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On-line Access: 2021-06-11

Received: 2020-09-12

Revision Accepted: 2020-12-21

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Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Huiyuan ZHU

https://orcid.org/0000-0002-0634-8687

Aiguo XU

https://orcid.org/0000-0003-1391-7734

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Journal of Zhejiang University SCIENCE B 2021 Vol.22 No.6 P.512-520

http://doi.org/10.1631/jzus.B2000555


Serum macrophage migration inhibitory factor as a potential biomarker to evaluate therapeutic response in patients with allergic asthma: an exploratory study


Author(s):  Huiyuan ZHU, Shaochun YAN, Jingshuo WU, Zhong ZHANG, Xiaolin LI, Zheng LIU, Xing MA, Lina ZHOU, Lin ZHANG, Mingming FENG, Yiwei GENG, Aixin ZHANG, Sabina JANCIAUSKIENE, Aiguo XU

Affiliation(s):  Department of Pulmonary and Critical Care Medicine, Zhengzhou Second People’s Hospital, Zhengzhou Affiliated Hospital of Jinan University, Zhengzhou 450006, China; more

Corresponding email(s):   aiguoxu@zzu.edu.cn

Key Words:  Macrophage migration inhibitory factor (MIF), Allergic asthma, Eosinophilic inflammation, Fractional exhaled nitric oxide, Immunoglobulin E (IgE)


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Huiyuan ZHU, Shaochun YAN, Jingshuo WU, Zhong ZHANG, Xiaolin LI, Zheng LIU, Xing MA, Lina ZHOU, Lin ZHANG, Mingming FENG, Yiwei GENG, Aixin ZHANG, Sabina JANCIAUSKIENE, Aiguo XU. Serum macrophage migration inhibitory factor as a potential biomarker to evaluate therapeutic response in patients with allergic asthma: an exploratory study[J]. Journal of Zhejiang University Science B, 2021, 22(6): 512-520.

@article{title="Serum macrophage migration inhibitory factor as a potential biomarker to evaluate therapeutic response in patients with allergic asthma: an exploratory study",
author="Huiyuan ZHU, Shaochun YAN, Jingshuo WU, Zhong ZHANG, Xiaolin LI, Zheng LIU, Xing MA, Lina ZHOU, Lin ZHANG, Mingming FENG, Yiwei GENG, Aixin ZHANG, Sabina JANCIAUSKIENE, Aiguo XU",
journal="Journal of Zhejiang University Science B",
volume="22",
number="6",
pages="512-520",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2000555"
}

%0 Journal Article
%T Serum macrophage migration inhibitory factor as a potential biomarker to evaluate therapeutic response in patients with allergic asthma: an exploratory study
%A Huiyuan ZHU
%A Shaochun YAN
%A Jingshuo WU
%A Zhong ZHANG
%A Xiaolin LI
%A Zheng LIU
%A Xing MA
%A Lina ZHOU
%A Lin ZHANG
%A Mingming FENG
%A Yiwei GENG
%A Aixin ZHANG
%A Sabina JANCIAUSKIENE
%A Aiguo XU
%J Journal of Zhejiang University SCIENCE B
%V 22
%N 6
%P 512-520
%@ 1673-1581
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2000555

TY - JOUR
T1 - Serum macrophage migration inhibitory factor as a potential biomarker to evaluate therapeutic response in patients with allergic asthma: an exploratory study
A1 - Huiyuan ZHU
A1 - Shaochun YAN
A1 - Jingshuo WU
A1 - Zhong ZHANG
A1 - Xiaolin LI
A1 - Zheng LIU
A1 - Xing MA
A1 - Lina ZHOU
A1 - Lin ZHANG
A1 - Mingming FENG
A1 - Yiwei GENG
A1 - Aixin ZHANG
A1 - Sabina JANCIAUSKIENE
A1 - Aiguo XU
J0 - Journal of Zhejiang University Science B
VL - 22
IS - 6
SP - 512
EP - 520
%@ 1673-1581
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2000555


Abstract: 
BackgroundPrevious studies have shown that macrophage migration inhibitory factor (MIF) is involved in the pathogenesis of asthma. This study aimed to investigate whether serum MIF reflects a therapeutic response in allergic asthma.
MethodsWe enrolled 30 asthmatic patients with mild-to-moderate exacerbations and 20 healthy controls, analyzing the parameter levels of serum MIF, serum total immunoglobulin E (tIgE), peripheral blood eosinophil percentage (EOS%), and fractional exhaled nitric oxide (FeNO). Lung function indices were used to identify disease severity and therapeutic response.
ResultsOur study showed that all measured parameters in patients were at higher levels than those of controls. After one week of treatment, most parameter levels decreased significantly except for serum tIgE. Furthermore, we found that serum MIF positively correlated with EOS% as well as FeNO, but negatively correlated with lung function indices. Receiver operator characteristic (ROC) curve analysis indicated that among the parameters, serum MIF exhibited a higher capacity to evaluate therapeutic response. The area under the curve (AUC) of MIF was 0.931, with a sensitivity of 0.967 and a specificity of 0.800.
ConclusionsOur results suggested that serum MIF may serve as a potential biomarker for evaluating therapeutic response in allergic asthma with mild-to-moderate exacerbations.

血清巨噬细胞移动抑制因子作为评估过敏性哮喘患者治疗反应的潜在标志物:一项探索性研究

目的:探讨血清巨噬细胞移动抑制因子在过敏性哮喘治疗反应评估中的应用价值。
创新点:采用血清巨噬细胞移动抑制因子评估过敏性哮喘的治疗反应。
方法:我们纳入了过敏性哮喘轻中度急性发作患者30例,并以20例健康人为对照,分别检测和分析了治疗前后患者以及健康人的血清巨噬细胞移动抑制因子、总免疫球蛋白E(总IgE)、外周血嗜酸性粒细胞百分数和呼出气一氧化氮等指标,同时进行肺功能检查以监测患者的治疗反应。
结论:血清巨噬细胞移动抑制因子作为一种潜在的生物标志物,可用于评估过敏性哮喘轻中度急性发作患者的治疗反应。

关键词:巨噬细胞移动抑制因子;过敏性哮喘;嗜酸性粒细胞炎症;呼出气一氧化氮;免疫球蛋白E(IgE)

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