Full Text:   <1435>

Summary:  <1364>

CLC number: R711.74

On-line Access: 2017-11-06

Received: 2016-11-26

Revision Accepted: 2017-06-02

Crosschecked: 2017-10-20

Cited: 0

Clicked: 3258

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Lei Yan

http://orcid.org/0000-0003-2156-1483

-   Go to

Article info.
Open peer comments

Journal of Zhejiang University SCIENCE B 2017 Vol.18 No.11 P.1022-1025

http://doi.org/10.1631/jzus.B1600523


Fertility outcomes in infertile women with complex hyperplasia or complex atypical hyperplasia who received progestin therapy and in vitro fertilization


Author(s):  Miao Li, Jia-lun Song, Ying Zhao, She-ling Wu, Hong-bin Liu, Rong Tang, Lei Yan

Affiliation(s):  Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250012, China; more

Corresponding email(s):   yanleiandu@163.com

Key Words:  Progestin therapy, Endometrial hyperplasia, In vitro fertilization


Miao Li, Jia-lun Song, Ying Zhao, She-ling Wu, Hong-bin Liu, Rong Tang, Lei Yan. Fertility outcomes in infertile women with complex hyperplasia or complex atypical hyperplasia who received progestin therapy and in vitro fertilization[J]. Journal of Zhejiang University Science B, 2017, 18(11): 1022-1025.

@article{title="Fertility outcomes in infertile women with complex hyperplasia or complex atypical hyperplasia who received progestin therapy and in vitro fertilization",
author="Miao Li, Jia-lun Song, Ying Zhao, She-ling Wu, Hong-bin Liu, Rong Tang, Lei Yan",
journal="Journal of Zhejiang University Science B",
volume="18",
number="11",
pages="1022-1025",
year="2017",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1600523"
}

%0 Journal Article
%T Fertility outcomes in infertile women with complex hyperplasia or complex atypical hyperplasia who received progestin therapy and in vitro fertilization
%A Miao Li
%A Jia-lun Song
%A Ying Zhao
%A She-ling Wu
%A Hong-bin Liu
%A Rong Tang
%A Lei Yan
%J Journal of Zhejiang University SCIENCE B
%V 18
%N 11
%P 1022-1025
%@ 1673-1581
%D 2017
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1600523

TY - JOUR
T1 - Fertility outcomes in infertile women with complex hyperplasia or complex atypical hyperplasia who received progestin therapy and in vitro fertilization
A1 - Miao Li
A1 - Jia-lun Song
A1 - Ying Zhao
A1 - She-ling Wu
A1 - Hong-bin Liu
A1 - Rong Tang
A1 - Lei Yan
J0 - Journal of Zhejiang University Science B
VL - 18
IS - 11
SP - 1022
EP - 1025
%@ 1673-1581
Y1 - 2017
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1600523


Abstract: 
This study aimed to evaluate fertility and oncologic outcomes in women with complex hyperplasia (CH) or complex atypical hyperplasia (CAH) who received fertility-sparing therapy and in vitro fertilization (IVF). Endometrial carcinoma is the most common carcinoma of the female genital tract, and is associated with endometrial hyperplasia (EH) resulting from long-term unopposed estrogenic stimulation of the endometrium. EH is characterized by non-physiological proliferation of endometrium that results in glands with irregular shapes and varying sizes. The World Health Organization (WHO) classified it into four types: simple or complex hyperplasia with or without atypia. CH is characterized by glands with irregular outlines that demonstrate marked structural complexity and back-to-back crowding. Atypical hyperplasia designates a proliferation of glands exhibiting cytologic atypia, in which varying degrees of nuclear atypia and loss of polarity are present. It has been reported that high-dose progestin is safe and efficient for CAH or early-stage low-grade carcinoma for young women who desire fertility-preserving treatment. However, few studies have reported the differences of pregnancy outcomes between patients with CAH and CH, while those patients take a great proportion in people suffered from infertility. More studies about the outcome of IVF are needed. Our aim is to evaluate fertility and oncological outcomes in women with CH or CAH who received fertility-sparing therapy.

子宫内膜不典型增生或复杂性增生不孕患者孕激素和IVF后的妊娠结局分析

概要:本回顾性队列研究包括了年龄在45岁以下被诊断为伴有或不伴有不典型增生的子宫内膜复杂性增生患者,对孕激素治疗后的临床结局及妊娠结局进行了比较。结果表明,伴有或不伴有不典型增生的子宫内膜复杂性增生接受孕激素治疗后,其临床及妊娠结局并没有显著差异。我们认为对于这些患者,在短暂的孕激素治疗控制病情后,尽快施行体外受精-胚胎移植治疗(IVF)将有利于改善其妊娠结局。
关键词:孕激素治疗;子宫内膜增生;体外受精-胚胎移植治疗(IVF)

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]Chen, M., Jin, Y., Li, Y., et al., 2016. Oncologic and reproductive outcomes after fertility-sparing management with oral progestin for women with complex endometrial hyperplasia and endometrial cancer. Int. J. Gynaecol. Obstet., 132(1):34-38.

[2]Gadducci, A., Spirito, N., Baroni, E., et al., 2009. The fertility-sparing treatment in patients with endometrial atypical hyperplasia and early endometrial cancer: a debated therapeutic option. Gynecol. Endocrinol., 25(10):683-691.

[3]Gallos, I.D., Ganesan, R., Gupta, J.K., 2013. Prediction of regression and relapse of endometrial hyperplasia with conservative therapy. Obstet. Gynecol., 121(6):1165-1171.

[4]Horn, L.C., Meinel, A., Handzel, R., et al., 2007. Histopathology of endometrial hyperplasia and endometrial carcinoma: an update. Ann. Diagn Pathol., 11(4):297-311.

[5]Inoue, O., Hamatani, T., Susumu, N., et al., 2016. Factors affecting pregnancy outcomes in young women treated with fertility-preserving therapy for well-differentiated endometrial cancer or atypical endometrial hyperplasia. Reprod. Biol. Endocrinol., 14:2.

[6]Kurman, R.J., Kaminski, P.F., Norris, H.J., 1985. The behavior of endometrial hyperplasia: a long-term study of “untreated” hyperplasia in 170 patients. Cancer, 56(2):403-412.

[7]Li, C., Bai, Y., Yan, L., et al., 2016. SPAG9 may be a potential prognostic markerof endometrial hyperplasia and grade 1 endometrioid adenocarcinoma treated with progestin. Gynecol. Obstet. Invest., 81(3):267-274.

[8]Orbo, A., Vereide, A., Arnes, M., et al., 2014. Levonorgestrel-impregnated intrauterine device as treatment for endometrial hyperplasia: a national multicenter randomised trial. BJOG, 121(4):477-486.

[9]Randall, T.C., Kurman, R.J., 1997. Progestin treatment of atypical hyperplasia and well-differentiated carcinoma of the endometrium in women under age 40. Obstet. Gynecol., 90(3):434-440.

[10]Siristatidis, C., Sergentanis, T.N., Kanavidis, P., et al., 2013. Controlled ovarian hyperstimulation for IVF: impact on ovarian, endometrial and cervical cancer—a systematic review and meta-analysis. Hum. Reprod. Update, 19(2):105-123.

[11]Stubert, J., Gerber, B., 2016. Current issues in the diagnosis and treatment of endometrial carcinoma. Geburtsh. Frauenheilk., 76(2):170-175.

[12]Yang, Y.F., Liao, Y.Y., Liu, X.L., et al., 2015. Prognosticfactors of regression and relapse of complex atypical hyperplasia and well-differentiated endometrioid carcinoma with conservative treatment. Gynecol. Oncol., 139(3):419-423.

[13]Zhou, R., Yang, Y., Lu, Q., et al., 2015. Prognostic factors of oncological and reproductive outcomes in fertility-sparing treatment of complex atypical hyperplasia and low-grade endometrial cancer using oral progestin in Chinese patients. Gynecol. Oncol., 139(3):424-428.

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2022 Journal of Zhejiang University-SCIENCE