Full Text:   <1513>

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CLC number: R541.4

On-line Access: 2017-08-08

Received: 2017-02-11

Revision Accepted: 2017-05-01

Crosschecked: 2017-07-19

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Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Dong-Yi Jin

http://orcid.org/0000-0001-6922-5484

Guo-Ping Shi

http://orcid.org/0000-0001-5809-2567

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Journal of Zhejiang University SCIENCE B 2017 Vol.18 No.8 P.685-695

http://doi.org/10.1631/jzus.B1700073


Interleukin-18, matrix metalloproteinase-22 and -29 are independent risk factors of human coronary heart disease


Author(s):  Dong-Yi Jin, Cong-Lin Liu, Jun-Nan Tang, Zhao-Zhong Zhu, Xue-Xi Xuan, Xiao-Dan Zhu, Yun-Zhe Wang, Tian-Xia Zhang, De-Liang Shen, Xiao-Fang Wang, Guo-Ping Shi, Jin-Ying Zhang

Affiliation(s):  Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; more

Corresponding email(s):   gshi@bwh.harvard.edu, jyzhang@zzu.edu.cn

Key Words:  Interleukin-18, Matrix metalloproteinase (MMP)-22, MMP-29, Coronary heart disease, Risk factor


Dong-Yi Jin, Cong-Lin Liu, Jun-Nan Tang, Zhao-Zhong Zhu, Xue-Xi Xuan, Xiao-Dan Zhu, Yun-Zhe Wang, Tian-Xia Zhang, De-Liang Shen, Xiao-Fang Wang, Guo-Ping Shi, Jin-Ying Zhang. Interleukin-18, matrix metalloproteinase-22 and -29 are independent risk factors of human coronary heart disease[J]. Journal of Zhejiang University Science B, 2017, 18(8): 685-695.

@article{title="Interleukin-18, matrix metalloproteinase-22 and -29 are independent risk factors of human coronary heart disease",
author="Dong-Yi Jin, Cong-Lin Liu, Jun-Nan Tang, Zhao-Zhong Zhu, Xue-Xi Xuan, Xiao-Dan Zhu, Yun-Zhe Wang, Tian-Xia Zhang, De-Liang Shen, Xiao-Fang Wang, Guo-Ping Shi, Jin-Ying Zhang",
journal="Journal of Zhejiang University Science B",
volume="18",
number="8",
pages="685-695",
year="2017",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1700073"
}

%0 Journal Article
%T Interleukin-18, matrix metalloproteinase-22 and -29 are independent risk factors of human coronary heart disease
%A Dong-Yi Jin
%A Cong-Lin Liu
%A Jun-Nan Tang
%A Zhao-Zhong Zhu
%A Xue-Xi Xuan
%A Xiao-Dan Zhu
%A Yun-Zhe Wang
%A Tian-Xia Zhang
%A De-Liang Shen
%A Xiao-Fang Wang
%A Guo-Ping Shi
%A Jin-Ying Zhang
%J Journal of Zhejiang University SCIENCE B
%V 18
%N 8
%P 685-695
%@ 1673-1581
%D 2017
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1700073

TY - JOUR
T1 - Interleukin-18, matrix metalloproteinase-22 and -29 are independent risk factors of human coronary heart disease
A1 - Dong-Yi Jin
A1 - Cong-Lin Liu
A1 - Jun-Nan Tang
A1 - Zhao-Zhong Zhu
A1 - Xue-Xi Xuan
A1 - Xiao-Dan Zhu
A1 - Yun-Zhe Wang
A1 - Tian-Xia Zhang
A1 - De-Liang Shen
A1 - Xiao-Fang Wang
A1 - Guo-Ping Shi
A1 - Jin-Ying Zhang
J0 - Journal of Zhejiang University Science B
VL - 18
IS - 8
SP - 685
EP - 695
%@ 1673-1581
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PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1700073


Abstract: 
Background: coronary heart disease (CHD) is characterized by arterial wall inflammation and matrix degradation. matrix metalloproteinase (MMP)-22 and -29 and pro-inflammatory cytokine interleukin-18 (IL18) are present in human hearts. IL18 may regulate MMP-22 and -29 expression, which may correlate with CHD progression. Methods and results: Immunoblot analysis showed that IL18 induced MMP-22 expression in human aortic smooth muscle cells. The Mann Whitney test from a prospective study of 194 CHD patients and 68 non-CHD controls demonstrated higher plasma levels of IL18, MMP-22 and -29 in CHD patients than in the controls. A logistic regression test suggested that plasma IL18 (odds ratio (OR)=1.131, P=0.007), MMP-22 (OR=1.213, P=0.040), and MMP-29 (OR=1.198, P=0.033) were independent risk factors of CHD. Pearson’s correlation test showed that IL18 (coefficient (r)=0.214, P=0.045; r=0.246, P=0.031) and MMP-22 (r=0.273, P=0.006; r=0.286, P=0.012) were associated with the Gensini score before and after adjusting for potential confounding factors. The multivariate Pearson’s correlation test showed that plasma MMP-22 levels correlated positively with high-sensitive-C-reactive protein (hs-CRP) (r=0.167, P=0.023), and MMP-29 levels correlated negatively with triglyceride (r=−0.169, P=0.018). Spearman’s correlation test indicated that plasma IL18 levels associated positively with plasma MMP-22 (r=0.845, P<0.001) and MMP-29 (r=0.548, P<0.001). Conclusions: Our observations suggest that IL18, MMP-22 and -29 serve as biomarkers and independent risk factors of CHD. Increased systemic IL18 in CHD patients may contribute to elevated plasma MMP-22 and -29 levels in these patients.

白细胞介素18、基质金属蛋白酶-22及-29与冠心病发生风险的关联研究

目的:探讨冠心病患者血浆白细胞介素18(IL18)水平是否与基质金属蛋白酶-22和-29(MMP-22和MMP-29)的表达水平相关,以及此类患者血浆中MMP-22及MMP-29水平是否升高。
创新点:首次证实在动脉粥样硬化过程中炎症反应可能促进MMP-22及MMP-29的表达,IL18是冠心病患者中调控MMP表达的炎症因子之一。
方法:通过免疫印迹分析检测IL18对人体动脉平滑肌细胞MMP-22的表达;通过Mann Whitney检验对来自于194例冠心病患者和68例对照组的前瞻性研究进行分析;通过logistic回归分析冠心病的独立风险因素;通过Pearson相关性分析IL18和MMP-22的表达水平与冠状动脉Gensini积分的相关性;通过多变量Pearson相关性分析血浆MMP-22水平与超敏C反应蛋白(hs-CRP)及甘油三酯水平的相关性;通过Spearman相关性分析血浆IL18水平与MMP-22和MMP-29的相关性。
结论:冠心病患者血浆IL18水平升高可能导致此类患者血浆MMP-22和MMP-29水平升高。IL18、MMP-22和MMP-29可能是冠心病的生物标记物和独立风险因素。

关键词:白细胞介素18;基质金属蛋白酶-22;基质金属蛋白酶-29;冠心病;风险因素

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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