Full Text:   <1294>

Summary:  <1151>

CLC number: R595.9

On-line Access: 2018-02-06

Received: 2017-11-15

Revision Accepted: 2018-01-25

Crosschecked: 2018-01-08

Cited: 0

Clicked: 2234

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Yuan-qiang Lu

https://orcid.org/0000-0002-9057-4344

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Journal of Zhejiang University SCIENCE B 2018 Vol.19 No.2 P.168-170

http://doi.org/10.1631/jzus.B1700567


HIV and paraquat poisoning: fighting fire with fire?


Author(s):  Yuan-qiang Lu

Affiliation(s):  Department of Emergency Medicine, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China

Corresponding email(s):   luyuanqiang@zju.edu.cn

Key Words:  Paraquat, Human immunodeficiency virus, Immunosuppressive therapy


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Yuan-qiang Lu. HIV and paraquat poisoning: fighting fire with fire?[J]. Journal of Zhejiang University Science B, 2018, 19(2): 168-170.

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publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1700567"
}

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%DOI 10.1631/jzus.B1700567

TY - JOUR
T1 - HIV and paraquat poisoning: fighting fire with fire?
A1 - Yuan-qiang Lu
J0 - Journal of Zhejiang University Science B
VL - 19
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Y1 - 2018
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1700567


Abstract: 
Though the cases of HIV patients with paraquat (PQ) poisoning are rare, we still found the common features. These recovered HIV patients tended to result in much less lung injury, and had low CD4+ T lymphocyte levels due to HIV infection, which meant they were under the immunosuppressive condition during treatment. This may be conducive to relieve the acute inflammation and lung fibrosis induced by PQ. Thus, we consider the immunosuppressive therapy for PQ poisoning to be appropriate. However, the drugs used currently may be not optimal for toxic patient. As next step, we will add the CD4+ T lymphocyte-targeted immunosuppressive drug to treat PQ poisoning patients.

HIV和百草枯中毒:以毒攻毒?

概要:回顾性分析PubMed收录的仅有3例合并有HIV的急性百草枯中毒患者的救治经过及预后.探索急性百草枯中毒新的免疫治疗.提出采用CD4+ T淋巴细胞作为急性百草枯中毒的免疫治疗精准靶点,可能改善预后,但需要进一步研究和临床实践.
关键词:百草枯;艾滋病病毒;免疫抑制治疗

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

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