations of metalloproteinase-2 (MMP-2), MMP-9, MMP-13, and adiponectin in morbidly obese and non-overweight controls. Materials and methods: The participants were recruited from among patients undergoing bariatric and non-bariatric surgery and divided into two groups: I (body mass index (BMI)≥35 kg/m2, n=40) and II (BMI<25 kg/m2, n=30). Serum concentrations of MMP-2, MMP-9, MMP-13, and adiponectin were measured using enzyme-linked immunosorbent assay (ELISA). Results: A statistically significant difference between groups was observed for MMP-2 concentration. The median MMP-9 concentration was higher in the obese group, but the difference was not statistically significant. Median MMP-13 concentrations did not differ between groups. Serum adiponectin concentration was insignificantly higher in the non-obese group. Conclusions: The elevated serum MMP-2 and MMP-9 concentrations in obese individuals may be related to the higher incidence of incisional hernias in this population.

肥胖患者体内金属蛋白酶和脂联素的活性-- 肥胖手术后造成切口疝的可能因素

目的:主要研究病态肥胖患者与正常人血清中金属蛋白酶2(MMP-2)、MMP-9、MMP-13和脂联素的浓度.
创新点:建立血清中MMP-2、MMP-9、MMP-13和脂联素的浓度与肥胖和切口疝的关系.
方法:参与实验的人员为进行肥胖手术的患者和不进行肥胖手术的患者,并将他们分为两组:I(体重指数(BMI)≥35 kg/m2,n=40)和II(BMI<25 kg/m2,n=30),并使用酶联免疫吸附实验测定受试人员体内血清中MMP-2、MMP-9、MMP-13和脂联素的浓度.
结论:MMP-2的浓度在肥胖组中更高,且在两组血清中有显著性差异.虽然MMP-9的浓度在肥胖组中更高,但是两组之间没有显著性差异.MMP-13在两组间没有差异.血清中脂联素的浓度在非肥胖组更高,但无显著性差异.因此,血清中MMP-2和MMP-9的浓度在肥胖人群中与更高的切口疝发病率有关.

关键词:金属蛋白酶;脂联素;肥胖症;切口疝

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]Agren MS, Jorgensen LN, Andersen M, et al., 1998. Matrix metalloproteinase 9 level predicts optimal collagen deposition during early wound repair in humans. Br J Surg, 85(1):68-71.

[2]Andrade VL, Petruceli E, Belo VA, et al., 2012. Evaluation of plasmatic MMP-8, MMP-9, TIMP-1 and MPO levels in obese and lean women. Clin Biochem, 459(6):412-415.

[3]Antoniou SA, Antoniou GA, Granderath FA, et al., 2009. The role of matrix metalloproteinases in the pathogenesis of abdominal wall hernias. Eur J Clin Invest, 39(11):953-959.

[4]Aren A, Gökçe AH, Gökçe FS, et al., 2011. Roles of matrix metalloproteinases in the etiology of inguinal hernia. Hernia, 15(6):667-671.

[5]Bellón JM, Bajo A, Ga-Honduvilla N, et al., 2001. Fibroblasts from the transversalis fascia of young patients with direct inguinal hernias show constitutive MMP-2 overexpression. Ann Surg, 233(2):287-291.

[6]Bienertová-Vašků J, Novák J, Zlámal F, et al., 2014. The prediction role of indexes of circulating adipokines for common anthropometric and nutritional characteristics of obesity in the obese Central European population. Eat Behav, 15(2):244-251.

[7]Bouloumié A, Sengenès C, Portolan G, et al., 2001. Adipocyte produces matrix metalloproteinases 2 and 9: involvement in adipose differentiation. Diabetes, 50(9):2080-2086.

[8]Catalán V, Gómez-Ambrosi J, Ramirez B, et al., 2007. Proinflammatory cytokines in obesity: impact of type 2 diabetes mellitus and gastric bypass. Obes Surg, 17(11):1464-1474.

[9]Catalán V, Gómez-Ambrosi J, Rodríguez A, et al., 2009. Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans. J Mol Med, 87(8):803-813.

[10]Catalán V, Gómez-Ambrosi J, Rodríguez A, et al., 2016. Increased interleukin-32 levels in obesity promote adipose tissue inflammation and extracellular matrix remodeling: effect of weight loss. Diabetes, 65(12):3636-3648.

[11]Derosa G, Ferrari I, D'Angelo A, et al., 2008. Matrix metalloproteinase-2 and -9 levels in obese patients. Endothelium, 15(4):219-224.

[12]Frühbeck G, 2015. Bariatric and metabolic surgery: a shift in eligibility and success criteria. Nat Rev Endocrinol, 11(8):465-477.

[13]Giannakos E, Vardali E, Bartekova M, et al., 2016. Changes in activities of circulating MMP-2 and MMP-9 in patients suffering from heart failure in relation to gender, hypertension and treatment: a cross-sectional study. Physiol Res, 65(Suppl 1):S149-S152.

[14]Głowińska-Olszewska B, Urban M, 2007. Elevated matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in obese children and adolescents. Metabolism, 56(6):799-805.

[15]Gómez-Ambrosi J, Silva C, Galofré JC, et al., 2011. Body adiposity and type 2 diabetes: increased risk with a high body fat percentage even having a normal BMI. Obesity (Silver Spring), 19(7):1439-1444.

[16]Gumbau V, Bruna M, Canelles E, et al., 2014. A prospective study on inflammatory parameters in obese patients after sleeve gastrectomy. Obes Surg, 24(6):903-908.

[17]Gummesson A, Hagg D, Olson FJ, et al., 2009. Adipose tissue is not an important source for matrix metalloproteinase-9 in the circulation. Scand J Clin Lab Invest, 69(6):636-642.

[18]Henriksen N, 2016. Systemic and local collagen turnover in hernia patients. Dan Med J., 63(7):B5265.

[19]Henriksen NA, Sørensen LT, Jorgensen LN, et al., 2013. Circulating levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in patients with incisional hernia. Wound Repair Regen, 21(5):661-666.

[20]Jung UJ, Choi MS, 2014. Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. Int J Mol Sci, 15(4):6184-6223.

[21]Klinge U, Si ZY, Zheng H, et al., 2001. Collagen I/III and matrix metalloproteinases (MMP) 1 and 13 in the fascia of patients with incisional hernias. J Invest Surg, 14(1):47-54.

[22]Liu Y, Min D, Bolton T, et al., 2009. Increased matrix metalloproteinase-9 predicts poor wound healing in diabetic foot ulcers. Diabetes Care, 32(11):117-119.

[23]Mohebali K, Young DM, Hansen SL, et al., 2009. Open incisional hernia repair at an academic tertiary care medical center. Arch Surg, 144(9):848-852.

[24]Moreno-Navarrete JM, Catalán V, Whyte L, et al., 2012. The L-α-lysophosphatidylinositol/GPR55 system and its potential role in human obesity. Diabetes, 61(2):281-291.

[25]Pascual G, Rodríguez M, Gómez-Gil V, et al., 2010. Active matrix metalloproteinase-2 upregulation in the abdominal skin of patients with direct inguinal hernia. Eur J Clin Invest, 40(12):1113-1121.

[26]Rodríguez A, Catalán V, Gómez-Ambrosi J, et al., 2011. Aquaglyceroporins serve as metabolic gateways in adiposity and insulin resistance control. Cell Cycle, 15(10):1548-1556.

[27]Rosch R, Klinge U, Si Z, et al., 2002. A role for the collagen I/III and MMP-1/-13 genes in primary inguinal hernia? BMC Med Genet, 3(1):2.

[28]Salameh JR, Talbott LM, May W, et al., 2007. Role of biomarkers in incisional hernias. Am Surg, 73(6):561-568.

[29]Smigielski J, Kołomecki K, Ziemniak P, et al., 2009. Degradation of collagen by metalloproteinase 2 in patients with abdominal hernias. Eur Surg Res, 42(2):118-121.

[30]Smigielski J, Brocki M, Kuzdak K, et al., 2011. Serum MMP 2 and TIMP 2 in patients with inguinal hernias. Eur J Clin Invest, 41(6):584-588.

[31]Sørensen LT, 2006. Effect of lifestyle, gender and age on collagen formation and degradation. Hernia, 10(6):456-461.

[32]Stumpf M, Cao W, Klinge U, et al., 2002. Collagen distribution and expression of matrix metalloproteinases 1 and 13 in patients with anastomotic leakage after large-bowel surgery. Langenbecks Arch Surg, 386(7):502-506.

[33]Sugerman HJ, Kellum Jr JM, Reines HD, et al., 1996. Greater risk of incisional hernia with morbidly obese than steroid-dependent patients and low recurrence with prefascial polypropylene mesh. Am J Surg, 171(1):80-84.

[34]Tham JC, Howes N, le Roux CW, 2014. The role of bariatric surgery in the treatment of diabetes. Ther Adv Chronic Dis, 5(3):149-157.

[35]Trakhtenbroit MA, Leichman JG, Algahim MF, et al., 2009. Body weight, insulin resistance, and serum adipokine levels 2 years after 2 types of bariatric surgery. Am J Med, 122(5):435-442.

[36]Tsioufis C, Bafakis I, Kasiakogias A, et al., 2012. The role of matrix metalloproteinases in diabetes mellitus. Curr Top Med Chem, 12(10):1159-1165.

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2022 Journal of Zhejiang University-SCIENCE