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CLC number: R711.74

On-line Access: 2017-03-08

Received: 2016-10-17

Revision Accepted: 2016-12-19

Crosschecked: 2017-02-13

Cited: 2

Clicked: 3508

Citations:  Bibtex RefMan EndNote GB/T7714


Jing Ye


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Journal of Zhejiang University SCIENCE B 2017 Vol.18 No.3 P.249-255


Prognostic value of human papillomavirus 16/18 genotyping in low-grade cervical lesions preceded by mildly abnormal cytology

Author(s):  Jing Ye, Bei Cheng, Yi-fan Cheng, Ye-li Yao, Xing Xie, Wei-guo Lu, Xiao-dong Cheng

Affiliation(s):  Department of Gynecologic Oncology, Womens Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China

Corresponding email(s):   attwentyone@163.com, chengxd@zju.edu.cn

Key Words:  Low-grade squamous intraepithelial lesion (LSIL), Cervical intraepithelial neoplasia grade 1 (CIN1), Human papillomavirus (HPV), HPV16/18 genotyping, Prognostic value, Prospective study

Jing Ye, Bei Cheng, Yi-fan Cheng, Ye-li Yao, Xing Xie, Wei-guo Lu, Xiao-dong Cheng. Prognostic value of human papillomavirus 16/18 genotyping in low-grade cervical lesions preceded by mildly abnormal cytology[J]. Journal of Zhejiang University Science B, 2017, 18(3): 249-255.

@article{title="Prognostic value of human papillomavirus 16/18 genotyping in low-grade cervical lesions preceded by mildly abnormal cytology",
author="Jing Ye, Bei Cheng, Yi-fan Cheng, Ye-li Yao, Xing Xie, Wei-guo Lu, Xiao-dong Cheng",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Prognostic value of human papillomavirus 16/18 genotyping in low-grade cervical lesions preceded by mildly abnormal cytology
%A Jing Ye
%A Bei Cheng
%A Yi-fan Cheng
%A Ye-li Yao
%A Xing Xie
%A Wei-guo Lu
%A Xiao-dong Cheng
%J Journal of Zhejiang University SCIENCE B
%V 18
%N 3
%P 249-255
%@ 1673-1581
%D 2017
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1600473

T1 - Prognostic value of human papillomavirus 16/18 genotyping in low-grade cervical lesions preceded by mildly abnormal cytology
A1 - Jing Ye
A1 - Bei Cheng
A1 - Yi-fan Cheng
A1 - Ye-li Yao
A1 - Xing Xie
A1 - Wei-guo Lu
A1 - Xiao-dong Cheng
J0 - Journal of Zhejiang University Science B
VL - 18
IS - 3
SP - 249
EP - 255
%@ 1673-1581
Y1 - 2017
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1600473

Histological low-grade squamous intraepithelial lesion/cervical intraepithelial neoplasia grade 1 (LSIL/CIN1) preceded by normal or mildly abnormal cytology is recommended for conservative follow-up, with no separated management. In this study, we assessed the triage value of human papillomavirus (HPV) 16/18 genotyping in 273 patients with LSIL/CIN1. HPV16/18 genotyping was performed at baseline and follow-up was at 6-monthly intervals for up to 2 years. At each follow-up, women positive for cytology or high-risk HPV (hrHPV) were referred for colposcopy. Enrollment cytology, HPV16/18 genotyping, and questionnaire-obtained factors were linked to the 2-year cumulative progression rate. Univariate and multivariate analyses were performed taking into account time-to-event with Cox proportional hazard regression. The results showed that 190 cases (69.6%) regressed, 37 (13.6%) persisted, and 46 (16.8%) progressed. HPV16/18 positivity (hazard ratio (HR), 2.708; 95% confidence interval (CI), 1.432–5.121; P=0.002) is significantly associated with higher 2-year cumulative progression rate. Sub-analysis by enrollment cytology and age restricted the positive association among patients preceded by mildly abnormal cytology and aged 30 years or older. Immediate treatment is a rational recommendation for the high-risk subgroup, when good compliance is not assured.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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