Full Text:   <2326>

Summary:  <1995>

Suppl. Mater.: 

CLC number: R722.1

On-line Access: 2024-08-27

Received: 2023-10-17

Revision Accepted: 2024-05-08

Crosschecked: 2018-11-21

Cited: 0

Clicked: 4082

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Zhen Wang

https://orcid.org/0000-0002-7307-7485

-   Go to

Article info.
Open peer comments

Journal of Zhejiang University SCIENCE B 2018 Vol.19 No.12 P.973-978

http://doi.org/10.1631/jzus.B1800165


Risk factors and drug resistance in early-onset neonatal group B streptococcal disease


Author(s):  Ying-wei Wang, Yao-qiang Du, Xiao-lin Miao, Guang-yong Ye, Yi-yun Wang, Ai-bo Xu, Yun-zhong Jing, Yu Tong, Kai Xu, Mei-qin Zheng, Dong Chen, Zhen Wang

Affiliation(s):  Department of Laboratory Medicine, Tiantai Peoples Hospital, Taizhou 317200, China; more

Corresponding email(s):   chendong_wz@126.com, wangzhen@hmc.edu.cn

Key Words:  Neonate, Group B streptococcus, Risk factor, Drug-resistance


Share this article to: More <<< Previous Article|

Ying-wei Wang, Yao-qiang Du, Xiao-lin Miao, Guang-yong Ye, Yi-yun Wang, Ai-bo Xu, Yun-zhong Jing, Yu Tong, Kai Xu, Mei-qin Zheng, Dong Chen, Zhen Wang. Risk factors and drug resistance in early-onset neonatal group B streptococcal disease[J]. Journal of Zhejiang University Science B, 2018, 19(12): 973-978.

@article{title="Risk factors and drug resistance in early-onset neonatal group B streptococcal disease",
author="Ying-wei Wang, Yao-qiang Du, Xiao-lin Miao, Guang-yong Ye, Yi-yun Wang, Ai-bo Xu, Yun-zhong Jing, Yu Tong, Kai Xu, Mei-qin Zheng, Dong Chen, Zhen Wang",
journal="Journal of Zhejiang University Science B",
volume="19",
number="12",
pages="973-978",
year="2018",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1800165"
}

%0 Journal Article
%T Risk factors and drug resistance in early-onset neonatal group B streptococcal disease
%A Ying-wei Wang
%A Yao-qiang Du
%A Xiao-lin Miao
%A Guang-yong Ye
%A Yi-yun Wang
%A Ai-bo Xu
%A Yun-zhong Jing
%A Yu Tong
%A Kai Xu
%A Mei-qin Zheng
%A Dong Chen
%A Zhen Wang
%J Journal of Zhejiang University SCIENCE B
%V 19
%N 12
%P 973-978
%@ 1673-1581
%D 2018
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1800165

TY - JOUR
T1 - Risk factors and drug resistance in early-onset neonatal group B streptococcal disease
A1 - Ying-wei Wang
A1 - Yao-qiang Du
A1 - Xiao-lin Miao
A1 - Guang-yong Ye
A1 - Yi-yun Wang
A1 - Ai-bo Xu
A1 - Yun-zhong Jing
A1 - Yu Tong
A1 - Kai Xu
A1 - Mei-qin Zheng
A1 - Dong Chen
A1 - Zhen Wang
J0 - Journal of Zhejiang University Science B
VL - 19
IS - 12
SP - 973
EP - 978
%@ 1673-1581
Y1 - 2018
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1800165


Abstract: 
In recent years, group B streptococcus (GBS) has become an important pathogen that causes infections in many neonatal organs, including the brain, lung, and eye (Ballard et al., 2016). A series of studies performed on GBS infections in western countries have revealed that GBS is one of the primary pathogens implicated in perinatal infection, and GBS infections are a major cause of neonatal morbidity and mortality in the United States (Decheva et al., 2013). In China, GBS is mainly found by screens for adult urogenital tract and perinatal infections, and neonatal GBS infections have been rarely reported. The incidence rate of early-onset neonatal GBS disease is thought to be lower in China than in western countries; however, this data is controversial since it also reflects the clinical interest in GBS (Dabrowska-Szponar and Galinski, 2001).

新生儿早发型无乳链球菌感染的风险因素及耐药分析

目的:新生儿早发型无乳链球菌(GBS)是一种可致婴儿脑、肺和眼部发生感染甚至死亡的细菌.筛查其感染风险因素并建立概率预测模型有助于疾病的预防和控制,进一步分析GBS菌株的耐药类型和耐药基因,为疾病的临床诊断和治疗提供指导意见.
创新点:首次归类了新生儿感染GBS的众多因素,按照孕妇、分娩过程、胎儿因素分为三类,统计筛选出重要风险因素并建立Logistic回归的概率预测模型,并通过聚合酶链式反应(PCR)筛查到了相关耐药基因.
方法:收集2007年1月至2015年12月,浙江大学医学院附属妇产科医院、温州医科大学附属眼视光医院和温州市人民医院的实验组135例早发型GBS感染和对照组234例无感染的新生儿及其母亲的临床资料和标本,进行数据统计分析并构建概率预测模型,采用传统的药敏实验对所有GBS阳性标本进行耐药分析,同时PCR筛查耐药基因并测定序列.
结论:这9年间新生儿早发型GBS感染率呈上升趋势.孕妇泌尿系统感染、胎膜早破、胎龄这三项因素与感染GBS的结局存在显著关联,由此得出的Logistic回归模型可用于预测感染GBS的概率.135株GBS对克林霉素、红霉素、四环素的耐药菌株比例分别为51.11%、80.00%、91.11%,同时未发现对万古霉素、青霉素、呋喃妥因、力奈唑胺的耐药性.PCR筛查发现aac6ant6-Iaph3-IIITEM四个耐药基因,其中aph3-III仅存在于耐药株中,而测序发现aac6基因在非耐药株中相比耐药株存在一个缺失突变.临床上尽早对患者分离的GBS药敏试验,有助于合理用药和有效治疗.

关键词:新生儿;无乳链球菌;风险因素;耐药性

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]Ballard MS, Schønheyder HC, Knudsen JD, et al., 2016. The changing epidemiology of group B streptococcus bloodstream infection: a multi-national population-based assessment. Infect Dis (Lond), 48(5):386-391.

[2]Barbadoro P, Marigliano A, Savini S, et al., 2011. Group B Streptococcal sepsis: an old or ongoing threat? Am J Infect Control, 39(8):e45-e48.

[3]Crago MS, Gauer R, Frazier J, 2012. Clinical inquiry: does cervical membrane stripping in women with group B Streptococcus put the fetus at risk? J Fam Pract, 61(1):60a-60b.

[4]Dabrowska-Szponar M, Galinski J, 2001. Drug resistance of group B streptococci. Pol Merkur Lekarski, 10(60):442-444.

[5]Decheva A, Zlatkov V, Pandev K, et al., 2013. Screning study on pregnant women and neonatal infection with streptococcus agalactiae (group B streptococci). Akush Ginekol (Sofiia), 52(7):4-7.

[6]Fischer A, Liljander A, Kaspar H, et al., 2013. Camel Streptococcus agalactiae populations are associated with specific disease complexes and acquired the tetracycline resistance gene tetM via a Tn916-like element. Vet Res, 44:86.

[7]Hao K, Chen BY, Li KQ, et al., 2017. Cytotoxicity of anti-tumor herbal Marsdeniae tenacissimae extract on erythrocytes. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 18(7):597-604.

[8]Harimaya A, Yamazaki S, Himi T, et al., 2007. High prevalence of erythromycin resistance and macrolide-resistance genes, mefA and ermB, in Streptococcus pneumoniae isolates from the upper respiratory tracts of children in the Sapporo district, Japan. J Infect Chemother, 13(4):219-223.

[9]Juncosa-Morros T, Guardià-Llobet C, Bosch-Mestres J, et al., 2014. Streptococcus agalactiae late-onset neonatal infections in Barcelona (1996‒2010). Enferm Infecc Microbiol Clin, 32(9):574-578.

[10]Li JP, Zhou HJ, Yuan L, et al., 2009. Prevalence, genetic diversity, and antimicrobial susceptibility profiles of Staphylococcus aureus isolated from bovine mastitis in Zhejiang Province, China. J Zhejiang Univ-Sci B, 10(10):753-760.

[11]Persson E, Berg S, Bergseng H, et al., 2008. Antimicrobial susceptibility of invasive group B streptococcal isolates from south-west Sweden 1988-2001. Scand J Infect Dis, 40(4):308-313.

[12]Pimenta AC, Fernandes R, Moreira IS, 2014. Evolution of drug resistance: insight on TEM β-lactamases structure and activity and β-lactam antibiotics. Mini Rev Med Chem, 14(2):111-122.

[13]Schrag SJ, Zywicki S, Farley MM, et al., 2000. Group B streptococcal disease in the era of intrapartum antibiotic prophylaxis. N Engl J Med, 342(1):15-20.

[14]Yang DK, Liang HJ, Gao HL, et al., 2015. Analysis of drug-resistant gene detection of blaOXA-like genes from Acinetobacter baumannii. Genet Mol Res, 14(4):18999-19004.

[15]Yu SC, Wu HY, Wang W, et al., 2016. High-pressure balloon dilation for male anterior urethral stricture: single-center experience. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 17(9):722-727.

[16]Zhang Y, Wang Z, Jin T, et al., 2017. Hyperechoic demarcation line between a tumor and the muscularis propria layer as a marker for deciding the endoscopic treatment of gastric submucosal tumor. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 18(8):707-716.

[17]List of electronic supplementary materials

[18]Table S1 PCR primers in this study

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2024 Journal of Zhejiang University-SCIENCE